A diffusion tensor imaging study of the microstructural abnormalities in the feedback pathways to the hypothalamus in atypical psychosis

• Project/Area Number: 21591512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: SHIROYAMA Takashi 三重大学, 医学部附属病院, 講師 (00252354)
• Co-Investigator(Kenkyū-buntansha): MAEDA Masayuki 三重大学, 医学部附属病院, 講師 (70219278)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 非定型精神病 / 視床下部 / 脳弓 / 脳白質 / 拡散テンソル画像 / 気分障害 / 統合失調症 / 双極性障害 / 海馬

Research Abstract

The microstructural abnormalities in the body of fornix in patients with atypical psychosis defined by Mitsuda and Hatotani were studied using diffusion tensor imaging. Our results suggested dysfunction of negative feedback pathway to the hypothalamus from hippocampus in atypical psychosis despite heterogeneity of the microstructural pathologies in the fornix.