Elucidation of the resistance mechanisms of immunotherapy by the abnormal signal transduction in melanoma and development of methods to overcome it
| Project/Area Number |
21591445
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tomonobu 慶應義塾大学, 医学部, 助教 (20199334)
TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117)
KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
|
|---|
| Research Collaborator |
KAWAMURA Naoshi 慶應義塾大学, 医学部, 博士 (30570246)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 皮膚腫瘍学 / 悪性黒色腫 / 免疫抑制 / 免疫療法 / シグナル伝達異常 / 樹状細胞 / シグナル伝達 |
|---|
| Research Abstract |
In this study, we have attempted to identify new signaling molecules which trigger multiple immunosuppressive and tumor promoting cytokines and chemokines. By screening dendritic cell(DC) suppressing activity of culture supernatants from the human melanoma cell line treated with human kinase siRNA library, we found 7 kinases. One of them, Serine/Threonine kinase 24(STK24), was found to induce production of IL10, TGF-β, and CCL2 by human melanoma cells. Phosphorylated STK24 was increased in various human melanoma cell lines and melanoma tissue. These results indicate that activated STK24 in cancer cells is involved in the generation of tumor promoting and immunosuppressive tumor microenvironment.
|
Report
(4 results)
Research Products
(29 results)
-
-
[Journal Article]2011
Author(s)
Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y
-
Journal Title
Int J Hematol
Volume: Vol.93, No.3
Pages: 294-300
Related Report
Peer Reviewed
-
-
-
[Journal Article] Aberrant Fatty Acid-Binding Protein 7 Gene Expression In Cutaneous Malignant Melanoma2010
Author(s)
Goto Y, Koyanagi K, Narita N, Kawakami Y, Takata M, Uchiyama A, Nguyen L, Nguyen T, Morton DL, Hoon D
Volume
Vol.130, No.1
Pages
221-229
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] がん免疫逃避機構とその制御2011
Author(s)
河上裕、塚本信夫, その他
Organizer
第15回日本がん免疫学会総会
Place of Presentation
大阪府・千里ライフサイエンスセンター、大阪
Year and Date
2011-07-01
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
