Effect of cholinesterase inhibitor on symptoms and cerebral glucose metabolism in patients with dementia with Lewy bodies
Project/Area Number |
21591514
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
KAZUI Hiroaki 大阪大学, 医学系・研究科, 講師 (30346217)
|
Co-Investigator(Kenkyū-buntansha) |
HATAZAWA Jun 大阪大学, 医学系・研究科, 教授 (70198745)
ADACHI Hiroyoshi 大阪大学, 保健センター, 准教授 (00303785)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | レビー小体病 / 睡眠障害 / 幻視 / FDG-PET / アクチグラフ / コリンエステラーゼ阻害薬 / レビー小体型認知症 / ドネペジル / 認知機能 / アクチグラム / 睡眠覚醒リズム |
Research Abstract |
Cognitive function, neuropsychiatric symptoms, sleep disturbance, and cerebral glucose metabolism were evaluated in 9 patients with dementia with Lewy bodies before and after the administration of cholinesterase inhibitor(donepezil). Sleep disturbances were calculated from night-time activity, which was measured with a recording accelerometer called an ActiGraph. Cerebral glucose metabolism was measured with FDG-PET scan. Cognitive impairment, sleep disturbances, body movement during sleep, and hallucinations improved after donepezil treatment. Cerebral glucose metabolism in the right precuneus and posterior cingulated gyrus, and left middle frontal gyrus, orbitofrontal gyrus, precuneus, and cuneus improved after donepezil treatment.
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Report
(4 results)
Research Products
(118 results)
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[Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait2012
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Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
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Journal Title
Neurosci Lett
Volume: (Epub ahead of print)
Issue: 2
Pages: 204-208
DOI
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[Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia2012
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Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
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Journal Title
PLoS One
Volume: 7(1)
Issue: 1
Pages: e29780-e29780
DOI
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[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M.
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Dement Geriatr Cogn Disord Extra
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Pages: 20-30
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[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage.2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
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Journal Title
Dement Geriatr Cogn Disord Extra
Volume: 1
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[Journal Article] KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer's Disease, but Does Not Show Association with Disease in a Japanese Cohort.2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Volume: 25
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[Journal Article] Neuropsychiatric symptoms in patients with idiopathic Normal Pressure Hydrocephalus2009
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Kito Y, Kazui H, Kubo Y, Yoshida T, Takaya M, Wada T, Nomura K, Hashimoto M, Ohkawa S, Miyake H, Ishikawa M, Takeda M.
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Journal Title
Behav Neurol 21
Pages: 165-174
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Year and Date
2011-11-18
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International Psychogeriatric Association 15^<th> International Congress
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