| Project/Area Number |
21591514
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
KAZUI Hiroaki 大阪大学, 医学系・研究科, 講師 (30346217)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HATAZAWA Jun 大阪大学, 医学系・研究科, 教授 (70198745)
ADACHI Hiroyoshi 大阪大学, 保健センター, 准教授 (00303785)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | レビー小体病 / 睡眠障害 / 幻視 / FDG-PET / アクチグラフ / コリンエステラーゼ阻害薬 / レビー小体型認知症 / ドネペジル / 認知機能 / アクチグラム / 睡眠覚醒リズム |
|---|
| Research Abstract |
Cognitive function, neuropsychiatric symptoms, sleep disturbance, and cerebral glucose metabolism were evaluated in 9 patients with dementia with Lewy bodies before and after the administration of cholinesterase inhibitor(donepezil). Sleep disturbances were calculated from night-time activity, which was measured with a recording accelerometer called an ActiGraph. Cerebral glucose metabolism was measured with FDG-PET scan. Cognitive impairment, sleep disturbances, body movement during sleep, and hallucinations improved after donepezil treatment. Cerebral glucose metabolism in the right precuneus and posterior cingulated gyrus, and left middle frontal gyrus, orbitofrontal gyrus, precuneus, and cuneus improved after donepezil treatment.
|
