Realization of near-infrared spectroscopy (NIRS) as a clinical examination for suicide risk in mood disorders.

• Project/Area Number: 21591503
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: KAMEYAMA Masaki 群馬大学, 大学院・医学系研究科, 助教 (00455982)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Masato 群馬大学, 大学院・医学系研究科, 准教授 (20221533) ; TAKAHASHI Keisuke 群馬大学, 医学部, 助教 (20455984) ; 結城 直也 群馬大学, 大学院・医学系研究科, 助教 (20420193)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 自殺 / 気分障害 / NIRS / 脳機能 / うつ病 / 脳画像

Research Abstract

Brain substrates of suicidal symptoms in mood disorders were investigated using near-infrared spectroscopy (NIRS). The oxy-hemoglobin changes in cognitive task correlated the score of suicidal idea in mood disorders. These results suggest prefrontal cortex as brain substrates of suicidal symptoms in mood disorders. If these findings are confirmed, NIRS data can be employed as a clinically useful biological marker for the assessment of suicidal risk in mood disorders.

Research Products

• [Journal Article] 脳画像からみた双極性障害の特徴-多チャンネルNIRSによる検討を中心に (2010)
  • Author(s): 亀山正樹, 青山義之, 須田真史, 武井雄一, 成田耕介, 間島竹彦, 福田正人, 三國雅彦
  • Journal Title: 臨床精神薬理 Volume: 13 Pages: 1499-1508
• [Journal Article] 多チャンネルNIRSを用いた統合失調症の局所脳血流変化 (2009)
  • Author(s): 亀山正樹, 福田正人, 青山義之, 山岸裕, 須田真史, 武井雄一, 成田耕介, 三國雅彦
  • Journal Title: 脳と精神の医学 Volume: 20 Pages: 75-81
• [Journal Article] Subjective feeling of psychological fatigue is related to decreased reactivity in ventrolateral prefrontal cortex. (2009)
  • Author(s): Suda M, Fukuda M, Sato T, Iwata S, Song M, Kameyama M, Mikuni M
  • Journal Title: Brain Re 1252 Pages: 152-160
  • Peer Reviewed
• [Journal Article] 多チャンネルNIRSを用いた統合失調症の局所脳血流変化 (2009)
  • Author(s): 亀山正樹, 福田正人, 青山義之, 山岸裕, 須田真史, 武井雄一, 成田耕介, 三國雅彦
  • Journal Title: 脳と精神の医学 20 Pages: 75-81
• [Journal Article] Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling : a voxel-based morphometric study.
  • Author(s): Narita K, Suda M, Takei Y, Aoyama Y, Majima T, Kameyama M, Kosaka H, Amanuma M, Fukuda M, Mikuni M
  • Journal Title: Prog Neuro-Psychopharmacol Biol Psychiatry. Volume: in press
  • Peer Reviewed
• [Journal Article] Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex : a near-infrared spectroscopy study.
  • Author(s): Suda M, Toru U, Fukuda M, Sato T, Kameyama M, Mikuni M
  • Journal Title: J.Psychiatr Res (In press)
  • Peer Reviewed
• [Presentation] 光トポグラフィー検査(NIRS)から見たうつ病 (2011)
  • Author(s): 福田正人, 武井雄一, 須田真史, 青山義之, 桜井敬子, 石毛陽子, 亀山正樹, 成田耕介, 三國雅彦, 上原徹
  • Organizer: 第8回日本うつ病学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-11
• [Presentation] Near-infrared spectroscopy in psychiatry (Symposium 2 : Use of near-infrared spectroscopy (NIRS)) (2010)
  • Author(s): Fukuda M, Suda M, Takei Y, Aoyama Y, Sato T, Sakurai N, Narita K, Kameyama M, Uehara T, Mikuni M
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
• [Presentation] Near-infrared spectroscopy in psychiatry (Symposium 2: Use of near-infrared spectroscopy(NIRS)) (2010)
  • Author(s): Fukuda M, Suda M, Takei Y, Aoyama Y, Sato T, Sakurai N, narita K, kameyama M, Uehara T, Mikuni M
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
• [Presentation] Near-infrared spectroscopy in mood disorders (2009)
  • Author(s): Fukuda M, Suda M, Aoyama Y, Takei Y, Sato T, Kameyama M, Narita K, Uehara T, Mikuni M
  • Organizer: The 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris
• [Presentation] Near-infrared spectroscopy in mood disorders (2009)
  • Author(s): Fukuda M, Suda M, Aoyama Y, Takei Y, Sato T, kameyama M, Narita K, Uehara T, Mikuni M
  • Organizer: The 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France
• [Book] NIRSによる精神疾患の診断.神庭重信・加藤忠史編『脳科学エッセンシャル-精神疾患の生物学的理解のために』(専門医のための精神科臨床リュミエール16) (2010)
  • Author(s): 福田正人, 亀山正樹
  • Publisher: 中山書店
• [Book] 精神科専門医のためのプラクティカル精神医学 (2009)
  • Author(s): 福田正人, 亀山正樹
  • Publisher: 中山書店