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Kicking and biting behavioral responses toward mechanical touch stimuli in stress-disorder model mouse

Research Project

Project/Area Number 21591487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKagoshima University

Principal Investigator

KUCHIIWA Satoshi  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (90161637)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsうつ病 / 統合失調症 / 行動学研究 / 接触逃避行動 / 蹴り払い応答 / 対物攻撃行動 / 噛みつき応答 / イリタビリティ / 接触刺激応答計測システム(TRM) / 接触刺激逃避行動 / 蹴り払い応答反応 / 噛みつき応答反応 / 易怒性irritability / 鬱病モデルマウス / 統合失調症モデルマウス / 接触刺激応答行動 / 蹴飛ばし行動 / 噛みつき行動 / ストレス障害モデル / 欝病モデル / 統合失調症モデル / 隔離飼育動物 / 行動学実験 / 蹴り行動 / 噛み行動 / うつ病モデル / ストレス症状 / 行動学的定量評価
Research Abstract

Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010 2009 Other

All Journal Article (2 results) Presentation (10 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 蹴り払い応答と噛みつき応答を指標とする易刺激性の行動学的評価-慢性緩和ストレスマウスを用いた行動学的・行動薬理学的研究-2012

    • Author(s)
      口岩俊子、若本純子、村上理、口岩聡
    • Journal Title

      鹿児島純心女子大学大学院人間科学研究科紀要

      Volume: 第7号

    • NAID

      120005566914

    • Related Report
      2011 Final Research Report
  • [Journal Article] 蹴り払い応答と噛みつき応答を指標とする易刺激性の行動学的評価-慢性緩和ストレスマウスを用いた行動学的・行動薬理学的研究-2012

    • Author(s)
      口岩俊子
    • Journal Title

      鹿児島純心女子大学大学院人間科学研究科紀要

      Volume: 7(印刷中)

    • NAID

      120005566914

    • Related Report
      2011 Annual Research Report
  • [Presentation] Measurements of kicking and biting responses toward touch stimuli for evaluation of irritability in isolation-reared mice2012

    • Author(s)
      Toshiko Kuchiiwa, Osamu Murakami, Satoshi Kuchiiwa
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都市
    • Related Report
      2011 Final Research Report
  • [Presentation] Measurements of kicking and biting responses toward touch stimuli for evaluation of irritability in isolation-reared mice2012

    • Author(s)
      T.Kuchiiwa, O.Murakami, S.Kuchiiwa
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都市、国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] Kicking and biting responses toward mechanical touch stimuli for evaluation of aggravation and amelioration of stress disorder2011

    • Author(s)
      Toshiko Kuchiiwa, Satoshi Kuchiiwa, Osamu Murakami
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] 「蹴飛ばし行動」と「噛みつき行動」を指標とするストレス障害の悪化と治癒の定量的行動評価法2011

    • Author(s)
      口岩俊子、口岩聡、村上理、口岩琢哉、若本純子
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Final Research Report
  • [Presentation] Kicking and biting responses toward mechanical touch stimuli for evaluation of aggravation and amelioration of stress disorder2011

    • Author(s)
      T.Kuchiiwa, S.Kuchiiwa, O.Murakami
    • Organizer
      Neruo 20110(第34回日本神経化学大会)
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「蹴飛ばし行動」と「噛みつき行動」を用いたストレス障害と治癒の定量的行動評価法2011

    • Author(s)
      口岩俊子、口岩聡, 他
    • Organizer
      第84回 日本薬理学会年会
    • Place of Presentation
      横浜市(東日本大震災のため誌上発表に変更)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantitative analysis of kicking and biting behavioral responses to mechanical touch stimuli in socially isolated mice2010

    • Author(s)
      Toshiko Kuchiiwa, Takatoshi Komiya, Takuya Kuchiiwa, Junko Wakamoto1, Osamu Murakami, Satoshi Kuchiiwa
    • Organizer
      第33回日本神経科学学会大会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Final Research Report
  • [Presentation] Quantitative analysis of kicking and biting responses to mechanical touch stimuli in socially isolated mice2010

    • Author(s)
      T.Kuchiiwa, T.Komiya, et al.
    • Organizer
      第34回 日本神経科学大会 Neuro2010
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] ストレス行動評価、HPLC法による脳内モノアミン定量およびc-Fos免疫染色による統合失調症モデルマウスの解析2009

    • Author(s)
      小宮孝俊, 他
    • Organizer
      第26回 日本薬学会九州支部大会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス行動評価、HPLC法による脳内モノアミン定量およびc-Fos免疫染色による統合失調症モデルマウスの解析2009

    • Author(s)
      小宮孝俊、アブドアイニアブドラヒマン、口岩俊子、村上理、武田泰生、口岩聡、山田勝士
    • Organizer
      第26回日本薬学会九州支部大会
    • Place of Presentation
      福岡市
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ等(科学研究費助成の公開ページ)

    • URL

      http://www.kuchiiwa.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kuchiiwa.jp

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳神経細胞への薬物の標的化剤2012

    • Inventor(s)
      口岩聡、口岩俊子
    • Industrial Property Rights Holder
      鹿児島大学
    • Acquisition Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 機械応答計測システムおよび刺激応答計測方法2011

    • Inventor(s)
      口岩聡、口岩俊子、村上理
    • Industrial Property Rights Holder
      鹿児島大学
    • Acquisition Date
      2011-11-11
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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