The investigating the molecular mechanisms of cognitive impairment due to cancer chemotherapy and its prevention
Project/Area Number |
21591515
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
TANIMUKAI Hitoshi 大阪大学, 大学院・医学系研究科, 特任助教(常勤) (60432481)
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Co-Investigator(Kenkyū-buntansha) |
KUDO Takashi 大阪大学, 大学院・医学系研究科, 准教授 (10273632)
MORIHARA Takashi 大阪大学, 大学院・医学系研究科, 助教 (90403196)
OKAMOTO Yoshiaki 大阪大学, 大学院・薬学研究科, 講師 (90432442)
TSUGANE Mamiko 大阪大学, 大学院・薬学研究科, 助教 (00469991)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 認知機能障害 / 抗がん剤 / ケモブレイン / 小胞体ストレス / 予防 / 認知機能 / がん化学療法 / Caspase4 / サイトカイン |
Research Abstract |
To investigate the molecular mechanisms of chemotherapy induced cognitive impairment, we studied the neuronal toxicity(NT) of paclitaxel(Px), fluorouracil(5-FU), and cyclophosphamide(CPA) on neuronal culture cells(SY5Y and SK-N-SH) and further investigated its relationship to endoplasmic reticulum stress(ER stress). Significant NT was observed in cells treated with Px and 5-FU in dose dependent manner, but not with CPA. In addition, the induction of both p-eIF2αand GRP78/ 94 were observed in cells by Px or 5-FU treatment. Pre-treatment of cells with Bip inducer X(BIX) reduced Px-induced NT but not 5-FU induced NT. These data suggest that Px induced NT probably relates to ER stress and BIX could prevent the Px induced NT as including chemobrain.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
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Journal Title
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Peer Reviewed
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[Presentation] "A retrospective chart review of agitation in terminal cancer patients2011
Author(s)
Okamoto Y, Nagase M, Tsuneto S, Tanimukai H, Matsuda Y, Okishiro N, Kumakura Y, Ono Y, Tsugane M, Takagi T, Uejima E.
Organizer
12^<th> Congress of the European Association for Palliative Care
Place of Presentation
Lisbon Congress Center, Portugal
Year and Date
2011-05-20
Related Report
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