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Analysis of novel homeostatic regulator of the skin.

Research Project

Project/Area Number 21591464
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionOsaka University

Principal Investigator

KATAYAMA Ichiro  Osaka University, 医学系研究科, 教授 (80191980)

Co-Investigator(Kenkyū-buntansha) KIRA Masahiro  大阪大学, 大学院・医学系研究科, 講師 (90314335)
MTROTA Hiroyuki  大阪大学, 大学院・医学系研究科, 助教 (90363499)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords皮膚生理学 / 11βHSD1と皮膚の恒常性 / グルココルチコイド / アレルギー / 発ガン / 11βHSD1 / 皮膚の恒常性と分化 / EGF / ケラチン10 / インボルクリン / 皮膚癌
Research Abstract

The role of 11βHSD1 in skin homeostasis was studied. The mRNA expression and protein level of 11βHSD1 increased by stimuli, such as UVB, haptens, and TNFα. 11βHSD1 knockdown by si11βHSD1 and 11βHSD1 inhibition by specific inhibitor suppressed differentiation of keratinocytes and enhanced proliferation. In vivo studies, selective inhibitor of 11βHSD1 promoted cutaneous wound healing. Taken together, we consider that 11βHSD1 acting as a regulator of keratinocytes proliferation and differentiation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (48 results)

All 2011 2010 2009

All Journal Article (38 results) (of which Peer Reviewed: 36 results) Presentation (10 results)

  • [Journal Article] Multiple lymphadenopathy as an initial sign of extramammary Paget's disease.2011

    • Author(s)
      Hirakawa S, Katayama I
    • Journal Title

      British Journal of Dermatology 164

      Pages: 200-203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses.2011

    • Author(s)
      中川幸延, 片山一朗
    • Journal Title

      Journal of Immunology

      Volume: Vol.186 Pages: 2881-2888

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple lymphadenopathy as an initial sign of extramammary Paget's disease.2011

    • Author(s)
      Hirakawa S, Katayama I
    • Journal Title

      British Journal of Dermatology

      Volume: 64(1) Pages: 200-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses.2010

    • Author(s)
      中川幸延, 片山一朗
    • Journal Title

      Journal of Immunology 186

      Pages: 2881-2888

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Olopatadine hydrochloride improves dermatitis score and inhibits scratch behavior in NC/Nga mice.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      Int Arch Allergy Immunol 153

      Pages: 121-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous symptoms in a patient with cardiofaciocutaneous syndrome and increased ERK phosphorylation in skin fibroblasts.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Journal Title

      British Journal of Dermatology 163

      Pages: 881-884

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      British Journal of Dermatology 163

      Pages: 128-137

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Good's syndrome (hypogammaglobulinemia with thymoma) presenting intractable opportunistic infections and hyperkeratotic lichen planus.2010

    • Author(s)
      花房崇明, 片山一朗
    • Journal Title

      Journal of Dermatology 37

      Pages: 171-174

    • NAID

      10027065837

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.2010

    • Author(s)
      片山一朗
    • Journal Title

      Nat Immunol.

      Pages: 594-600

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum anti-BPAG1 auto-antibody is a novel marker for human melanoma.2010

    • Author(s)
      Shimbo T, Katayama I
    • Journal Title

      PLoS One.5 5

      Pages: 10566-10566

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      Allergy 65

      Pages: 929-930

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Journal Title

      Exp Dermatol. 19

      Pages: 38-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab.2010

    • Author(s)
      Shima Y, Katayama I
    • Journal Title

      Rheumatology(Oxford) doi : 10.1093 Online

      Pages: 1-5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Olopatadine hydrochloride improves dermatitis score and inhibits scratch behavior in NC/Nga mice.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      Int Arch Allergy Immunol

      Volume: Vol.153 Pages: 121-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous symptoms in a patient with cardiofaciocutaneous syndrome and increased ERK phosphorylation in skin fibroblasts.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Journal Title

      British Journal of Dermatology

      Volume: Vol.163 Pages: 881-884

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      British Journal of Dermatology

      Volume: Vol.163 Pages: 128-137

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Good's syndrome(hypogammaglobulinemia with thymoma) presenting intractable opportunistic infections and hyperkeratotic lichen planus.2010

    • Author(s)
      花房崇明, 片山一朗
    • Journal Title

      Journal of Dermatology

      Volume: Vol.37 Pages: 171-174

    • NAID

      10027065837

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab.2010

    • Author(s)
      Shima Y, Katayama I
    • Journal Title

      Rheumatology (Oxford)

      Volume: 49(12) Pages: 2408-12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.2010

    • Author(s)
      Katayama I
    • Journal Title

      Nat Immunol.

      Volume: Vol.11 Pages: 594-600

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum anti-BPAG1 auto-antibody is a novel marker for human melanoma.2010

    • Author(s)
      Shimbo T, Katayama I
    • Journal Title

      PLoS One.

      Volume: 5(5)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases.2010

    • Author(s)
      室田浩之, 片山一朗
    • Journal Title

      Allergy

      Volume: Vol.65 Pages: 929-930

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in ableomycin-induced murine model of scleroderma.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Journal Title

      Exp Dermatol.

      Volume: Vol.19 Pages: 38-43

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma2010

    • Author(s)
      Terao M, Murota H, Kitaba S, Katayama I
    • Journal Title

      Exp Dermatol 19

      Pages: 38-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nodal lymphangiogenesis and metastasis : Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease2009

    • Author(s)
      Hirakawa S, 他18名(18番目)
    • Journal Title

      Am J Pathol 175

      Pages: 2235-48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emedastine difumarate : a review of its potential ameliorating effect for tissue remodeling in allergic diseases2009

    • Author(s)
      Murota H, Katayama I
    • Journal Title

      Expert Opin Pharmacother 10

      Pages: 1859-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for management of atopic dermatitis2009

    • Author(s)
      Saeki H, 他8名(6番目)
    • Journal Title

      J Dermatol 36(10)

      Pages: 563-577

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus2009

    • Author(s)
      Amagai M, 他29名(15番目)
    • Journal Title

      Journal of the American Academy of Dermatology 60(4)

      Pages: 595-603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of schwannomatosis2009

    • Author(s)
      Murakami Y, Wataya-Kaneda M, Tanaka M, Myoui A, Sakata Y, Katayama I.
    • Journal Title

      J Dermatol 36(9)

      Pages: 508-511

    • NAID

      10027064248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of recurrent urticaria in a patient with Schnitzler syndrome associated with B-cell lymphoma with combination rituximab and radiotherapy2009

    • Author(s)
      Murota H, Shoda Y, Ishibashi T, Sugahara H, Matsumura I, Katayama I.
    • Journal Title

      J Am Acad Dermatol 61(6)

      Pages: 1070-1075

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent contact cheilitis because of glyceryl isostearate, diisostearyl maleate, oleyl alcohol, and Lithol Rubine BCA in lipsticks2009

    • Author(s)
      Inui S, Azukizawa H, Katayama I.
    • Journal Title

      Contact Dermatitis 60(4)

      Pages: 231-232

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intractable wounds caused by pyoderma gangrenosum in a patient with critical limb ischemia treated with cyclosporine and adjuvant sympathectomy2009

    • Author(s)
      Takahashi Y, Yamaguchi Y, Itoh K, Sano S, Morita A, Katayama I.
    • Journal Title

      Dermatol Surg 35(4)

      Pages: 699-703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎とリモデリング2009

    • Author(s)
      片山一朗, 室田浩之
    • Journal Title

      臨床免疫・アレルギー科 52(1)

      Pages: 78-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 : アレルギー疾患のQOL障害各論 アトピー性皮膚炎患者のQOL~汗対策/痒み対策を中心に~2009

    • Author(s)
      室田浩之, 北場俊, 片山一朗
    • Journal Title

      アレルギー・免疫 16(12)

      Pages: 58-65

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説 : Sjogren 症候群の環状紅斑2009

    • Author(s)
      片山一朗
    • Journal Title

      皮膚病診療 31(12)

      Pages: 1372-1378

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚のストレス応答から考えるアトピー性皮膚炎の治療指針2009

    • Author(s)
      片山一朗, 室田浩之, 北場俊
    • Journal Title

      皮膚の科学 8(Sup 12)

      Pages: 595-601

    • NAID

      130004934565

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎患者における前向きアンケート調査の開始時基礎情報 (第1報)2009

    • Author(s)
      古江増隆, 他13名(11番目)
    • Journal Title

      臨床皮膚科 63(6)

      Pages: 433-441

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      片山一朗, 他6名(筆頭)
    • Journal Title

      Targeting STATE in atopic eczema/dermatitis in [Allergy Frontiers](Springer ed by Ruby Pawankar, StephenT Holgate, Lanny J Rosenwasser)

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      片山一朗
    • Journal Title

      皮膚科レジデント・戦略ガイド編集宮地良樹(診断と治療社)

    • Related Report
      2009 Annual Research Report
  • [Presentation] 11β-hydroxysteroid dehydrogenase-1 is strongly expressed in differentiated keratinocytes and regulates epidermal turnover.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 11β-hydroxysteroid dehydrogenase-1 is strongly expressed in differentiated keratinocytes and regulates epidermal turnover2010

    • Author(s)
      寺尾美香, 片山一朗
    • Organizer
      第25回 角化症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 11β-HSD as a novel regulator of epidermal differentiation : Considering the possible involvement in aberrant keratinizating disorders.2010

    • Author(s)
      寺尾美香, 片山一朗
    • Organizer
      第35回日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Final Research Report
  • [Presentation] 11β-HSD as a novel regulator of epidermal differentiation : Considering the possible involvement in aberrant keratinizating disorders2010

    • Author(s)
      寺尾美香, 片山一朗
    • Organizer
      第35回 日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 汗とアレルギー2009

    • Author(s)
      片山一朗
    • Organizer
      TAMS (多摩地区アレルギー・免疫セミナー)
    • Place of Presentation
      東京
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 皮膚の栄養学とアレルギー2009

    • Author(s)
      片山一朗
    • Organizer
      静岡県皮膚科医会第133回例会
    • Place of Presentation
      静岡
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] New aspect of allergic contact dermatitis. What's true and new in immunology of contact dermatitis2009

    • Author(s)
      片山一朗
    • Organizer
      17th International contact dermatitis symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural and inflammatory aspects of itch responses in atopic dermatitis : New action mechanism of anti-histaminic drug on mite antigen-induced skin lesions in NC/Nga mice2009

    • Author(s)
      片山一朗
    • Organizer
      5th International Workshop for the Study of Itch Atopic Dermatitis Luncheon Seminar
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] かゆみ治療を考える~Work Productivity and Activity Impairment (WPAI) の視点から~2009

    • Author(s)
      片山一朗
    • Organizer
      第5回神奈川皮膚アレルギー疾患研究会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギー性皮膚疾患と環境因子2009

    • Author(s)
      片山一朗
    • Organizer
      日本産業皮膚衛生協会 講演会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-19
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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