Is there any common pathogenesis between autism spectrum disorder and bipolar disorder
| Project/Area Number |
21591509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
MUNESUE Toshio 金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Mitsuru 金沢大学, 子どものこころの発達研究センター, 特任准教授 (00377384)
KOSAKA Hirotaka 福井大学, 医学部子どもの発達研究センター, 特命准教授 (70401966)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 自閉症スペクトラム障害 / 双極性障害 / ロールシャッハ・テスト / 脳形態画像 / 核磁気共鳴画像 / 拡散テンソル画像 / 強迫症状 / Magnetic resonance imaging / Rorschach test |
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| Research Abstract |
Rorschach ink blot reactions were examined among 39 subjects with autism spectrum disorder(ASD), 41 subjects with bipolar disorder(BD) and 52 healthy individuals, aged 15 to 29 year, respectively. The score of the valuables designated as' pure F%' and' FM' was significantly different in both the subjects with ASD and the subjects with BD compared to healthy individuals. The score of both valuables significantly correlated with the Autism-spectrum Quotient. Also, fractional anisotropy(FA) values were investigated preliminarily among these three groups using diffusion tensor imaging method. While FA value in the splenium of corpus callosum was significantly lower in subjects with BD than in subjects with ASD and healthy subjects, FA value was the lowest in subjects with ASD and comorbid BD.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Language performance and auditory evoked fields in 2-to 5-year-old children2012
Author(s)
Yoshimura, Y., Kikuchi, M., Shitamichi, K., Ueno, S., Remijn, G. B., Haruta, Y., Oi, M., Munesue, T., Tsubokawa, T., Higasida, H., Minabe, Y.
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Journal Title
Eur. J. Neurosci
Volume: 35
Pages: 644-650
Related Report
Peer Reviewed
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[Journal Article] Social memory, amnesia, and autism : brain oxytocin secretion is regulated by NAD+and single nucleotide polymorphism of CD382012
Author(s)
Higashida, H., Yokoyama, S., Huang, J.-J., Liu, L., Ma, W.-J., Akter, S., Higashida, C., Kikuchi, M., Minabe, Y., Munesue, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders : an fMRI study2012
Author(s)
Morita, T., Kosaka, H., Saito, D. N., Ishitobi, M., Munesue, T., Itakura, S., Omori, M., Okazawa, H., Wada, Y., Sadato, N.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Lateralized theta wave connectivity and language performance in 2-to 5-year-oldchildren2011
Author(s)
Kikuchi, M., Shitamichi, K., Yoshimura, Y., Ueno, S., Remijn, G. B., Hirosawa, T., Munesue, T., Tsubokawa, T., Haruta, Y., Oi, M., Higashida, H., Minabe, Y.
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Journal Title
J. Neurosci
Volume: 31
Pages: 14984-14988
Related Report
Peer Reviewed
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[Presentation] Oxytocin effect in young males with autism spectrum disorders : Aneye-tracking study2011
Author(s)
Kosaka, H., Munesue, T., Saito, D. N., Fujii, T., Yanaka, H., Ishitobi, M., Asano, M., Narita, K., Murata, T., Omori, M., Okazawa, H., Sadato, N., Wada, Y.
Organizer
Joint Academic Conference on Autism Spectrum Disorders
Place of Presentation
日本財団ビル(東京都)
Year and Date
2011-12-02
Related Report
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