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Challenge to the developmental study of new biomarker and new treatment in recalcitrant allergic skin disease

Research Project

Project/Area Number 21591471
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionInternational University of Health and Welfare (2011)
Yokohama City University (2009-2010)

Principal Investigator

IKEZAWA Zenro  国際医療福祉大学, 熱海病院皮膚科 (90046128)

Co-Investigator(Kenkyū-buntansha) 池澤 優子  横浜市立大学, 市民総合医療センター, 助教 (80457879)
山口 由衣  横浜市立大学, 医学部, 助教 (60585264)
國見 裕子  横浜市立大学, 附属病院, 助手 (10567605)
秦田 勇二  海洋研, 極限環境生物圏研究センター, グループ・リーダー (20399562)
相原 道子  横浜市立大学, 附属病院, 教授 (90231753)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアトピー性皮膚炎 / ドライスキン / 痒み / 皮表の黄色ブドウ球菌叢 / IL-18 / NGF / Semaphorin 3A(Sema3A) / アレルギー性鼻炎 / コラーゲントリペプチド(CTP) / アトピー性皮膚炎(AD) / super Th1細胞 / Semaphorin3A (Sema3A) / 皮膚バリアー機能異常 / 角層IL-18 / 皮膚黄色ブドウ球菌叢 / 内因性アトピー性皮膚炎 / 掻痒性乾癬とSemaphorin 3A / アレルギー鼻炎と痒み / 新規アレルギー鼻炎治療薬としてのSemaphorin 3A / 皮表の黄色ブドゥ球菌叢 / Semaphorin3A(Sema3A)
Research Abstract

1) IL-18 levels in the horny layer were significantly higher in the skin lesions of patients with AD than in healthy controls and correlated with SCORAD, levels of serum IL-18, IgE, lactate dehydrogenase(LDH), thymus and activation-regulated chemokine(TARC), blood eosinophils and transepidermal water loss(TEWL). In the AD group with serum IgE<1500 IU mL, significantly higher IL-18 levels were observed in the horny layer of patients colonized with S. aureus compared with those who were not. From these results, it may be concluded that epidermal IL-18 production is associated with the severity of AD, that staphylococcus aureus colonization seems to contribute to this IL-18 production, especially in the AD group with relatively low IgE production, and that tape stripping provides an easy and noninvasive method to assess epidermal IL-18 production by ELISA. 2-1) Pruritus is a common symptom of psoriasis, which affects quality of life. This symptom accompanies the hyperinnervation of sensor … More y C-fibres in psoriatic lesions. Two extracellular molecules, nerve growth factor(NGF) and semaphorin-3A, regulate C-fibre extension. In this study, the expression levels of these 2 molecules in biopsy specimens from psoriatic and healthy skin were quantified by immune-histochemistry and quantitative reverse-transcription PCR. Semaphorin-3A expression was lower in the psoriatic samples compared with the healthy samples, whereas NGF was higher. C-fibre innervation in the epidermis was also increased in psoriatic skin. Semaphorin-3A mRNA expression was negatively correlated with itch intensity and severity of psoriasis. We propose that decreased semaphorin-3A and increased NGF expression levels may trigger the outgrowth of C-fibres, leading to pruritus. 2-2) Sneezing and persistent itching of the nasal mucosa are distressing symptoms of allergic rhinitis(AR). Recent studies have revealed that hyperinnervation of sensory neurons in the nasal turbinate is one of the underlying causes of sneezing and itching. Since Semaphorin-3A(Sema3A) has been previously shown to restrict innervation of sensory neurons, it is presumed that reduced Sema3A expression in the nasal mucosa might contribute to the hypersensitivity. Analysis of the mouse model of ovalbumin-sensitized AR demonstrated a decreased expression of Sema3A in the nasal epithelium, which was accompanied by an increased nerve fiber density in the lamina propria of the turbinate. In rescue experiments, intranasal administration of recombinant Sema3A in the AR model mice alleviated sneezing and nasal rubbing symptoms. In addition, histological examinations also revealed that nerve fiber density was decreased in the lamina propria of the Sema3A-treated nasal turbinate. These results suggest that the nasal hypersensitivity of AR may be attributed to reduction of Sema3A expression and intranasal administration of Sema3A may provide a novel approach to alleviate the allergic symptoms for AR treatment. 3) CTP enhanced hyaluronic acid production in human dermal fibroblasts in vitro and in murine skin in vivo. Oral administration of CTP in acetone-induced dry skin model mice significantly decreased TEWL and suppressed scratching behavior. Intraepidermal nerve growth was dramatically inhibited in CTP-treated mice. Quantitative PCR analysis and immunohistochemical study revealed that CTP abolished the increased NGF and decreased Sema3A levels induced by acetone treatment. From these results, it may be concluded that oral administration of CTP improves dry skin and normalizes axon-guidance factors in the epidermis in addition to reducing pruritus. CTP may be used in a new therapeutic strategy against dry skin and pruritus. Less

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (85 results)

All 2012 2011 2010 2009 2008

All Journal Article (38 results) (of which Peer Reviewed: 13 results) Presentation (46 results) Book (1 results)

  • [Journal Article] Decreased Expression of Semaphorin-3A, a Neurite-Collapsing Factor, is Associated With Itch in Psoriatic Skin2012

    • Author(s)
      Kou K, Nakamura F, Aihara M, Chen H, Seto K, Komuri-Yamaguchi J, Kambara T, Nagashima Y, Goshima Y and Ikezawa Z
    • Journal Title

      Acta Derm Venereol

      Volume: 92(Accepted)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model2012

    • Author(s)
      Okawa T, Yamaguchi Y, Takada S, Sakai Y, Numata N, Nakamura F, Nagashima Y, Ikezawa Z, Aihara M
    • Journal Title

      J Dermatol Sci

      Volume: 66(2) Pages: 136-143

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis2012

    • Author(s)
      Kou K, Aihara M, Matsunaga T, Chen H, Taguri M, Morita S, Fujita H, Yamaguchi Y, Kambara T, Ikezawa Z
    • Journal Title

      Arch Dermatol Res

      Volume: 304 Pages: 305-312

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis(学位論文)2011

    • Author(s)
      Kou K, Aihara M, Matsunaga T, Chen H, Taguri M, Morita S, Fujita H, Yamaguchi Y, Kambara T, Ikezawa Z
    • Journal Title

      Arch Dermatol Res

    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of dermatomyositis-specific autoantibodies and clinical characteristics in Japanese patients2011

    • Author(s)
      Ikeda N, Takahashi K, Yamaguchi Y, Inasaka M, Kuwana M, Ikezawa Z
    • Journal Title

      J Dermatol

      Volume: 38(10) Pages: 973-979

    • NAID

      10031147110

    • Related Report
      2011 Final Research Report
  • [Journal Article] Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis2011

    • Author(s)
      Sawaki H, Nakamura F, Aihara M, Nagashima Y, Komori-Yamaguchi J, Yamashita N, Nakazawa M, Goshima Y, Ikezawa Z
    • Journal Title

      J Pharmacol Sci

      Volume: 117(1) Pages: 34-44

    • NAID

      10029895884

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Genome-wide association study identifies HLA-A* 3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population2011

    • Author(s)
      Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, Ikezawa Z, Iijima M, Shiohara T, Hashimoto K, Kamatani N, Nakamura Y
    • Journal Title

      Hum Mol Genet.

      Volume: 20(5) Pages: 1034-1041

    • Related Report
      2011 Final Research Report
  • [Journal Article] Interleukin-18 is elevated in the horny layer in atopic dermatitis patients and associated with Staphylococcus aureus colonization;2011年度World congress of Dermatology 2011 E-Poster Gold prize)2011

    • Author(s)
      Inoue Y, Aihara M, Kirino M, Harada I, Komori-Yamaguchi J, Yamaguchi Y, Nagashima Y, Ikezawa Z
    • Journal Title

      Br J Dermatol

      Volume: 64(3) Pages: 560-567

    • Related Report
      2011 Final Research Report
  • [Journal Article] 経皮感作による食物アレルギー、特集II食物アレルギー研究のこれからの展望2011

    • Author(s)
      松倉節子、相原道子、池澤善郎
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56(6) Pages: 684-693

    • Related Report
      2011 Final Research Report
  • [Journal Article] 食物アレルギーの発症と経皮感作、アレルギー疾患~感作と発症のからくり~2011

    • Author(s)
      松倉節子、相原道子、池澤善郎
    • Journal Title

      臨床現場からとらえた感作と発症、アレルギー・免疫

      Volume: 19(1) Pages: 46-55

    • Related Report
      2011 Final Research Report
  • [Journal Article] ALLAZINE Liveアレルギー最前線「感作と発症アレルゲンの隠された関係、OAS(Oral Allergy Syndrome)」2011

    • Author(s)
      池澤善郎
    • Journal Title

      ALLAZINE, Allergy News

    • Related Report
      2011 Final Research Report
  • [Journal Article] アレルギーマーチの進展をどのように予防するか、皮膚科の立場から-乳児期早期スキンケアがAD重症化防止-2011

    • Author(s)
      池澤善郎, 他
    • Journal Title

      Medical Tribune

    • Related Report
      2011 Final Research Report
  • [Journal Article] アトピー性皮膚炎の病勢を示す検査について;TARC, IL-18, NGFなどの検討から2011

    • Author(s)
      池澤善郎
    • Journal Title

      Info Allergy

      Volume: No.56 Pages: 5-5

    • Related Report
      2011 Final Research Report
  • [Journal Article] 重症薬疹と遺伝子型update2011

    • Author(s)
      池澤善郎
    • Journal Title

      医学のあゆみ

      Volume: 238(7, 8) Pages: 761-768

    • Related Report
      2011 Final Research Report
  • [Journal Article] 5.蕁麻疹2011

    • Author(s)
      池澤善郎
    • Journal Title

      総合臨床

      Volume: 60巻増刊号 Pages: 125-132

    • Related Report
      2011 Final Research Report
  • [Journal Article] アトピー性皮膚炎のもう一つ上のコントロールをめざして2011

    • Author(s)
      池澤善郎
    • Journal Title

      日本小児難治喘息・アレルギー疾患学会誌

      Volume: 9(3) Pages: 229-243

    • Related Report
      2011 Final Research Report
  • [Journal Article] アトピー性皮膚炎とその痒みの病態と治療の展望2011

    • Author(s)
      池澤善郎、井上雄介、池澤優子、蒲原毅
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56(3) Pages: 303-319

    • Related Report
      2011 Final Research Report
  • [Journal Article] 血管性浮腫の診断と治療の進歩2011

    • Author(s)
      池澤善郎
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55(3) Pages: 312-321

    • Related Report
      2011 Final Research Report
  • [Journal Article] アレルギー性接触皮膚炎の発症機序と病型と診断・治療、アレルギー花粉症からアナフィラキシーまで2011

    • Author(s)
      池澤善郎
    • Journal Title

      診断と治療(東京)

      Volume: 99(2) Pages: 271-281

    • Related Report
      2011 Final Research Report
  • [Journal Article] A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis2010

    • Author(s)
      Ikezawa Z, Komori J, Ikezawa Y, Inoue Y, Kirino M, Katsuyama M, Aihara M
    • Journal Title

      Allergy, Asthma & Immunology Research

      Volume: 2(4) Pages: 235-246

    • Related Report
      2011 Final Research Report
  • [Journal Article] Interleukin-18 is elevated in the horny layer in atopic dermatitis patients and associated with Staphylococcus aureus colonization, 2010 Nov 18.doi : 10.1111/j.1365-21332010

    • Author(s)
      Inoue Y, Aihara M, Kirino M, Harada I, Komori-Yamaguchi J, Yamaguchi Y, Nagashima Y, Ikezawa Z
    • Journal Title

      Br J Dermatol

      Volume: 164 Pages: 560-567

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis2010

    • Author(s)
      Ikezawa Z, Komori J, Ikezawa Y, Inoue Y, Kirino M, Katsuyama M, Aihara M
    • Journal Title

      Allergy Asthma Immunol Res

      Volume: 2 Pages: 235-246

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] セマフォリン2010

    • Author(s)
      池澤善郎
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 8 Pages: 50-51

    • Related Report
      2010 Annual Research Report
  • [Journal Article] A Role of Staphyococcus Aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis2010

    • Author(s)
      Zenro Ikezawa, Junko Komori, Yuko Ikezawa, Yusuke Inoue, Mio Kirino, Masako Katsuyama, Michiko Aihara
    • Journal Title

      Allergy, Asthma & Immunology Research online 2010(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells control a T helper 1 response in patients with Behcet's disease2010

    • Author(s)
      Yamaguchi Y, Takahashi H, Satoh T, Okazaki Y, Mizuki N, Takahashi K, Ikezawa Z, Kuwana M
    • Journal Title

      Arthritis Res Ther online 2010(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of oral allergy syndrome due to plant-derived foods with pollen sensitization in Japan2010

    • Author(s)
      Maeda N, Inomata N, Morita A, Kirino M, Ikezawa Z
    • Journal Title

      Ann Allergy Asthma Immunol 104(3)

      Pages: 205-210

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attitudes of dermatologists toward the Chapel Hill Consensus Conference nomenclature and classification2010

    • Author(s)
      Kawakami T, Takahashi K, Soma Y, Ikezawa Z
    • Journal Title

      Clin Exp Dermatol online 2010(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of wheat-dependent anaphylaxis induced by aspirin administration but not by exercise2010

    • Author(s)
      Matsukura S, Aihara M, Sugawara M, Kunimi Y, Matsuki M, Inoue Y, Kambara T, Ikezawa Z
    • Journal Title

      Clin Exp Dermatol 35(3)

      Pages: 233-237

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of both IL-27 and IFN-{gamma} after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model.2009

    • Author(s)
      Fujita H, Teng A, Nozawa R, Takamoto-Matsui Y, Katagiri-Matsumura H, Ikezawa Z, Ishii Y
    • Journal Title

      J Immunol

      Volume: 183(1) Pages: 254-260

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular cloning, expression, and characterization of a major 38-kd cochineal allergen2009

    • Author(s)
      Ohgiya Y, Arakawa F, Akiyama H, Yoshioka Y, Hayashi Y, Sakai S, Ito S, Yamakawa Y, Ohgiya S, Ikezawa Z, Teshima R.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 123(5) Pages: 1157-1162

    • Related Report
      2011 Final Research Report
  • [Journal Article] Quantitative analysis of nerve growth factor(NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis2009

    • Author(s)
      Yamaguchi J, Aihara M, Kobayashi Y, Kambara T, Ikezawa Z
    • Journal Title

      J Dermatol Sci

      Volume: 53(1) Pages: 48-54

    • NAID

      10025332027

    • Related Report
      2011 Final Research Report
  • [Journal Article] Production of both IL-27 and IFN-{gamma}after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model2009

    • Author(s)
      Fujita H, Teng A, Nozawa R, Takamoto-Matsui Y, Katagiri-Matsumura H, Ikezawa Z, Ishii Y
    • Journal Title

      J Immunol 183(1)

      Pages: 254-260

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Features of Four Cases with Cashew Nut Allergy and Cross-Reactivity between Cashew Nut and Pistachio2009

    • Author(s)
      Hasegawa M, Inomata N, Yamazaki H, Morita A, Kirino M, Ikezawa Z
    • Journal Title

      Allergol Int 58(2)

      Pages: 209-215

    • NAID

      10025109660

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, expression, and characterization of a major 38-kd cochineal allergen2009

    • Author(s)
      Ohgiya Y, Arakawa F, Akiyama H, Yoshioka Y, Hayashi Y, Sakai S, Ito S, Yamakawa Y, Ohgiya S, Ikezawa Z, Teshima R
    • Journal Title

      J Allergy Clin Immunol 123(5)

      Pages: 1157-1162

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis2009

    • Author(s)
      Yamane Y, Moriyama K, Yasuda C, Miyata S, Aihara M, Ikezawa Z, Miyazaki K
    • Journal Title

      Int Arch Allergy Immunol 150(1)

      Pages: 89-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus2009

    • Author(s)
      Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K(Pemphigus Study Group)
    • Journal Title

      J Am Acad Dermatol 60(4)

      Pages: 595-603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎の病態と治療において黄色ブドウ球菌、神経成長因子、反発性軸索ガイダンス分子Semaphorin 3Aが果たす役割2008

    • Author(s)
      池澤善郎、山口絢子、桐野実緒、松倉節子、池澤優子、蒲原毅、相原道子
    • Journal Title

      皮膚の科学

      Volume: 7 Pages: 24-32

    • NAID

      130004725528

    • Related Report
      2011 Final Research Report
  • [Journal Article] アレルギー性皮膚炎疾患の病態と治療-特に,アトピー性皮膚炎、重症薬疹、食物アレルギーに関する当教室の研究紹介を中心に-2008

    • Author(s)
      池澤善郎
    • Journal Title

      アレルギー

      Volume: 57 Pages: 968-988

    • Related Report
      2011 Final Research Report
  • [Presentation] アトピー性皮膚炎のもう一つ上のコントロールをめざして2011

    • Author(s)
      池澤善郎
    • Organizer
      第28回日本小児難治喘息・アレルギー疾患学会
    • Place of Presentation
      横浜シンポジア
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] What's new in severe drug eruptions2011

    • Author(s)
      Zenro Ikezawa, Yuko Ikezawa, Setsuko Matsukura, Michiko Aihara
    • Organizer
      What's New session on 27th, the 22^<nd> World Congress of Dermatology 2011(WCD 2011)
    • Place of Presentation
      Convention and Exhibition(COEX) Center, Seoul
    • Related Report
      2011 Final Research Report
  • [Presentation] Drug-induced urticaria and angioedema in Japan2011

    • Author(s)
      Zenro Ikezawa, Maki Moriya, Kanako Izumi, Hiroko Kunimi, Yuko Ikezawa, Setsuko Matsukura, Michiko Aihara
    • Organizer
      Symposium" Urticarial Syndromes and Angioedema" on 25th, the 22nd WCD 2011
    • Place of Presentation
      Convention and Exhibition(COEX) Center, Seoul
    • Related Report
      2011 Final Research Report
  • [Presentation] Interleukin-18 is elevated in the horny layer in patients with atopic dermatitis and is associated with Sraphylococcus aureus colonization(E-Poster Gold prize)2011

    • Author(s)
      Inoue Y, Aihara M, Kirino M, Komori-Yamaguchi J, Yamaguchi Y, Nagashima Y, Ikezawa Z
    • Organizer
      the 22nd WCD 2011
    • Place of Presentation
      Convention and Exhibition(COEX) Center, Seoul
    • Related Report
      2011 Final Research Report
  • [Presentation] Relationship between serum TARC levels and peripheral eosinophil counts or serum IgE levels in atopic dermatitis patients2011

    • Author(s)
      Kayoko Ito, Michiko Aihara, Zenro Ikezawa
    • Organizer
      the 22nd WCD 2011
    • Place of Presentation
      Convention and Exhibition(COEX) Center, Seoul
    • Related Report
      2011 Final Research Report
  • [Presentation] S3-3.職業性皮膚炎の最近の動向、シンポジウム3「職業性アレルギー疾患の最近の動向」2011

    • Author(s)
      松倉節子、池澤善郎、相原道子
    • Organizer
      第61回日本アレルギー学会秋季臨床大会
    • Place of Presentation
      グランドプリンス新高輪国際館パミール
    • Related Report
      2011 Final Research Report
  • [Presentation] MS20-1.重症アトピー性皮膚炎における低用量シクロスポリン内服療法の効果と血清IL-18変動の臨床的意義2011

    • Author(s)
      侯建全、松永朋子、相原道子、長島真由美、大川智子、井上雄介、田栗正隆、蒲原毅、森田智視、池澤善郎
    • Organizer
      第61回日本アレルギー学会秋季臨床大会
    • Place of Presentation
      グランドプリンス新高輪国際館パミール
    • Related Report
      2011 Final Research Report
  • [Presentation] O5-4.フィラグリン遺伝子変異を有する乳幼児アトピー性皮膚炎におけるスキンケア有用性の検討2011

    • Author(s)
      井上雄介、蒲原毅、中河原玲子、田中貴美代、関和男、榎本久子、野口恵美子、相原道子、池澤善郎
    • Organizer
      第61回日本アレルギー学会秋季臨床大会
    • Place of Presentation
      グランドプリンス新高輪国際館パミール
    • Related Report
      2011 Final Research Report
  • [Presentation] Intranasal administration of Semaphorin3A alleviates murine allergic rhinitis2010

    • Author(s)
      Sawaki H, Nakamura F, Aihara M, Nagashima Y, Nakazawa M, Goshima Y, Ikezawa Z
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      和歌山,和歌山県文化会館
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] アトピー性皮膚炎と痒みの病態とその治療2010

    • Author(s)
      池澤善郎
    • Organizer
      第4回関西P&Dアトピー性皮膚炎治療フォーラム
    • Place of Presentation
      大阪,ブリーゼプラザ小ホール(招待講演)
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Semaphorin3A の経鼻投与がOVA誘発性アレルギー性鼻炎に及ぼす効果の検討2010

    • Author(s)
      澤城晴名, 中村史雄, 相原道子, 長嶋洋治, 中沢正年, 小森絢子, 五嶋良郎, 池澤善郎
    • Organizer
      第20回国際痒みシンポジウム
    • Place of Presentation
      東京,東京ステーションコンファレンス6F
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Decreased expression of semaphorin3A in the lesional skin of psoriasis vulgaris with itch2010

    • Author(s)
      Kou K, Nakamura F, Aihara M, Seto K, Komori J, Kambara T, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      20th International Symposium of Itch
    • Place of Presentation
      東京,東京ステーションコンファレンス6F
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Semaphorin3Aの経鼻投与がOVA誘発性アレルギー性鼻炎に及ぼす効果の検討2010

    • Author(s)
      澤城晴名, 中村史雄, 相原道子, 長嶋洋治, 池澤善郎, 五嶋良郎
    • Organizer
      第123回薬理学会関東部会
    • Place of Presentation
      栃木,自治医科大学地域医療情報研修センター
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] アトピー性皮膚炎の痒みとその治療2010

    • Author(s)
      池澤善郎
    • Organizer
      中越皮膚科医会
    • Place of Presentation
      長岡,ホテルニューオータニ長岡(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] アトピー性皮膚炎の痒みとその対策2010

    • Author(s)
      池澤善郎
    • Organizer
      第11回大阪皮膚疾患談話会
    • Place of Presentation
      大阪,シェラトン都ホテル大阪(招待講演)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] A probable role of Staphylococcus aureus and NGF/Semaphorin 3A in pathogenesis of atopic dermatitis(AD)2010

    • Author(s)
      Ikezawa Z
    • Organizer
      Schweizerrisches Institut fur Allergie-und Asthmaforschung
    • Place of Presentation
      Davos,スイス(招待講演)
    • Year and Date
      2010-06-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intranasal administration of Semaphorin3A alleviates murine allergic rhinitis2010

    • Author(s)
      Sawaki H, Nakamura F, Nagashima Y, Aihara M, Goshima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar,ドイツ
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Interleukin-18 in horney layer of atopic dermatitis(AD) patients is associated with the severity2010

    • Author(s)
      Inoue Y, Aihara M, Harada I, Komori J, Kirino M, Nagashima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar,ドイツ
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation between Semaphorin3A expression and the itch intensity and severity in patients with psoriasis2010

    • Author(s)
      Kou K, Nakamura F, Aihara M, Seto K, Kanbara T, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar,ドイツ
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aprobable role of interleukin-18 (IL-18) in pathogenesis of atopic dermatitis (AD) from the quantitative analysis of IL-18 in horny layer of AD patients2010

    • Author(s)
      Ikezawa Z, Inoue Y, Aihara M, Harada I, Komori J, Kirino M, Nagashima Y
    • Organizer
      The 28th Symposium Collegium International Allergicum,-Translational Science-
    • Place of Presentation
      Ischia,イタリア
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intranasal administration of Semaphorin3A alleviates murine allergic rhinitis2010

    • Author(s)
      Sawaki H, Nakamura F, Aihara M, Nagashima Y, Nakazawa M, Goshima Y, Ikezawa Z
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama
    • Related Report
      2011 Final Research Report
  • [Presentation] Contribution of Th17 cell in patient with Rheumatoid Vasculitis2010

    • Author(s)
      Ikeda N, Utsumi M, Yamaguchi Y, Takahashi K, Ikezawa Z
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama
    • Related Report
      2011 Final Research Report
  • [Presentation] Decreased expression of semaphorin3A in the lesional skin of psoriasis vulgaris with itch2010

    • Author(s)
      Kou K, Nakamura F, Aihara M, Seto K, Komori J, Kambara T, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      20th International Symposium of Itch
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] A probable role of Staphylococcus aureus and NGF/Semaphorin 3A in pathogenesis of atopic dermatitis(AD)2010

    • Author(s)
      Ikezawa Z, Inoue Y, Komori J, Kou K, Sawaki H, Nagashima Y, Aihara M
    • Organizer
      Schweizerische Instituts fur Allergie-uns Asthma forschung(SIAF) Seminar
    • Place of Presentation
      Davos(Schweiz)
    • Related Report
      2011 Final Research Report
  • [Presentation] Intranasal administration of Semaphorin3A alleviates murine allergic rhinitis2010

    • Author(s)
      Sawaki H, Nakamura F, Nagashima Y, Aihara M, Goshima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar(Germany)
    • Related Report
      2011 Final Research Report
  • [Presentation] Interleukin-18 in horney layer of atopic dermatitis(AD) patients is associated with the severity2010

    • Author(s)
      Inoue Y, Aihara M, Harada I, Komori J, Kirino M, Nagashima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar(Germany)
    • Related Report
      2011 Final Research Report
  • [Presentation] Prevalence and clinical characteristics of autoantibody profile in Japanise patients with dermatomyositis2010

    • Author(s)
      Ikeda N, Inasaka M, Yamaguchi Y, Takahashi K, Kuwana M, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar(Germany)
    • Related Report
      2011 Final Research Report
  • [Presentation] Correlation between Semaphorin3A expression snd the itch intensity and severity in patients with psoriasis2010

    • Author(s)
      Kou K, Nakamura F, Aihara M, Seto K, Kanbara T, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar(Germany)
    • Related Report
      2011 Final Research Report
  • [Presentation] A case of anaphylaxis caused by soybean sprout2010

    • Author(s)
      Nakagawara R, Kohno M, Matsukura S, Imai M, Kanbara T, Miura Y, Itagaki Y, Ikezawa Z
    • Organizer
      9th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Weimar(Germany)
    • Related Report
      2011 Final Research Report
  • [Presentation] A probable role of interleukin-18(IL-18) in pathogenesis of atopic dermatitis(AD) from the quantitative analysis of IL-18 in horny layer of AD patients2010

    • Author(s)
      Ikezawa Z, Inoue Y, Aihara M, Harada I, Komori J, Kirino M, Nagashima Y
    • Organizer
      The 28th Symposium Collegium International Allergicum(CIA) Translational Science
    • Place of Presentation
      Ischia(Italy)
    • Related Report
      2011 Final Research Report
  • [Presentation] TBT affects on Peyer's patches to reduce the number of cells and ability of IL-10 production and inhibit the induction of oral tolerance2010

    • Author(s)
      Uchida T, Nakazawa M, Minami M, Ikezawa Z
    • Organizer
      28th Symposium Collegium International Allergicum Translational Science
    • Place of Presentation
      Ischia(Italy)
    • Related Report
      2011 Final Research Report
  • [Presentation] 重症薬疹におけるステロイドパルス療法(シンポジウム)2009

    • Author(s)
      池澤優子, 相原道子, 松倉節子, 山根裕美子, 蒲原毅, 池澤善郎
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Occupational contact urticaria syndrome caused by handling lettuce and chicory : cross-reactivity between lettuce and chicory2009

    • Author(s)
      Morita A, Inomata N, Kondou M, Shirai T, Itagaki Y, Ikezawa Z
    • Organizer
      The 17th International Contact Dermatitis Symposium, The 10th Asia-Pacific Environmental and Occupational Dermatology Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical analysis of patients with metal allergy2009

    • Author(s)
      Shinoda J, Aihara M, Okamura Y, Kirino M, Takahashi S, Watanabe C, Takahashi K, Ikezawa Z
    • Organizer
      The 17th International Contact Dermatitis Symposium, The 10th Asia-Pacific Environmental and Occupational Dermatology Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 重症薬疹(SJS, TEN)におけるサイトカインの経時的変化-血漿交換およびステロイドパルス療法の効果の検討2009

    • Author(s)
      松倉節子, 相原道子, 池澤優子, 相原雄幸, 大山孝宣, 蒲原毅, 池澤善郎, 高橋幸利
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 地域の乳幼児アトピー性皮膚炎は, 本当は増えているのか?減っているのか?(第2報)2009

    • Author(s)
      田中良知, 蒲原毅, 井上雄介, 立脇聡子, 中村和子, 田中貴美代, 池澤善郎
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] アトピー性皮膚炎患者における皮膚角層内IL-18と皮表黄色ブドウ球菌の測定による病態の解析2009

    • Author(s)
      井上雄介, 相原道子, 原田郁代, 小森絢子, 桐野実緒, 池澤善郎
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Decreased expression of semaphorin3A in the lesional skin of psoriasis with itch2009

    • Author(s)
      Kou K, Nakamura F, Aihara M, Kanbara T, Chin K, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      5th international workshop for the study of itch
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] TENのアフェレーシス治療-皮膚科から・救急集中治療から-中毒性表皮壊死症における血漿交換-当科の症例とその適応について2009

    • Author(s)
      蒲原毅, 相原道子, 池澤優子, 松倉節子, 大山孝宣, 相原雄幸, 平和伸仁, 高橋幸利, 池澤善郎
    • Organizer
      第30回日本アフェレーシス学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] アトピー性皮膚炎における黄色ブドウ球菌の役割2009

    • Author(s)
      相原道子, 井上雄介, 池澤善郎
    • Organizer
      第33回日本小児皮膚科学会学術大会, シンポジウム
    • Place of Presentation
      幕張
    • Year and Date
      2009-07-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発症・悪化因子としてのバリアー機能異常とその対策2009

    • Author(s)
      池澤善郎, 井上雄介, 蒲原毅
    • Organizer
      第33回日本小児皮膚科学会学術大会, シンポジウム
    • Place of Presentation
      幕張
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳幼児期アトピー性皮膚炎の有症率に関する研究(第5報)2009

    • Author(s)
      蒲原毅, 中村和子, 田中良知, 井上雄介, 田中貴美代, 池澤善郎
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Antipholipid syndrome may induce arteritis as against conventional theory2009

    • Author(s)
      Ikeda N, Utsumi M, Uchida T, Onoda M, Takahashi K, Ikezawa Z
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Quantitative analysis of interleukin-18 in horny lazer of atopic dermatitis patients in association with Staphylococcus aures colonization2009

    • Author(s)
      Inoue Y, Aihara M, Harada I, Komori J, Kirino M, Nagashima Y, Ikezawa Z
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Recent trends in food allergy(Symposium)2009

    • Author(s)
      Ikezawa Z
    • Organizer
      The 17th International Contact Dermatitis Symposium, The 10th Asia-Pacific Environmental and Occupational Dermatology Symposium
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Decreased expression of semaphorin3A in the lesional skin of psoriasis with itch2009

    • Author(s)
      Kou K, Nakamura F, Aihara M, Kanbara T, Chin K, Nagashima Y, Goshima Y, Ikezawa Z
    • Organizer
      5th International Workshop for the Study of Itch(IWSI)
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Book] WHAT'S NEW in皮膚科学2010-2011(宮地良樹編)、セマフォリンとかゆみの接点2010

    • Author(s)
      池澤善郎
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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