Role of platelet in regulation of cutaneous inflammation
| Project/Area Number |
21591472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KATOH Norito 京都府立医科大学, 医学研究科, 教授 (30244578)
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| Co-Investigator(Kenkyū-buntansha) |
ASAI Jun 京都府立医科大学, 医学研究科, 助教 (50438222)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 皮膚炎症 / 再生学 / 血小板 / 接触過敏反応 / 炎症の収束 / 樹状細胞 / 白血球遊走 / リンパ管 / アトピー性皮膚炎 / CD11b+Gr-1+細胞 / 可視化 |
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| Research Abstract |
1) Role of platelets in contact hypersensitivity reaction : Mice were sensitized and elicited in ears with hapten, with or without platelet depletion, by administering antiplatelet antibody or busulfan. In vivo imaging demonstrated that platelets were activated, formed complex with leukocytes and engulfed into the cytoplasm of the leukocytes in the capillary within 2 hours after elicitation. We showed that platelets play important role in migration of CD11r+Gr-1+leukocytes which regulated inflammatory reaction in cutaneous tissue.
2) We showed that platelets play important roles in redistribution of dendritic cells including epidermal Langerhans cells which may have regulatory function in sensitization to the skin tissue.
Taken together, we show that platelets have regulatory roles in cutaneous inflammation by helping migration of cells with regulatory function.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice2012
Author(s)
Nishimura Y, Ii M, Qin, G, Hamada H, Asai J, Takenaka H, Sekiguchi H, Renault MA, Jujo, K, Katoh N, Kishimoto S, Ito A, Kamide C, Kenny J, Millay M, Misener S, Thorne T, Losordo DW
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Journal Title
J Invest Dermatol
Volume: 132
Pages: 711-720
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[Journal Article] The role of IL-33 in chronic allergic conjunctivitis2009
Author(s)
Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 50
Pages: 4646-52
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[Journal Article] The role of IL-33 in chronic allergic conjunctivitis.2009
Author(s)
Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S.
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Journal Title
Invest Ophthalmol Vis Sci 50
Pages: 4646-4652
Related Report
Peer Reviewed
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