| Project/Area Number |
21591446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
|
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| Research Institution | Tokai University |
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Principal Investigator |
OZAWA Akira 東海大学, 医学部, 教授 (20096209)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEKOSHI Susumu 東海大学, 医学部, 准教授 (70216878)
IKOMA Norihiro 東海大学, 医学部, 講師 (40407979)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚病理学 / 酸化ストレス / 乾癬 / 増殖・分化異常 / MAPキナーゼ / 幹細胞マーカー / シグナル伝達 / 慢性炎症性皮膚疾患 / ヒト皮膚組織 / 紫外線 / 抗酸化酵素 / レーザーマイクロダイセクション |
|---|
| Research Abstract |
Intended for human skin tissue was exposed to sunlight long period of time, we analyzed that oxidative stress injury, the expression of antioxidant enzymes and oxidative stress signaling. As a result, oxidative DNA is a marker of nucleic acid damage by reactive oxygen species showed no change. On the other hand, HNE become a marker of lipid peroxidation was increased. HNE is not co-localized with collagen, but co-localized with elastin. Also, in a variety of antioxidant enzymes, induction of HO-2 expression is non-inductive type is made for the first time became clear. In addition, we were investigated by using the skin lesions of psoriasis skin disease as a model. Cells were co-localized with A and B had failed oxidative stress. The failed cell oxidative stress was correlated with BSA which is a measure of the skin lesions of psoriasis.
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