| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.
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