| Project/Area Number |
21591477
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IZUMI Takeshi 北海道大学, 大学院・医学研究科, 助教 (60312360)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Takayuki 北海道大学, 大学院・医学研究科, 助教 (60374229)
YOSHIOKA Mitsuhiro 北海道大学, 大学院・医学研究科, 教授 (40182729)
YAMAGUCHI Taku 長崎国際大学, 薬学部, 准教授 (80325563)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 精神薬理学 / 不安 |
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| Research Abstract |
(1) We indicated that both excitatory output from the basolateral nucleus of amygdala (BLA) and inhibitory output from the intercalated nucleus of amygdala (ITC) dually regulated the central nucleus of amygdala (CeA) which performed the final output of anxiety response from the amygdala, using conditioned fear in rats, an animal model of anxiety.(2)We indicated that the infralimbic cortex (IL) regulates impulsivity, using 3 choice serial reaction time task, an animal model of impulsivity. Noradrenalin increase in the brain inhibited impulsivity, whereas stimulation of α4β2 nicotinic acetylcholine receptors in IL enhanced impulsivity.
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