Early diagnosis of Alzheimer's disease by amyloid PET and MRI

• Project/Area Number: 21591499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tohoku University
• Principal Investigator: WARAGAI Masaaki 東北大学, 加齢医学研究所, 非常勤講師 (50533775)
• Co-Investigator(Kenkyū-buntansha): ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613) ; TOMITA Naoki 東北大学, 病院, 助教 (00552796)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アルツハイマー病 / 軽度認知障害 / アミロイドPET / BF-227 / 構造的MRI / 簡易バイオーマーカー / 発症前アルツハイマー病 / 血漿中Aβ40/42比率 / 血漿中アクロレイン / アルツハイマー病発症前診断 / 軽度認知障害(MCI) / 早期診断 / 予後予測 / アミロイド-PET / FDG-PET / MRI

Research Abstract

We studied subjects with non-demented controls, mild cognitive impairment(MCI)and early Alzheimer's disease using BF-227 PET and structural MRI. We found that BF-227 PET is useful for early diagnosis of MCI. We found that BF-227 PET is useful for early diagnosis for AD and structural MRI is suitable for tracking of disease progression of the disease. Amyloid deposition was not correlated with grey matter atrophy.

Research Products

• [Journal Article] Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H β-synuclein (2012)
  • Author(s): Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Sugama S, Hashimoto M
  • Journal Title: Neurosci Lett Volume: (2012 Mar 21.[Epub ahead of print])(未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Bridging molecular genetics and biomarkers in lewy body and related disorders (2011)
  • Author(s): Ho GJ, Liang W, Waragai M, Sekiyama K, Masliah E, Hashimoto M
  • Journal Title: Int J Alzheimers Dis Volume: 842475 Issue: 1
  • DOI: 10.4061/2011/842475
  • Peer Reviewed
• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparison to FDG-PET (2010)
  • Author(s): Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, KudoY, Arai H.
  • Journal Title: J Neurol Volume: 257 Pages: 721-727
  • Peer Reviewed
• [Journal Article] Pathobiology of Alzheimer's disease and biomarker development (2010)
  • Author(s): Arai H, Okamura N, Waragai M, Furukawa K, Yanai K, Kudo Y
  • Journal Title: Nihon Yakurigaku Zasshi Volume: 135 Pages: 3-7
  • NAID: 10026543897
  • Peer Reviewed
• [Journal Article] α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson's Disease (2010)
  • Author(s): Waragai M, Sekiyama K, Sekigawa A, Takamatsu Y, Fujita M, Hashimoto M
  • Journal Title: Int J Mol Sci Volume: 11(11) Pages: 4257-66
  • Peer Reviewed
• [Journal Article] A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain (2010)
  • Author(s): Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M
  • Journal Title: Nat Commun Volume: Nov 2 Pages: 1-110
  • Peer Reviewed
• [Journal Article] P2X7 receptor signaling pathway as a therapeutic targetfor neurodegenerative diseases (2010)
  • Author(s): Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, IwamaruY, Kitani H, Hashimoto M
  • Journal Title: Arch Immunol Ther Exp (Warsz) Volume: 58(2) Pages: 91-6
  • Peer Reviewed
• [Journal Article] アルツハイマー病の病態とバイオマーカー開発 (2010)
  • Author(s): 荒井啓行、岡村信行、藁谷正明、古川勝敏、谷内一彦、工藤幸司
  • Journal Title: 日薬理誌 135 Pages: 3-7
  • NAID: 10026543897
• [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease (2009)
  • Author(s): Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H
  • Journal Title: J Neurol Sci Volume: 285 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Gangliosides' protection against lysosomal pathology of synucleinopathies. (2009)
  • Author(s): Wei J, Fujita M, Sekigawa A, Sekiyama K, Waragai M, Hashimoto M
  • Journal Title: Autophagy Volume: 5(6) Pages: 860-1
  • Peer Reviewed
• [Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies (2009)
  • Author(s): Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
  • Journal Title: Am J Pathol Volume: 174(5) Pages: 1891-909
  • Peer Reviewed
• [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease. (2009)
  • Author(s): Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H.
  • Journal Title: J Neurol Sci 285 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparison to FDG-PET. (2009)
  • Author(s): Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
  • Journal Title: J Neurol
  • Peer Reviewed
• [Presentation] A study of correlation between the Mini Mental State Examination (MMSE) score, the grey matter atrophy and potentially Alzheimer's disease related plasma biomarkers (2011)
  • Author(s): Masaaki Waragai, Madoka Yoshida, Ryotaro Saiki, Mutsumi Mizoi, Norihiro Ogawa, Hiroyasu Akatsu, Jun Tashiro, Nobuyuki Okamura, Hirowki Arai, Takeshi Yamamoto, Naomichi Iwai, Kenichi Uemura, Kazuei Igarashi
  • Organizer: Alzheimer's Association International Conference 2011 (AAIC)
  • Place of Presentation: パリ、フランス
  • Year and Date: 2011-07-17
• [Presentation] Amyloid PET in mild cognitive impairment and Alzheimer's disease with [11C] BF-227 : comparison to voxel-based morphometric MRI (2010)
  • Author(s): Waragai M, et al.
  • Organizer: Alzheimer's Association International Conference 2010 (AAIC)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] A study of correlation between the Mini Mental State Examination (MMSE)score, thegrey matter atrophy andpotentially Alzheimer's disease related plasma biomarkers (2010)
  • Author(s): Waragai M, et al.
  • Organizer: Alzheimer's Association International Conference 2010 (AAIC)
  • Place of Presentation: Paris, France
  • Year and Date: 2010-07-11
• [Presentation] P1-377 Amyloid PET in mild cognitive impairment and Alzheimer's disease with [^<11>C] BF-227 : comparison to voxel-based morphometric MRI (2010)
  • Author(s): Masaaki Waraeai, Nobuyuki Okamura, Katsutoshi Furukawa, He Shao, Manabu Tashiro、Shozo Furumoto, Kentaro Sugi, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai
  • Organizer: International Conference on Alzheimer's Disease (ICAD) 2010
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] P1-390 PET amyloid imaging in mild cognitive impairment and Alzheimer's disease using novel amyloid ligand[f] FACT : The hydroxylatedf BF-227 derivative (2010)
  • Author(s): He Shao, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Masaaki Waragai, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai
  • Organizer: International Conference on Alzheimer's Disease (ICAD) 2010
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-11
• [Presentation] IC-P-054 PET with neta-amyloid tracer 11C-BF-227 in MCI and Alzheimer's disease : comparison to biofluid biomarkers (2010)
  • Author(s): Katsutashi Furukawa, Nobuyuki Okamura, Manabu Tashira, Masaaki Waraeai, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai
  • Organizer: International Conference on Alzheimer's Disease (ICAD) 2010
  • Place of Presentation: Honolulu、Hawaii
  • Year and Date: 2010-07-11
• [Presentation] アルツハイマー病早期診断における[^<11>C]BF227-PETと、MRI-voxel-based morphometry(MRI-VBM)の有用性の比較検討 (2009)
  • Author(s): 藁谷正明, 岡村信行, 古川勝敏, 谷内一彦, 工藤幸司, 荒井啓行
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-02
• [Book] 石灰沈着を伴うびまん性神経原線維変化病 (2011)
  • Author(s): 藁谷正明
  • Publisher: 日本臨牀社
• [Book] 日本臨床69巻増刊号10 (2011)
  • Author(s): 藁谷正明
  • Publisher: 日本臨床社