Assessment of central nervous system function through autonomic nervous system in Alzheimer's disease
Project/Area Number |
21591510
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Nagoya University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yusuke 名古屋大学, 大学院・医学系研究科, 講師 (90378167)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 認知症 / 老化 / ストレス / アルツハイマー型認知症 / 心拍変動 / コリン作動性神経 / 海馬 / 神経心理検査 / 痴呆 |
Research Abstract |
In animal experiment the acute administration of cholinesterase inhibitor(ChEI) activated the sympathetic nervous system, while the chronic administration affected the parasympathetic nervous system. In the clinical study, we found the negative correlation between depressive mood and the activity of sympathetic nervous system in AD subjects.
|
Report
(4 results)
Research Products
(8 results)