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The role of Th17 in the pathogenesis of psoriasis

Research Project

Project/Area Number 21591467
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKochi University

Principal Investigator

NAKAJIMA Kimiko  高知大学, 教育研究部・医療学系, 講師 (20403892)

Co-Investigator(Kenkyū-buntansha) SANO Shigetoshi  高知大学, 教育研究部・医療学系, 教授 (80273621)
TAKAISHI Mikiro  高知大学, 教育研究部・医療学系, 助教 (10303223)
MIYOSHI Ken  高知大学, 教育研究部・医療学系, 助教 (20274392)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords乾癬 / Th17 / モデルマウス / Stat3 / IL23/Th17 / バイオロジックス / IL-23
Research Abstract

In this study, we characterized the effects of anti-mouse IL-17A, anti-mouse IL-12/ 23p40, and anti-mouse IL-23p19 Abs on the development of psoriasis-like lesions in K5. Stat3C transgenic mice. Treatment with anti-IL-12/ 23p40 or anti-IL-23p19 Abs greatly inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia in the ears of K5. Stat3C mice, whereas the inhibitory effect of an anti-IL-17A Ab was relatively less prominent. Taken together, this system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL-23 and IL-17.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (14 results)

  • [Journal Article] The critical role of the IL-23/Th17 axis in the pathogenesis of psoriasis. Review2012

    • Author(s)
      Nakajima K.
    • Journal Title

      J Dermatol

      Volume: 39 Pages: 219-224

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2011

    • Author(s)
      Nakajima K, K. Kanda T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
    • Journal Title

      J Immnuol

      Volume: 186 Pages: 4481-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] 自己免疫性疾患としての乾癬病態と治療: Th17と乾癬2011

    • Author(s)
      中島喜美子, 佐野栄紀
    • Journal Title

      アレルギー・免疫

      Volume: 18 Pages: 33-38

    • Related Report
      2011 Final Research Report
  • [Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2011

    • Author(s)
      Nakajima K, K.Kand T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
    • Journal Title

      J Immnuol

      Volume: 186 Pages: 4481-4489

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model2011

    • Author(s)
      Kimiko Nakajima, Takashi Kanda, et al.
    • Journal Title

      The Journal of Immunology

      Volume: 186 Pages: 4481-4489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17と乾癬2011

    • Author(s)
      中島喜美子、佐野栄紀
    • Journal Title

      アレルギー・免疫

      Volume: 18 Pages: 33-38

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The critical role of the IL-23/ Th17 axis in the pathogenesis of psoriasis.

    • Author(s)
      Nakajima K
    • Journal Title

      Review. J Dermatol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Presentation] The possible contribution of IL-22-producing-non-T cells in the development of psoriasis-like lesions in the mouse model2010

    • Author(s)
      Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
    • Organizer
      第35回日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The possible contribution of IL-22-producing-non-T cells in the development of psoriasis-like lesions in the mouse model.2010

    • Author(s)
      Nakajima K, et al.
    • Organizer
      The 35th annual meetings of the JSID
    • Place of Presentation
      和歌山県民文化会館(和歌山)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The crosstalk between IL-17, IL-22 and keratinocytes in development of psoriasis-like lesions in a mouse model2010

    • Author(s)
      Nakajima K, Tateo Shiga, Mikiro Takaishi, Ken Miyoshi, Shigetoshi Sano
    • Organizer
      第24回表皮細胞研究会
    • Place of Presentation
      高知
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 乾癬モデルマウス(K5. Stat3C transgenic mice)におけるIL-23/ Th17axisについて2010

    • Author(s)
      中島喜美子,佐野栄紀
    • Organizer
      第25回日本乾癬学会シンポジウム
    • Place of Presentation
      宇部
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 乾癬モデルマウスにおけるTh17について2010

    • Author(s)
      中島喜美子
    • Organizer
      第25回日本乾癬学会学術大会 シンポジウム
    • Place of Presentation
      宇部全日空ホテル(山口)
    • Year and Date
      2010-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model : anti-IL-6R antibody had no inhibitory effect for the development of lesion2010

    • Author(s)
      Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
    • Organizer
      The 14^<th> international congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model : anti-IL-6R antibody had no inhibitory effect for the development of lesion.2010

    • Author(s)
      Nakajima K, et al.
    • Organizer
      The 14^<th> international congress of immunology
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model.2010

    • Author(s)
      Nakajima K, et al.
    • Organizer
      The 70^<th> SID annual meeting
    • Place of Presentation
      Hilton Atlanta(USA)
    • Year and Date
      2010-05-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Distinct role in the development of psoriasis-likelesion in K5.Stat3C mice2010

    • Author(s)
      中島喜美子
    • Organizer
      Society for Investigative Dermatology
    • Place of Presentation
      Hilton Atlanta(Atlata)アメリカ
    • Year and Date
      2010-05-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2010

    • Author(s)
      Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
    • Organizer
      The 70^<th> SID annual meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2010-05-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然免疫と乾癬・アトピー性皮膚炎2010

    • Author(s)
      中島喜美子
    • Organizer
      第109回日本皮膚科学会総会教育講習会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of psoriasis is dependent on IL-12/ 23p40, but partially on IL-17A in a mouse model2009

    • Author(s)
      Takaishi M, Nakajima K, DiGiovanni J, Iwakura Y, Sano S
    • Organizer
      The 3^<9th> ESDR annual meeting
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2009-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 乾癬モデルマウスにおけるTh17の関与について2009

    • Author(s)
      中島喜美子,高石樹朗,三好研,佐野栄紀
    • Organizer
      第24回日本乾癬学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 乾癬モデルマウスにおけるTh17の関与について2009

    • Author(s)
      中島喜美子, 高石樹朗, 三好研, 佐野栄紀
    • Organizer
      第24回日本乾癬学会学術大会
    • Place of Presentation
      東海大校友会館(東京)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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