Development of the new wound medical treatment strategy by induction of epithelial mesenchymal transition (EMT)

• Project/Area Number: 21591453
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: AIZU Takayuki 弘前大学, 大学院・医学研究科, 助教 (00400135)
• Co-Investigator(Kenkyū-buntansha): NAKANO Hasjime 弘前大学, 大学院・医学研究科, 准教授 (90281922) ; SAWAMUERA Daisuke 弘前大学, 大学院・医学研究科, 教授 (60196334)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 上皮-間葉転換 / Snail / 創傷治癒 / 表皮細胞 / 線維芽細胞 / 転換 / 酵素 / 遺伝子 / 潰瘍 / 皮膚 / 治療 / 表紙細胞

Research Abstract

The ulcer was formed behind the rat and the ulcer treatment experiment for the animal using siRNA and DNA decoy of Snail which were examined in the human cell was conducted. As a result, a possibility that the contractionary effect of a skin ulcer and the various gene expression by suppressing Snail of the transcription factor which is a master gene which adjusts epithelial mesenchymal transition would change was suggested.

Research Products

• [Journal Article] Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation (2010)
  • Author(s): Takemoto H, Tamai K, Akasaka E, Rokunohe S, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D
  • Journal Title: J Dermatol Sci Volume: 60(3) Pages: 203-205
  • NAID: 10027841207
  • URL: http://dx.doi.org/10.1016/j.jdermsci.2010.10.006
  • Peer Reviewed
• [Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma (2010)
  • Author(s): Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D
  • Journal Title: J Dermatol Sci Volume: 60(3) Pages: 199-201
  • NAID: 10027841189
  • URL: http://dx.doi.org/10.1016/j.jdermsci.2010.10.005
  • Peer Reviewed
• [Journal Article] Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis (2010)
  • Author(s): Kimura Y, Kaneko T, Akasaka E, Nakajima K, Aizu T, Nakano H, Sawamura D
  • Journal Title: EUR J Dermatol Volume: 20(4) Issue: 4 Pages: 1-2
  • DOI: 10.1684/ejd.2010.0981
  • Peer Reviewed