| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Depression is characterized by enhanced self-referential processing of negative emotional stimuli. Imaging studies have suggested that activation of both the medial prefrontal(MPFC) and anterior cingulate cortices(ACC) is associated with self-referential processing. However, whether this pattern of activation occurs in depressed individuals during the self-referential processing of the emotional stimuli had not been investigated to date. Thus, we have studied some experiments and got some following results. Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the ACC during the self-referential processing of negative words. Activity in the MPFC and the ACC during self-referential processing of negative stimuli were decreased in the depressive patients following CBT. These results showed that improvement of depressive symptoms was associated with attenuation of the MPFC and the ACC activation during self-referential processing of negative emotion.
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