Neural correlates of plasma acylated ghrelin level in individuals with mood disorders
Project/Area Number |
21591519
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Yamaguchi University |
Principal Investigator |
MATSUO Koji 山口大学, 医学部附属病院, 講師 (00292912)
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Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Toshio 山口大学, 医学部附属病院, 助教 (60526896)
OTSUKI Koji 山口大学, 大学院・医学系研究科, 助教 (10535256)
内田 周作 山口大学, 大学院・医学系研究科, 助教 (10403669)
江頭 一輝 山口大学, 医学部附属病院, 助教 (90437624)
渡辺 義文 山口大学, 大学院・医学系研究科, 教授 (90182964)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | うつ病 / グレリン / MRI / 気分障害 / レプチン / 前頭葉機能 |
Research Abstract |
There was no significant difference in plasma acylated ghrelin level between patients with major depressive disorder(MDD) and healthy subjects. In the MDD group, ghrelin levels positively correlated with the severity of reduced appetite. Ghrelin levels negatively correlated with gray matter volume of the ventral tegmental area(VTA) in the total sample. The patients with MDD showed significantly smaller VTA gray matter volume compared to healthy subjects. Our findings suggest that plasma acylated ghrelin is associated with neural abnormalities of the pleasure/ reward system and may be involved in the pathophysiology of MDD.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 12011
Author(s)
Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y
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Journal Title
Proceedings of the National Academy of Science of the United States of America
Volume: 108(4)
Pages: 1681-1686
Related Report
Peer Reviewed
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[Journal Article] Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder2009
Author(s)
Matsuo K, Nicoletti MA, Peluso MAM, Hatch JP, Nemoto K, Watanabe Y, Nery FG, Monkul ES, Zunta-Soares GB, Bowden CL, Soares JC
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Journal Title
Bipolar Disorders
Volume: 11(6)
Pages: 628-636
Related Report
Peer Reviewed
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[Journal Article] Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder2009
Author(s)
Matsuo K, Walss-Bass C, Nery FG, Nicoletti MA, Hatch JP, Frey BN, Monkul ES, Zunta-Soares GB, Bowden CL, Escamilla MA, Soares JC
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Journal Title
Neuropsychopharmacology
Volume: 34(8)
Pages: 1904-1913
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
松尾幸治
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Journal Title
気分障害およびPTSDにおける脳機能病態(中山書店)
Pages: 134-143
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[Presentation] Association of Plasma Ghrelin Level and Morphometric Abnormalities in Patients with Mood Disorders2011
Author(s)
Matsuo K, Nakano M, Nakashima M, Kobayashi A, Hara K, Fujii Y, Hashimoto A, Egashira K, Uchida S, Matsubara T, Watanabe Y
Organizer
17th Annual meeting of the organization on Human Brain Mapping
Place of Presentation
ケベック、カナダ
Year and Date
2011-06-27
Related Report
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[Presentation] NIRS study of brain hemodynamic response during a stop signal task in children2011
Author(s)
Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Egashira K, Matsushige T, Matsubara T, Ichiyama T, Watanabe Y
Organizer
17th Annual Meeting of the Organization on Human Brain Mapping
Place of Presentation
Quebec City, Canada
Year and Date
2011-06-19
Related Report
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[Presentation] Neural correlates of motivational behavior with mesolimbic pathway in major depressive disorder2011
Author(s)
Nakano M, Matsuo K, Nakashima M, Egashira K, Matsubara T, Furukawa M, Takahashi K, Nemoto K, Masaki H, Matsunaga N, Watanabe Y
Organizer
17th Annual Meeting of Human Brain Mapping
Place of Presentation
Quebec City, Canada
Year and Date
2011-06-17
Related Report
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[Presentation] 気分障害患者におけるグレリン濃度と脳形態異常との関連2011
Author(s)
松尾幸治, 中野雅之, 中島麻美, 古林亜由美, 原久美子, 藤井優子, 橋本亜希子, 江頭一輝, 内田周作, 松原敏郎, 渡邉義文
Organizer
第33回日本生物学的精神医学会
Place of Presentation
東京ホテルグランパシフィックLE DAIBA
Year and Date
2011-05-22
Related Report
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[Presentation] Morphometric correlate of decision making under ambiguity and risk2010
Author(s)
Nakano M, Matsuo K, Nakashima M, Egashira K, Matsubara T, Furukawa M, Takahashi K, Nemoto K, Masaki H, Matsunaga N, Watanabe Y
Organizer
16th Annual Meeting of the Organization for Human Brain Mapping
Place of Presentation
Barcelona, Spain
Year and Date
2010-06-09
Related Report
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