| Project/Area Number |
21591467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kochi University |
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Principal Investigator |
NAKAJIMA Kimiko 高知大学, 教育研究部・医療学系, 講師 (20403892)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Shigetoshi 高知大学, 教育研究部・医療学系, 教授 (80273621)
TAKAISHI Mikiro 高知大学, 教育研究部・医療学系, 助教 (10303223)
MIYOSHI Ken 高知大学, 教育研究部・医療学系, 助教 (20274392)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 乾癬 / Th17 / モデルマウス / Stat3 / IL23/Th17 / バイオロジックス / IL-23 |
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| Research Abstract |
In this study, we characterized the effects of anti-mouse IL-17A, anti-mouse IL-12/ 23p40, and anti-mouse IL-23p19 Abs on the development of psoriasis-like lesions in K5. Stat3C transgenic mice. Treatment with anti-IL-12/ 23p40 or anti-IL-23p19 Abs greatly inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia in the ears of K5. Stat3C mice, whereas the inhibitory effect of an anti-IL-17A Ab was relatively less prominent. Taken together, this system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL-23 and IL-17.
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