Brain imaging studies on neural basis of self reference in depression
| Project/Area Number |
21591518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAMOTO Yasumasa 広島大学, 大学院・医歯薬学総合研究科, 講師 (70314763)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 自己 / 認知 / 情動 / うつ病 / fMRI / 自己認知 / 認知行動療法 / 内側前頭前野 / 前帯状回 |
|---|
| Research Abstract |
Depression is characterized by enhanced self-referential processing of negative emotional stimuli. Imaging studies have suggested that activation of both the medial prefrontal(MPFC) and anterior cingulate cortices(ACC) is associated with self-referential processing. However, whether this pattern of activation occurs in depressed individuals during the self-referential processing of the emotional stimuli had not been investigated to date. Thus, we have studied some experiments and got some following results. Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the ACC during the self-referential processing of negative words. Activity in the MPFC and the ACC during self-referential processing of negative stimuli were decreased in the depressive patients following CBT. These results showed that improvement of depressive symptoms was associated with attenuation of the MPFC and the ACC activation during self-referential processing of negative emotion.
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Report
(4 results)
Research Products
(6 results)
