Diagnosis and prognosis of mild cognitive impairment

• Project/Area Number: 21591517
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Okayama University
• Principal Investigator: TERADA Seishi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (20332794)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 老年精神医学 / 軽度認知障害 / 認知症 / revised Addenbrooke's Cognitive Examination(ACE-R) / Frontal Assessment Battery(FAB) / Wisconsin Card Sorting Test(WCST) / 仮名拾いテスト / 繰り返し質問行動 / Addenbrooke's Cognitive Examination (ACE) / ウィスコンシン・カードソーティングテスト / 徘徊 / 弄便

Research Abstract

Mild cognitive impairment(MCI) is an important concept for preventing and treating dementia. However, the precise diagnosis of MCI in the practical clinical setting is difficult. In this research project, we developed a Japanese version of Addenbrooke's cognitive examination revised(ACE-R), and showed an excellent validity to diagnose MCI. Additionally, we clarified the neural substrates of several neuropsychological tests and abnormal behaviors in patients with dementia.

Research Products

• [Journal Article] Frontal assessment battery and brain perfusion imaging in Alzheimer's disease (2012)
  • Author(s): Oshima E, Terada S, Sato S, Ikeda C, Nagao S, Takeda N, Honda H, Yokota O, Uchitomi Y
  • Journal Title: International Psychogeriatrics Volume: (in press)
  • Peer Reviewed
• [Journal Article] Validation of the revised Addenbrooke's Cognitive Examination(ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population (2012)
  • Author(s): Yoshida H, Terada S, Honda H, Kishimoto Y, Takeda N, Oshima E, Hirayama K, Yokota O, Uchitomi Y
  • Journal Title: International Psychogeriatrics Volume: 24 Pages: 28-37
  • Peer Reviewed
• [Journal Article] Validation of the revised Addenbrooke's Cognitive Examination (ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population (2012)
  • Author(s): Yoshida H, Terada S, Honda H, et al
  • Journal Title: International Psychogeriatrics Volume: 24 Issue: 1 Pages: 28-37
  • DOI: 10.1017/s1041610211001190
  • Peer Reviewed
• [Journal Article] Frontal assessment battery and brain perfusion imaging in Alzheimer's disease (2012)
  • Author(s): Oshima E, Terada S, Sato S, et al
  • Journal Title: International Psychogeriatrics Volume: 24 Issue: 6 Pages: 994-1001
  • DOI: 10.1017/s1041610211002481
  • Peer Reviewed
• [Journal Article] Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion Imaging in mild Alzheimer's disease (2011)
  • Author(s): Terada S, Sato S, Honda H, Kishimoto Y, Takeda N, Oshima E, Yokota O, Uchitomi Y
  • Journal Title: International Psychogeriatrics Volume: 23 Pages: 1552-1559
  • Peer Reviewed
• [Journal Article] Kana Pick-out Test and brain perfusion imaging in Alzheimer's disease (2011)
  • Author(s): Kishimoto Y, Terada S, Sato S, Takeda N, Honda H, Yokota O, Uchitomi Y
  • Journal Title: International Psychogeriatrics Volume: 23 Pages: 546-553
  • Peer Reviewed
• [Journal Article] Validation of Addenbrooke's cognitive examination for detecting early dementia in a Japanese population (2011)
  • Author(s): Yoshida H, Terada S, Honda H, Ata T, Takeda N, Kishimoto Y, Oshima E, Ishihara T, Kuroda S
  • Journal Title: Psychiatry Research Volume: 185 Pages: 21-24
  • Peer Reviewed
• [Journal Article] Validation of Addenbrooke's cognitive examination for detecting early dementia in a Japanese population. (2011)
  • Author(s): Yoshida H, Terada S, Honda H, et al
  • Journal Title: Psychiatry Research Volume: 185 Pages: 21-24
  • Peer Reviewed
• [Journal Article] Kana Pick-out Test and brain perfusion imaging in Alzheimer's disease. (2011)
  • Author(s): Kishimoto Y, Terada S, Sato S, et al
  • Journal Title: International Psychogeriatrics
  • Peer Reviewed
• [Journal Article] Repetitive questioning behavior in Alzheimer's disease : relationship to regional cerebral blood flow (2010)
  • Author(s): Kishimoto Y, Terada S, Sato S, Yoshida H, Honda H, Takeda N, Oshima E, Ishihara T, Kuroda S
  • Journal Title: Psychiatry Research : Neuroimaging Volume: 184 Pages: 151-156
  • Peer Reviewed
• [Journal Article] Wandering and fecal smearing in people with dementia (2010)
  • Author(s): Ata T, Terada S, Yokota O, Ishihara T, Fujisawa Y, Sasaki K, Kuroda S
  • Journal Title: International Psychogeriatrics Volume: 22 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia (2010)
  • Author(s): Takeda N, Terada S, Sato S, Honda H, Yoshida H, Kishimoto Y, Kamata G, Oshima E, Ishihara T, Kuroda S
  • Journal Title: Dementia and geriatric cognitive disorders Volume: 29 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Repetitive questioning behavior in Alzheimer's disease : relationship to regional cerebral blood flow. (2010)
  • Author(s): Kishimoto Y, Terada S, Sato S, et al
  • Journal Title: Psychiatry Research : Neuroimaging Volume: 184 Pages: 151-156
  • Peer Reviewed
• [Journal Article] Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia (2010)
  • Author(s): Takeda N, Terada S, Sato S, et al
  • Journal Title: Dementia and geriatric cognitive disorders 29 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Wandering and fecal smearing in people with dementia (2010)
  • Author(s): Ata T, Terada S, Yokota O, et al
  • Journal Title: International Psychogeriatrics 22 Pages: 1-8
  • Peer Reviewed
• [Presentation] 軽度認知障害および認知症の検出における長谷川式認知症スケールと日本語版Addenbrooke's Cognitive Examination Revisedの診断精度の比較 (2011)
  • Author(s): 吉田英統, 寺田整司, 本田肇, 岸本由紀, 武田直也, 大島悦子, 平山啓介, 横田修, 内富庸介
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京(船堀)
• [Presentation] 認知障害を有する高齢者の意思決定能力評価法に関する検討 (2011)
  • Author(s): 大島悦子, 寺田整司, 今井奈緒, 矢部真弓, 土山璃沙, 池田智香子, 武田直也, 岸本由紀, 本田肇, 横田修, 内富庸介
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京(船堀)
• [Presentation] ウイスコンシン・カードテストにおけるPEN型保続と脳血流,アルツハイマー病患者を対象として (2011)
  • Author(s): 寺田整司, 佐藤修平, 本田肇, 岸本由紀, 武田直也, 大島悦子, 池田智香子, 横田修, 内富庸介
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京(船堀)
• [Presentation] Insomnia and quality of life of patients with dementia in long-term care facilities (2011)
  • Author(s): Terada S, Ikeda C, Nagao S, Takeda N, Kishimoto Y, Yoshida H, Oshima E, Yokota O, Uchitomi Y
  • Organizer: The 6th World Congress of World Sleep Federation(Worldsleep 2011)
  • Place of Presentation: Kyoto Japan
• [Presentation] Addenbrooke's Cognitive Examination Revised(ACE-R)日本語版の作成 (2011)
  • Author(s): 吉田英統, 寺田整司, 本田肇, 岸本由紀, 武田直也, 大島悦子, 平山啓介, 横田修, 内富庸介
  • Organizer: 第26回日本老年精神医学会
  • Place of Presentation: 東京
• [Presentation] Addenbrooke's Cognitive Examination Revised (ACE-R)日本語版の作成 (2011)
  • Author(s): 吉田英統, 寺田整司, 本田肇, 他
  • Organizer: 第26回日本老年精神医学会
  • Place of Presentation: 東京
• [Presentation] Insomnia and quality of life of patients with dementia in long-term care facilities (2011)
  • Author(s): Terada S, Ikeda C, Nagao S, et al
  • Organizer: The 6th World Congress of World Sleep Federation
  • Place of Presentation: Kyoto, Japan
• [Presentation] 軽度認知障害および認知症の検出における長谷川式認知症スケールと日本語版Addenbrooke's Cognitive Examination Revisedの診断精度の比較 (2011)
  • Author(s): 古田英統, 寺田整司, 本田肇, 他
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
• [Presentation] 認知障害を有する高齢者の意思決定能力評価法に関する検討 (2011)
  • Author(s): 大島悦子, 寺田整司, 今井奈緒, 他
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
• [Presentation] ウイスコンシン・カードテストにおけるPEN型保続と脳血流,アルツハイマー病患者を対象として (2011)
  • Author(s): 寺田整司, 佐藤修平, 本田肇, 他
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: 東京
• [Presentation] アルツハイマー病におけるrepetitive questioning(繰り返し質問)と脳血流の関連 (2010)
  • Author(s): 岸本由紀, 寺田整司, 佐藤修平, 吉田英統, 武田直也, 大島悦子, 本田肇, 石原武士, 黒田重利
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-05
• [Presentation] アルツハイマー病におけるrepetitive questioning(繰り返し質問)と脳血流の関連 (2010)
  • Author(s): 岸本由紀, 寺田整司, 佐藤修平, 他
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-11-05
• [Presentation] 早期認知症におけるウィスコンシンカード分類テスト(WCST)と脳血流画像 (2010)
  • Author(s): 武田直也, 寺田整司, 佐藤修平, 本田肇, 吉田英統, 岸本由紀, 鎌田豪介, 大島悦子, 石原武士, 黒田重利
  • Organizer: 第25回日本老年精神医学会
  • Place of Presentation: 熊本
  • Year and Date: 2010-06-24
• [Presentation] 早期認知症におけるウイスコンシンカード分類テスト(WCST)と脳血流画像 (2010)
  • Author(s): 武田直也, 寺田整司, 佐藤修平, 他
  • Organizer: 第25回日本老年精神医学会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-06-24
• [Presentation] Addenbrooke's cognitive examination(ACE)日本語版作成と信頼性、妥当性の検証 (2009)
  • Author(s): 吉田英統、寺田整司、本田肇、阿多敏江、武田直也、岸本由紀、大島悦子、石原武士、黒田重利
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-20
• [Presentation] Addenbrooke's cognitive examination(ACE)日本語版作成と信頼性、妥当性の検証 (2009)
  • Author(s): 吉田英統, 寺田整司, 他
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館(仙台)
  • Year and Date: 2009-11-20
• [Presentation] Wisconsin card sorting test and brain perfusion imaging in early dementia (2009)
  • Author(s): Takeda N, Terada S, Sato S, Honda H, Yoshida H, Kishimoto Y, Kamata G, Oshima E, Ishihara T, Kuroda S
  • Organizer: International Neuropsychiatric association(INA) 2009
  • Place of Presentation: Kobe Japan
  • Year and Date: 2009-09-12
• [Presentation] Repetitive questioning behavior in Alzheimer's disease Relationship to regional cerebral blood flow (2009)
  • Author(s): Kishimoto Y, Terada S, Sato S, Takeda N, Yoshida H, Honda H, Oshima E, Ishihara T, Kuroda S
  • Organizer: International Neuropsychiatric association(INA) 2009
  • Place of Presentation: Kobe Japan
  • Year and Date: 2009-09-12
• [Presentation] Repetitive questioning behavior in Alzheimer's disease Relationship to regional cerebral blood flow (2009)
  • Author(s): Kishimoto Y, Terada S, Sato S, et al
  • Organizer: International Neuropsychiatric association, 2009
  • Place of Presentation: Kobe International Conference Center(Kobe)
  • Year and Date: 2009-09-12
• [Presentation] Wisconsin card sorting test and brain perfusion imaging in early dementia (2009)
  • Author(s): Takeda N, Terada S, Sato S, et al
  • Organizer: International Neuropsychiatric association, 2009
  • Place of Presentation: Kobe International Conference Center(Kobe)
  • Year and Date: 2009-09-12
• [Remarks]
  • URL: https://sites.google.com/site/okayamaneuropsy5/