| Project/Area Number |
21591515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
TANIMUKAI Hitoshi 大阪大学, 大学院・医学系研究科, 特任助教(常勤) (60432481)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Takashi 大阪大学, 大学院・医学系研究科, 准教授 (10273632)
MORIHARA Takashi 大阪大学, 大学院・医学系研究科, 助教 (90403196)
OKAMOTO Yoshiaki 大阪大学, 大学院・薬学研究科, 講師 (90432442)
TSUGANE Mamiko 大阪大学, 大学院・薬学研究科, 助教 (00469991)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 認知機能障害 / 抗がん剤 / ケモブレイン / 小胞体ストレス / 予防 / 認知機能 / がん化学療法 / Caspase4 / サイトカイン |
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| Research Abstract |
To investigate the molecular mechanisms of chemotherapy induced cognitive impairment, we studied the neuronal toxicity(NT) of paclitaxel(Px), fluorouracil(5-FU), and cyclophosphamide(CPA) on neuronal culture cells(SY5Y and SK-N-SH) and further investigated its relationship to endoplasmic reticulum stress(ER stress). Significant NT was observed in cells treated with Px and 5-FU in dose dependent manner, but not with CPA. In addition, the induction of both p-eIF2αand GRP78/ 94 were observed in cells by Px or 5-FU treatment. Pre-treatment of cells with Bip inducer X(BIX) reduced Px-induced NT but not 5-FU induced NT. These data suggest that Px induced NT probably relates to ER stress and BIX could prevent the Px induced NT as including chemobrain.
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