Early diagnosis of Alzheimer's disease by amyloid PET and MRI
| Project/Area Number |
21591499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
WARAGAI Masaaki 東北大学, 加齢医学研究所, 非常勤講師 (50533775)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613)
TOMITA Naoki 東北大学, 病院, 助教 (00552796)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アルツハイマー病 / 軽度認知障害 / アミロイドPET / BF-227 / 構造的MRI / 簡易バイオーマーカー / 発症前アルツハイマー病 / 血漿中Aβ40/42比率 / 血漿中アクロレイン / アルツハイマー病発症前診断 / 軽度認知障害(MCI) / 早期診断 / 予後予測 / アミロイド-PET / FDG-PET / MRI |
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| Research Abstract |
We studied subjects with non-demented controls, mild cognitive impairment(MCI)and early Alzheimer's disease using BF-227 PET and structural MRI. We found that BF-227 PET is useful for early diagnosis of MCI. We found that BF-227 PET is useful for early diagnosis for AD and structural MRI is suitable for tracking of disease progression of the disease. Amyloid deposition was not correlated with grey matter atrophy.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain2010
Author(s)
Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M
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Journal Title
Nat Commun
Volume: Nov 2
Pages: 1-110
Related Report
Peer Reviewed
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[Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease2009
Author(s)
Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H
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Journal Title
J Neurol Sci
Volume: 285
Pages: 100-108
Related Report
Peer Reviewed
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[Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.2009
Author(s)
Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H.
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Journal Title
J Neurol Sci 285
Pages: 100-108
Related Report
Peer Reviewed
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[Presentation] A study of correlation between the Mini Mental State Examination (MMSE) score, the grey matter atrophy and potentially Alzheimer's disease related plasma biomarkers2011
Author(s)
Masaaki Waragai, Madoka Yoshida, Ryotaro Saiki, Mutsumi Mizoi, Norihiro Ogawa, Hiroyasu Akatsu, Jun Tashiro, Nobuyuki Okamura, Hirowki Arai, Takeshi Yamamoto, Naomichi Iwai, Kenichi Uemura, Kazuei Igarashi
Organizer
Alzheimer's Association International Conference 2011 (AAIC)
Place of Presentation
パリ、フランス
Year and Date
2011-07-17
Related Report
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