The role of Th17 in the pathogenesis of psoriasis

• Project/Area Number: 21591467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kochi University
• Principal Investigator: NAKAJIMA Kimiko 高知大学, 教育研究部・医療学系, 講師 (20403892)
• Co-Investigator(Kenkyū-buntansha): SANO Shigetoshi 高知大学, 教育研究部・医療学系, 教授 (80273621) ; TAKAISHI Mikiro 高知大学, 教育研究部・医療学系, 助教 (10303223) ; MIYOSHI Ken 高知大学, 教育研究部・医療学系, 助教 (20274392)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 乾癬 / Th17 / モデルマウス / Stat3 / IL23/Th17 / バイオロジックス / IL-23

Research Abstract

In this study, we characterized the effects of anti-mouse IL-17A, anti-mouse IL-12/ 23p40, and anti-mouse IL-23p19 Abs on the development of psoriasis-like lesions in K5. Stat3C transgenic mice. Treatment with anti-IL-12/ 23p40 or anti-IL-23p19 Abs greatly inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia in the ears of K5. Stat3C mice, whereas the inhibitory effect of an anti-IL-17A Ab was relatively less prominent. Taken together, this system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL-23 and IL-17.

Research Products

• [Journal Article] The critical role of the IL-23/Th17 axis in the pathogenesis of psoriasis. Review (2012)
  • Author(s): Nakajima K.
  • Journal Title: J Dermatol Volume: 39 Pages: 219-224
  • Peer Reviewed
• [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model (2011)
  • Author(s): Nakajima K, K. Kanda T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
  • Journal Title: J Immnuol Volume: 186 Pages: 4481-9
• [Journal Article] 自己免疫性疾患としての乾癬病態と治療: Th17と乾癬 (2011)
  • Author(s): 中島喜美子, 佐野栄紀
  • Journal Title: アレルギー・免疫 Volume: 18 Pages: 33-38
• [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model (2011)
  • Author(s): Nakajima K, K.Kand T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
  • Journal Title: J Immnuol Volume: 186 Pages: 4481-4489
  • Peer Reviewed
• [Journal Article] Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model (2011)
  • Author(s): Kimiko Nakajima, Takashi Kanda, et al.
  • Journal Title: The Journal of Immunology Volume: 186 Pages: 4481-4489
  • Peer Reviewed
• [Journal Article] Th17と乾癬 (2011)
  • Author(s): 中島喜美子、佐野栄紀
  • Journal Title: アレルギー・免疫 Volume: 18 Pages: 33-38
• [Journal Article] The critical role of the IL-23/ Th17 axis in the pathogenesis of psoriasis.
  • Author(s): Nakajima K
  • Journal Title: Review. J Dermatol Volume: (in press)
• [Presentation] The possible contribution of IL-22-producing-non-T cells in the development of psoriasis-like lesions in the mouse model (2010)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
  • Year and Date: 2010-12-04
• [Presentation] The possible contribution of IL-22-producing-non-T cells in the development of psoriasis-like lesions in the mouse model. (2010)
  • Author(s): Nakajima K, et al.
  • Organizer: The 35th annual meetings of the JSID
  • Place of Presentation: 和歌山県民文化会館(和歌山)
  • Year and Date: 2010-12-04
• [Presentation] The crosstalk between IL-17, IL-22 and keratinocytes in development of psoriasis-like lesions in a mouse model (2010)
  • Author(s): Nakajima K, Tateo Shiga, Mikiro Takaishi, Ken Miyoshi, Shigetoshi Sano
  • Organizer: 第24回表皮細胞研究会
  • Place of Presentation: 高知
  • Year and Date: 2010-10-09
• [Presentation] 乾癬モデルマウス(K5. Stat3C transgenic mice)におけるIL-23/ Th17axisについて (2010)
  • Author(s): 中島喜美子,佐野栄紀
  • Organizer: 第25回日本乾癬学会シンポジウム
  • Place of Presentation: 宇部
  • Year and Date: 2010-09-03
• [Presentation] 乾癬モデルマウスにおけるTh17について (2010)
  • Author(s): 中島喜美子
  • Organizer: 第25回日本乾癬学会学術大会 シンポジウム
  • Place of Presentation: 宇部全日空ホテル(山口)
  • Year and Date: 2010-09-03
• [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model : anti-IL-6R antibody had no inhibitory effect for the development of lesion (2010)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
  • Organizer: The 14^<th> international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-28
• [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model : anti-IL-6R antibody had no inhibitory effect for the development of lesion. (2010)
  • Author(s): Nakajima K, et al.
  • Organizer: The 14^<th> international congress of immunology
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場(神戸)
  • Year and Date: 2010-08-23
• [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model. (2010)
  • Author(s): Nakajima K, et al.
  • Organizer: The 70^<th> SID annual meeting
  • Place of Presentation: Hilton Atlanta(USA)
  • Year and Date: 2010-05-07
• [Presentation] The Distinct role in the development of psoriasis-likelesion in K5.Stat3C mice (2010)
  • Author(s): 中島喜美子
  • Organizer: Society for Investigative Dermatology
  • Place of Presentation: Hilton Atlanta(Atlata)アメリカ
  • Year and Date: 2010-05-07
• [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model (2010)
  • Author(s): Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
  • Organizer: The 70^<th> SID annual meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2010-05-05
• [Presentation] 自然免疫と乾癬・アトピー性皮膚炎 (2010)
  • Author(s): 中島喜美子
  • Organizer: 第109回日本皮膚科学会総会教育講習会
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-18
• [Presentation] Development of psoriasis is dependent on IL-12/ 23p40, but partially on IL-17A in a mouse model (2009)
  • Author(s): Takaishi M, Nakajima K, DiGiovanni J, Iwakura Y, Sano S
  • Organizer: The 3^<9th> ESDR annual meeting
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-09-09
• [Presentation] 乾癬モデルマウスにおけるTh17の関与について (2009)
  • Author(s): 中島喜美子,高石樹朗,三好研,佐野栄紀
  • Organizer: 第24回日本乾癬学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-04
• [Presentation] 乾癬モデルマウスにおけるTh17の関与について (2009)
  • Author(s): 中島喜美子, 高石樹朗, 三好研, 佐野栄紀
  • Organizer: 第24回日本乾癬学会学術大会
  • Place of Presentation: 東海大校友会館(東京)
  • Year and Date: 2009-09-04