Clinical and neuroscientific study of schizophrenia with reference to cognitive function and QOL.

• Project/Area Number: 21591520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: OHMORI Tetsuro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00221135)
• Co-Investigator(Kenkyū-buntansha): SUMITANI Satsuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (90346594)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 認知機能 / QOL / 脳画像 / 分子遺伝学

Research Abstract

The main purpose of the present study was to examine the relationship between cognitive dysfunction and clinical symptoms as well as quality of life(QOL) in schizophrenia. The results showed that cognitive dysfunction correlated with negative symptoms and extrapyramidal symptoms. Cognitive dysfunction also showed correlation with objective but not subjective QOL. Levels of life skills correlated with speed of processing domain of cognitive function.

Research Products

• [Journal Article] Multi-channel near-infrared spectroscopy reveals reduced activation in the prefrontal cortex during the facial expression processing in patients with pervasive developmental disorders (2012)
  • Author(s): Nakadoi Y, Sumitani S, Watanabe Y, Akiyama M, Yamashita N, Ohmori T
  • Journal Title: Psychiatry Clin Neurosci Volume: 66(1) Issue: 1 Pages: 26-33
  • DOI: 10.1111/j.1440-1819.2011.02290.x
  • Peer Reviewed
• [Journal Article] Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task (2012)
  • Author(s): Taniguchi K, Sumitani S, Watanabe Y, Akiyama M, Ohmori T
  • Journal Title: The Journal of Medical Investigation Volume: 59 Issue: 1,2 Pages: 45-52
  • DOI: 10.2152/jmi.59.45
  • NAID: 130004465270
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed
• [Journal Article] MRSを用いた統合失調症研究 (2011)
  • Author(s): 中瀧理仁, 久保弘子, 住谷さつき, 大森哲郎
  • Journal Title: 精神科治療学 Volume: 26(11) Pages: 1427-1433
  • Peer Reviewed
• [Journal Article] 【精神科領域における画像診断の展望】精神疾患とMRS (2011)
  • Author(s): 中瀧理仁, 大森哲郎
  • Journal Title: 最新精神医学 Volume: 16(3) Pages: 303-309
  • Peer Reviewed
• [Journal Article] 認知機能とQOLを視野に入れた統合失調症の薬物療法 (2011)
  • Author(s): 大森哲郎
  • Journal Title: 精神神経学雑誌 Volume: 113(1) Pages: 111-116
  • NAID: 10028060625
  • Peer Reviewed
• [Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia (2011)
  • Author(s): Ueoka Y, Tomotake M, Tanaka T, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 15 ; 35(1) Issue: 1 Pages: 53-9
  • DOI: 10.1016/j.pnpbp.2010.08.018
  • Peer Reviewed
• [Journal Article] 【脳の機能と統合失調症-新たな診断と治療への展望-I】MRSを用いた統合失調症研究 (2011)
  • Author(s): 中瀧理仁
  • Journal Title: 精神科治療学 Volume: 26(11) Pages: 1427-1433
  • Peer Reviewed
• [Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia. (2011)
  • Author(s): Ueoka Y, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: Jan 15;35(1) Pages: 53-9
  • Peer Reviewed
• [Journal Article] GABA concentration in schizophrenia patients and the effects of antipsychotic medication : A proton magnetic resonance spectroscopy study (2010)
  • Author(s): Tayoshi S, Nakataki M, Sumitani S, Taniguchi K, Shibuya-Tayoshi S, Numata S, Iga J, Ueno S, Harada M, Ohmori T
  • Journal Title: Schizophr Res Volume: 117(1) Issue: 1 Pages: 83-91
  • DOI: 10.1016/j.schres.2009.11.011
  • Peer Reviewed
• [Journal Article] Association study between the pericentrin(PCNT) gene and schizophrenia (2010)
  • Author(s): Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, Hashimoto R, Takeda M, Itakura M, Ueno S, Ohmori T
  • Journal Title: Neuromolecular Med Volume: 12(3) Issue: 3 Pages: 243-7
  • DOI: 10.1007/s12017-009-8106-x
  • Peer Reviewed
• [Journal Article] Association study between the pericentrin (PCNT) gene and schizophrenia. (2010)
  • Author(s): Numata S, et al.
  • Journal Title: Neuromolecular Med Volume: Sep;12(3) Pages: 243-7
  • Peer Reviewed
• [Journal Article] GABA concentration in schizophrenia patients and the effects of antipsychotic medication : a proton magnetic resonance spectroscopy study. (2010)
  • Author(s): Tayoshi S, et al.
  • Journal Title: Schizophr Res. Mar ; 117(1) Pages: 83-91
  • Peer Reviewed
• [Journal Article] Positive association of the pericentrin(PCNT) gene with major depressive disorder in the Japanese population (2009)
  • Author(s): Numata S, Iga J, Nakataki M, Tayoshi S, Tanahashi T, Itakura M, Ueno S, Ohmori T
  • Journal Title: J Psychiatry Neurosci Volume: 34(3) Pages: 195-8
  • Peer Reviewed
• [Journal Article] Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population (2009)
  • Author(s): Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T
  • Journal Title: Am J Med Genet Volume: 150 Issue: 4 Pages: 527
  • DOI: 10.1002/ajmg.b.30852
  • URL: https://pure.teikyo.jp/en/publications/b8fb0ce1-0217-467a-88b5-af4b0b765b23
  • Peer Reviewed
• [Journal Article] No association between Rho-associated coiled-coil forming protein serine/ threonine kinase1 gene and schizophrenia in the Japanese population (2009)
  • Author(s): Nakataki M, Numata S, Iga J, Tayoshi S, Tayoshi-Shibuya S, Song H, Tanahashi T, Itakura M, Ueno S, Ohmori T
  • Journal Title: Psychiatr Genet Volume: 19(3) Issue: 3 Pages: 162-162
  • DOI: 10.1097/ypg.0b013e32832a5030
  • Peer Reviewed
• [Journal Article] Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population. (2009)
  • Author(s): Numata S, et al.
  • Journal Title: J Psychiatry Neurosci. May ; 34(3) Pages: 195-198
  • Peer Reviewed
• [Journal Article] Gene expression and association analyses of the phosphodiest erase 4B (PDE4B) gene in major depressive disorder in the Jananese population. (2009)
  • Author(s): Numata S, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Jun 5 ; 150B(4) Pages: 527-534
  • Peer Reviewed
• [Journal Article] No association between Rho-associated coiled-coil forming protein serine/threonine kinasel gene and schizophrenia in the Japanese population. (2009)
  • Author(s): Nakataki M, et al.
  • Journal Title: Psychiatr Genet. JUN ; 19(3) Pages: 162-162
  • Peer Reviewed
• [Journal Article] Association Study Between the Pericentrin (PCNT) Gene and Schizophrenia. (2009)
  • Author(s): Numata S, et al.
  • Journal Title: Neuromolecular Med. 2009 Nov 24.(Epub ahead of print)
  • Peer Reviewed
• [Presentation] 市民公開講座薬物療法について当事者・家族が望む研究とは (2012)
  • Author(s): 大森哲郎
  • Organizer: 統合失調症学会
  • Place of Presentation: 愛知県産業労働センター(名古屋市)
  • Year and Date: 2012-03-17
• [Presentation] 市民公開講座薬物療法について当事者・家族が望む研究とは (2012)
  • Author(s): 大森哲郎
  • Organizer: 統合失調症学会
  • Place of Presentation: 名古屋市(愛知県産業労働センター)(招待講演)
  • Year and Date: 2012-03-17
• [Presentation] 子どもと大人の精神疾患の連続性と非連続性会長講演 (2011)
  • Author(s): 大森哲郎
  • Organizer: 第52回児童青年精神医学会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2011-11-11
• [Presentation] 子どもと大人の精神疾患の連続性と非連続性会長講演 (2011)
  • Author(s): 大森哲郎
  • Organizer: 第52回児童青年精神医学会
  • Place of Presentation: 徳島県(あわぎんホール)(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Amino acid neurotransmission in schizophrenia patients and the effects of antipsychotic medication : A proton magnetic resonance spectroscopy study (2011)
  • Author(s): Nakataki M
  • Organizer: 10^<th> World Conbress of Biological Psychiatry
  • Place of Presentation: Prague Congress Centre(Czech Republic, Prague)
  • Year and Date: 2011-06-02
• [Presentation] Amino acid neurotransmission in schizophrenia patients and the effects of antipsychotic medication : A proton magnetic resonance spectroscopy study (2011)
  • Author(s): Masahito Nakataki
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic.(Prague Congress Centre)
  • Year and Date: 2011-06-02
• [Presentation] Effects of Lithium on the Cognitive Function in healthy Volunteers (2011)
  • Author(s): Kubo H
  • Organizer: 2^<nd> Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Grand Hilton Seoul(韓国, Seoul)
• [Presentation] Effects of Lithium on the Cognitive Function in healthy Volunteers (2011)
  • Author(s): Hiroko Kubo
  • Organizer: The 2nd Congress of Asian College of Neuropsyc hopharmacology
  • Place of Presentation: Seoul.韓国(Grand Hilton Seoul)
• [Presentation] 統合失調症研究におけるMRS,シンポジウム画像研究は統合失調症の病態をどこまであきらかにしたか (2010)
  • Author(s): 中瀧理仁
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(北九州市)
  • Year and Date: 2010-10-09
• [Presentation] 統合失調症研究におけるMRS,シンポジウム 画像研究は統合失調症の病態をどこまであきらかにしたか (2010)
  • Author(s): 中瀧理仁
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-09
• [Presentation] 日本人におけるcannabinoid receptor 1遺伝子多型とbody mass index、および統合失調症との関連研究 (2010)
  • Author(s): 渡部真也
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(北九州市)
  • Year and Date: 2010-10-08
• [Presentation] 日本人におけるcannabinoid receptor 1遺伝子多型とbody mass index、および統合失調症との関連研究 (2010)
  • Author(s): 渡部真也
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-08
• [Presentation] MRS.スタディグループ5脳画像から見た精神薬理-マクロとミクロの接点 (2010)
  • Author(s): 中瀧理仁
  • Organizer: 第20回日本臨床精神神経薬理学会
  • Place of Presentation: 仙台国際センター(仙台市)
  • Year and Date: 2010-09-16
• [Presentation] Relation among cognitive dysfunction, quality of life and clinical symptoms in schizophrenia patients統合失調症の認知機能障害と治療法の開発 (2010)
  • Author(s): Tomotake M
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台国際センター(仙台市)
  • Year and Date: 2010-09-16
• [Presentation] Relation among cognitive dysfunction, quality of life and clinical symptoms in schizophrenia patients.<シンポジウム>統合失調症の認知機能障害と治療法の開発 (2010)
  • Author(s): Tomotake M
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-16
• [Presentation] MRS.スタディグループ5 脳画像から見た精神薬理-マクロとミクロの接点 (2010)
  • Author(s): 中瀧理仁
  • Organizer: 第20回日本臨床精神神経薬理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-16
• [Presentation] Association study of cannabinoid receptor 1 gene and schizophrenia and body mass index in a Japanese population. (2010)
  • Author(s): Shin-ya Watanabe
  • Organizer: CINP.
  • Place of Presentation: HONG KONG
  • Year and Date: 2010-06-08
• [Presentation] 認知機能とQOLを視野に入れた統合失調症の薬物療法 (2010)
  • Author(s): 大森哲郎
  • Organizer: 第106回日本精神神経学会
  • Place of Presentation: 広島国際会議場,(広島市)
  • Year and Date: 2010-05-22
• [Presentation] 認知機能とQOLを視野に入れた統合失調症の薬物療法 (2010)
  • Author(s): 大森哲郎
  • Organizer: 第106回日本精神神経学会学術総会
  • Place of Presentation: 広島
  • Year and Date: 2010-05-22
• [Presentation] Effect of cognitive dysfunction on subjective quality of life in people with schizophrenia (2010)
  • Author(s): Tomotake M
  • Organizer: British Association for Behavioural & Cognitive Psychotherapies : 38th BABCP Annual Conference & Workshops
  • Place of Presentation: University of Manchester(UK, Manchester)
• [Presentation] Cognitive restructuring of negative old memories of parents was effective in the treatment of an adolescent patient with marked social withdrawal (2010)
  • Author(s): Tomotake M
  • Organizer: British Association for Behavioural & Cognitive Psychotherapies : 38th BABCP Annual Conference & Workshops
  • Place of Presentation: University of Manchester(UK, Manchester)
• [Presentation] Association study of cannabinoid receptor 1 gene and schizophrenia and body mass index in a Japanese population (2010)
  • Author(s): Watanabe S
  • Organizer: XXVII CINP CONGRESS 2010 WORLD CONGRESS
  • Place of Presentation: Hong Kong Convention and Exhibition Centre(China, Hong Kong)
• [Presentation] Effect of cognitive dysfunction on subjective quality of life in people with schizophrenia. British Association for Behavioural & Cognitive Psychotherapies (2010)
  • Author(s): Tomotake M
  • Organizer: 38th Annual Conference, Manchester
  • Place of Presentation: UK
• [Presentation] Cognitive restructuring of negative old memories of parents was effective in the treatment of an adolescent patient with marked social withdrawal. British Association for Behavioural & Cognitive Psychotherapies (2010)
  • Author(s): Tomotake M
  • Organizer: 38th Annual Conference, Manchester
  • Place of Presentation: UK
• [Presentation] Antipsychotic medication affect the GABA concentration in schizophrenic patients : A proton magnetic resonance spectroscopy study (2009)
  • Author(s): Nakataki M
  • Organizer: 1^<st> Asian Congress of Neuropsychopharmacology
  • Place of Presentation: Kyoto International Conference Center(京都市)
  • Year and Date: 2009-11-13
• [Presentation] Relationship between Cognitive function and Clinical Symptoms in people with Schizophrenia (2009)
  • Author(s): Tanaka T
  • Organizer: 1^<st> Asian Congress of Neuropsychopharmacology
  • Place of Presentation: Kyoto International Conference Center(京都市)
  • Year and Date: 2009-11-13
• [Presentation] Quality of Life and Cognitive Dysfunction in People with Schizophrenia (2009)
  • Author(s): Ueoka Y
  • Organizer: 1^<st> Asian Congress of Neuropsychopharmacology
  • Place of Presentation: Kyoto International Conference Center(京都市)
  • Year and Date: 2009-11-13
• [Presentation] Antipsychotic medication affects the GABA concentration in schizophrenic patients : A proton magnetic resonance spectroscopy study (2009)
  • Author(s): Masahito Nakataki
  • Organizer: 第1回アジア神経精神薬理学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-11-13
• [Presentation] Relationship between cognitive function and clinical symptoms in people with schizophrenia (2009)
  • Author(s): Tsunehiko Tanaka
  • Organizer: 第1回アジア神経精神薬理学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-11-13
• [Presentation] Quality of life and cognitive dysfunction in people with schizophrenia (2009)
  • Author(s): Yoshinori Ueoka
  • Organizer: 第1回アジア神経精神薬理学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-11-13
• [Presentation] 多チャンネル近赤外線スペクトロスコピーを用いた統合失調症患者の前頭葉血流変化の検討 (2009)
  • Author(s): 谷口京子
  • Organizer: 第31回日本生物学的精神医学会,国立京都国際会館
  • Place of Presentation: 京都市
  • Year and Date: 2009-04-25
• [Presentation] 多チャンネル近赤外線スペクトロスコピーを用いた統合失調症患者の前頭葉血流変化の検討 (2009)
  • Author(s): 谷口京子
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都市