Assessment of central nervous system function through autonomic nervous system in Alzheimer's disease

• Project/Area Number: 21591510
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: UMEGAKI Hiroyuki 名古屋大学, 医学部附属病院, 助教 (40345898)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Yusuke 名古屋大学, 大学院・医学系研究科, 講師 (90378167)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 認知症 / 老化 / ストレス / アルツハイマー型認知症 / 心拍変動 / コリン作動性神経 / 海馬 / 神経心理検査 / 痴呆

Research Abstract

In animal experiment the acute administration of cholinesterase inhibitor(ChEI) activated the sympathetic nervous system, while the chronic administration affected the parasympathetic nervous system.
In the clinical study, we found the negative correlation between depressive mood and the activity of sympathetic nervous system in AD subjects.

Research Products

• [Journal Article] Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice. (2011)
  • Author(s): Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A.
  • Journal Title: Neuropathology Volume: 31(1) Pages: 20-28
  • Peer Reviewed
• [Journal Article] Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. (2011)
  • Author(s): Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A.
  • Journal Title: Brain Behav Immun Volume: 25(1) Pages: 83-100
  • Peer Reviewed
• [Journal Article] Pathophysiology of cognitive dysfunction in older people with type 2 diabetes : vascular changes or neurodegeneration? (2010)
  • Author(s): Umegaki H
  • Journal Title: Age and Ageing Volume: 39(1) Pages: 8-10
  • Peer Reviewed
• [Journal Article] Effects of educational background on verbal fluency task performance in older adults with Aizheimer's disease and mild cognitive impairment. (2010)
  • Author(s): Kawano N, Umegaki H, Suzuki Y, Yamamoto S, Mogi N, Iguchi A.
  • Journal Title: International Psychogeriatrics Volume: 22(6) Pages: 995-1002
  • Peer Reviewed
• [Journal Article] Responses of Hypothalamo-Pituitary-Adrenal Axis to a Cholinesterase Inhibitor (2009)
  • Author(s): Umegaki H, Yamamoto A, Suzuki Y, Iguchi A.
  • Journal Title: Neuroreport Volume: 20(15) Pages: 1366-70
  • Peer Reviewed
• [Journal Article] Different contribution of the lateral bednucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucose and adre no corticotropic hormone in free moving rats (2009)
  • Author(s): Zhu W, Cui J, Zhang R, Umegaki H.
  • Journal Title: Neuroendocrinology Letter Volume: 30(4) Pages: 511-4
  • Peer Reviewed
• [Journal Article] Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhi bitor (2009)
  • Author(s): Umegaki H, Yamamoto A, Suzuki Y, Iguchi A
  • Journal Title: Neuroreport 20(15) Pages: 1366-1370
  • Peer Reviewed
• [Presentation] 認知症患者における心拍変動解析による自律神経機能評価:うつ傾向にあるアルツハイマー型認知症およびamnestic MCI患者と自律神経機能障害についての考察 (2011)
  • Author(s): 野々垣禅、牧野多恵子、鈴木裕介、河野直子、山本さやか、柳川まどか、梅垣宏行
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京