Development of new therapeutic strategy for skin cancers targeting CD147/Basigin
| Project/Area Number |
21591438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KANEKURA Takuro 鹿児島大学, 医歯学総合研究科, 教授 (70177509)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CD147/Basigin / 皮膚癌 / 治療 / 皮膚腫瘍学 / CD147/basigin / CD147 / Rasigin |
|---|
| Research Abstract |
We revealed that CD147/basigin promotes proliferation, invasion, and metastasis of malignant melanoma through regulating tumor cell glycolysis and regulates tumor cell adhesion to matrix through phosphorylating the focal adhesion kinase(FAK), a downstream kinase of integrin that co-localizes with CD147 on the cell surface. These findings demonstrate that CD147/basigin could be a target molecule for new therapeutic strategy for skin cancers.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Demethylation of TNFSF7 contributes to CD70 overexpression in CD4^+T cells from patients with systemic sclerosis2012
Author(s)
Jiang H, Xiao R, Lian X, Kanekura T, Luo Y, Yin Y, Zhang G, Ynag Y, Wang Y, Zhao M, Lu Q.
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Journal Title
Clin Immunol
Volume: 143
Pages: 39-44
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Peer Reviewed
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[Journal Article] Depletion of CD147 sensitizes human malignant melanoma cells to hydrogen peroxide-induced oxidative stress2010
Author(s)
Li J, Peng L, Wu L, Kuang Y, Su J, Yi M, Hu X, Li D, Xie H, Kanekura T, Chen X.
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Journal Title
J Dermatol Sci
Volume: 58
Pages: 204-10
NAID
Related Report
Peer Reviewed
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[Presentation] 皮膚と紫外線2012
Author(s)
金蔵拓郎
Organizer
平成24年鹿児島県薬剤師会新春学術講演会
Place of Presentation
鹿児島市(招待講演)
Year and Date
2012-01-15
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