| Project/Area Number |
21591484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 精神生理学 / 社会的ストレス / GABA作動性神経 / 内側前頭前皮質 / 母子分離 / 社会的隔離 / 神経修飾因子 / カルシウム結合タンパク / 社会的行動 / GABA作動性神経系 / 前頭前皮質 / 扁桃体 / モノアミン系神経修飾因子 |
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| Research Abstract |
To test the hypothesis that social stress of neonatal maternal deprivation followed by social isolation affects social behavior-relevant physiological functions of specific subclasses of GABAergic interneurons in the limbic structures, early stress-related changes in the expression levels of calcium binding proteins, social behaviors and the activity of spontaneous inhibitory postsynaptic currents (sIPSCs) were investigated for Wistar rats. Early social stress was found to elevate the expression levels of parvalbumin (PV) in basolateral amygdala and II /III layers of medial prefrontal cortex, whereas those of calretinin (CR) and calbindin (CB) showed no changes in the limbic structures. Ano-genital sniffing behavior, one test for social interaction test, tended to increase in the neonatally stressed animals. Electrophysiological measurements of GABAergic interneurons assessed by the mean amplitude and the frequency of sIPSCs recorded from principal neurons in the limbic regions, however, did not show any difference between the stressed group and control non-stressed group. These results suggest that early social stress produces altered social behavior via mechanisms other than those involving GABAergic interneurons
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