| Project/Area Number |
21591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Ryuichiro 宮崎大学, 医学部, 助教 (90336298)
ABE Hiroshi 宮崎大学, 医学部, 講師 (20344848)
NONAKA Hiroi 宮崎大学, 医学部, 助教 (30311591)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMORI Toshikazu 宮崎大学, 医学部, 教授 (20112211)
EBIHARA Kosuke 宮崎大学, 医学部, 助教 (20510720)
MATSUO Hisae 宮崎大学, 医学部, 助教 (70511476)
UEDA Yuto 宮崎大学, 医学部, 准教授 (70244192)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | パーキンソン病 / L-DOPA / 神経移植 / 転写調節因子 / 神経科学 |
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| Research Abstract |
A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene(IEG) proteins(FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine(6-OHDA) rat model of Parkinson's disease. During a course of chronic L-DOPA treatment, rats with a 6-OHDA lesion developed abnormal involuntary movements. Compared with the rats in the acute L-DOPA treatment group, those in the chronic treatment group had significantly more FosB-immunopositive cells in the anterior cingulate(Cg) and the dorsolateral caudate-putamen ipsilateral to the lesion. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.
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