Effective systems delivering drugs to the skin using nanoneedle

• Project/Area Number: 21591452
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: HANADA Katsumi 弘前大学, 医学部・附属病院, 病院長 (80091627)
• Co-Investigator(Kenkyū-buntansha): SAWAMUERA Daisuke 弘前大学, 大学院・医学研究科, 教授 (60196334) ; MATSUZAKI Yasushi 弘前大学, 医学部附属病院, 講師 (50322946)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ナノニードル / 皮膚 / 核酸 / 蛋白質 / 合成化合物 / デフェンシン / フィラグリン / 治療

Research Abstract

Development of the delivery systems which can introduce therapeutic molecules into targeting organs surely make a progress of treatments in clinical practice. We pay strong attention to a nanoneedle method. The needles containing drugs go into the skin, are broken, are remained and release the drugs to the skin. In this study, we first examined the appropriate length of the needle and then checked material properties of the needle. Next, we tried to introduce some dye into skin using the nanoneedles and we found the dye in the skin. However, introducing rate was not enough for protein and genes in the aspect of clinical use and we need to improve the introducing rate. In conclusion, this method is suggested to be potential for delivering the molecules into the skin.

Research Products

• [Journal Article] Pemphigus Study Group. A randomized double-blind trial of intravenous immunoglobulin for pemphigus (2009)
  • Author(s): Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K
  • Journal Title: J Am Acad Dermatol Volume: 60(4) Pages: 595-603
  • URL: http://www.sciencedirect.com/science/article/pii/S0190962208012401
  • Peer Reviewed
• [Journal Article] Localized pagetoid reticulosis (Woringer-Kolopp disease) in early childhood. (2009)
  • Author(s): Matsuzaki Y, Kimura K, Nakano H, Hanada K, Sawamura D.
  • Journal Title: J Am Acad Dermatol Volume: 61(1) Pages: 120-123
  • URL: http://www.sciencedirect.com/science/article/pii/S0190962208013741
  • Peer Reviewed
• [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus. (2009)
  • Author(s): Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K., et al.
  • Journal Title: J Am Acad Dermatol 60(4) Pages: 595-603
  • Peer Reviewed
• [Journal Article] Localized pagetoid reticulosis(Woringer-Kolopp disease)in early childhood. (2009)
  • Author(s): Matsuzaki Y, Kimura K, Nakano H, Hanada K, Sawamura D
  • Journal Title: J Am Acad Dermatol. 61(1) Pages: 120-123
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 花田勝美
  • Journal Title: 皮膚疾患診療実践ガイド(文光堂)
• [Book] 教師のための紫外線講座-紫外線が子どもをねらう (2010)
  • Author(s): 花田勝美
  • Total Pages: 88
  • Publisher: 弘前大学出版協会
• [Book] 教師のための紫外線講座-紫外線が子どもをねらう- (2010)
  • Author(s): 花田勝美
  • Total Pages: 88
  • Publisher: 弘前大学出版協会
• [Book] 皮膚疾患診療実践ガイド (2009)
  • Author(s): 花田勝美
  • Publisher: 文光堂