Plasma adipocytokines, and BDNF levels in patients with eating disorders : Relationship with short-term outcome

• Project/Area Number: 21591525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka City University
• Principal Investigator: NAGATA Toshihiko 大阪市立大学, 大学院・医学研究科, 准教授 (80237528)
• Co-Investigator(Kenkyū-buntansha): YAMADA Hisashi 大阪市立大学, 大学院・医学研究科, 病院講師 (20464646) ; FUKUHARA Hidehiro 大阪市立大学, 大学院・医学研究科, 病院講師 (10464645)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: Brain-derived neurotrophic factor / adipocytokines / bulimia nervosa / anorexia nervosa / BDNF / Pro-BDNF / 神経性過食症 / アディポサイトカイン / Adiponectin / Resistin / Leptin / 摂食障害 / 脳由来養因子 / サイトカイン

Research Abstract

Plasma resisitin levels in patients with bulimia nervosa were significantly lower than in controls, and the level was negatively correlated with the frequency of binge eating, depressive and anxiety scores. Plasma BDNF levels in patients with bulimia nervosa were significantly lower than in controls, but significantly icreased after short-term inpatient treatment.

Research Products

• [Journal Article] Comorbid social withdrawal (hikikomori) in outpatients with social anxiety disorder : Clinical characteristics and treatment response in a case series (2013)
  • Author(s): Nagata, T., Yamada, H., Teo, A.R., Yoshimura, C.Nakajima, T., van Vliet, I.
  • Journal Title: International Journal of Social Psychiatry Volume: (印刷中) Issue: 1 Pages: 73-78
  • DOI: 10.1177/0020764011423184
  • Peer Reviewed
• [Journal Article] Recovery of low plasma BDNF over the course of treatment among patients with bulimia nervosa (2012)
  • Author(s): Yamada H, Yoshimura C, Nakajima T, Nagata T
  • Journal Title: Psychiatry Res Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] No association of Brain-Derived Neurotrophic Factor Val66Met Polymorphism with Anorexia Nervosa in Japanese (2012)
  • Author(s): Ando, T., Ishikawa T., Hotta M., Naruo T., Okabe, K., Nakahara, T., Takii, M., Kawai, K., Mera, T., Nakamoto, C., Takei, M., Yamaguchi, C., Nagata, T., Okamoto, Y., Ookuma, K., Koide, M., Yamanaka, T., Murata, S., Tamura, N., Kiriike, N., Ichimaru, Y., Komaki, G.
  • Journal Title: Am J Med Genet Part B Neuropsychiatric Genetics Volume: 159B Pages: 48-52
• [Journal Article] Recovering of low plasma BDNF in the course of treatment a mong patients with Bulimia Nervosa (2012)
  • Author(s): Yamada H, Yoshimura C, Nakajima T, Nagata T
  • Journal Title: Psychiatry Reserch Volume: (印刷中) Issue: 3 Pages: 448-451
  • DOI: 10.1016/j.psychres.2011.12.015
  • Peer Reviewed
• [Journal Article] No association of Brain-Derived Neurotrophic Factor Val66Met Polymorphism with Anorexla Nervosa in Japanese (2012)
  • Author(s): Ando T, et al., 22人中13番目
  • Journal Title: Am J Med Genet Part B Volume: 159B Issue: 1 Pages: 48-52
  • DOI: 10.1002/ajmg.b.32000
  • Peer Reviewed
• [Journal Article] Correlations between the offensive subtype of social anxiety disorder and personality disorders (2011)
  • Author(s): Nagata, T., Matsunaga, H., van Vliet, I., Yamada, H., Fukuhara, H., Yoshimura, C., Kiriike, N.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Issue: 4 Pages: 341-348
  • DOI: 10.1111/j.1440-1819.2011.02224.x
  • Peer Reviewed
• [Journal Article] Relationship between the offensive subtype of social anxiety disorder and personality disorders. (2011)
  • Author(s): Nagata, T., et al.
  • Journal Title: Psychiatry Clin Neurosci Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders : a retrospective survival analysis (2010)
  • Author(s): Ando, T., Komaki, G., Nishimura, H., Naruo, T., Okabe, K., Kawai, K., Takii, M., Oka, T., Kodama, N., Nakamoto, C., Ishikawa, T., Suzuki-Hotta, M., Minatozaki, K., Yamaguchi, C., Nishizono-Maher, A., Kono, M., Kajiwara, S., Suematsu, H., Tomita, Y., Ebana, S., Okamoto, Y., Nagata, K., Nakai, Y., Koide, M., Kobayashi, N., Kurokawa, N., Nagata, T., Kiriike, N., Takenaka, Y., Nagamine, K., Ookuma, K. & Murata, S.
  • Journal Title: Psychiatr Genet Volume: 20 Pages: 153-159
• [Journal Article] 摂食障害患者の変化への段階と早期治療脱落 (2010)
  • Author(s): 山田恒, 永田利彦, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 52(9) Pages: 853-861
  • NAID: 40017257030
• [Journal Article] ひきこもる摂食障害を就労支援へつなげることのできた2症例 (2010)
  • Author(s): 永田利彦, 村上澄子, 熊谷幸市, 山田恒, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 52 Pages: 17-24
  • NAID: 40016905739
• [Journal Article] Clinical features and treatment characteristics of compulsive hoarding in Japanese patients with obsessive compulsive disorder. (2010)
  • Author(s): Matsunaga, H., Hayashida, K., Kiriike, N., Nagata, T., Stein, D.
  • Journal Title: CNS Spectr Volume: 15 Pages: 258-265
  • Peer Reviewed
• [Journal Article] A ghrelin gene variant may predict crossover rate from restricting-… (2010)
  • Author(s): Ando, T., ほか(27番目)
  • Journal Title: Psychiatr Genet Volume: 20 Pages: 153-159
  • Peer Reviewed
• [Journal Article] 摂食障害患者の変化への段階と早期治療脱落 (2010)
  • Author(s): 山田恒, 永田利彦, ほか
  • Journal Title: 精神医学 Volume: 52 Pages: 853-861
  • NAID: 40017257030
  • Peer Reviewed
• [Journal Article] ひきこもる摂食障害を就労支援へつなげることのできた2症例 (2010)
  • Author(s): 永田利彦, 他
  • Journal Title: 精神医学 52 Pages: 17-24
  • NAID: 40016905739
  • Peer Reviewed
• [Journal Article] 就労支援事業が就労につながった全般性社交不安障害(回避性パーソナリティ障害)の2症例 (2009)
  • Author(s): 永田利彦, 村上澄子, 熊谷幸市, 山田恒, 吉村知穂, 中島豪紀, 切池信夫
  • Journal Title: 精神医学 Volume: 51 Pages: 1157-1163
  • NAID: 40016849354
• [Journal Article] A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder (2009)
  • Author(s): Matsunaga H, Nagata T, et al.
  • Journal Title: J Clin Psychiatry 70 Pages: 863-868
  • Peer Reviewed
• [Journal Article] 就労支援事業が就労につながった全般性社交不安障害(回避性パーソナリティ障害)の2症例 (2009)
  • Author(s): 永田利彦, 他
  • Journal Title: 精神医学 51 Pages: 129-135
  • NAID: 40016849354
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Nagata T, et al.
  • Journal Title: Newspaper advertisement recruitment of the subjects with social anxiety disorder and its relationship to taijin-kyofusho(Nova Biomedical Books) Pages: 251-259
• [Presentation] Comparison of comorbidity between female social anxiety disorder… (2010)
  • Author(s): Nagata, T., et al.
  • Organizer: Eating Disorders Research Society
  • Place of Presentation: Cambridge, USA
  • Year and Date: 2010-10-07
• [Presentation] マインドフルネスと不安障害治療 (2010)
  • Author(s): 永田利彦
  • Organizer: 第2回日本不安障害学会総会
  • Place of Presentation: エルおおさか
  • Year and Date: 2010-03-06
• [Presentation] Comparison of comorbidity between female social anxiety disorder patients with and without eating disorders (2010)
  • Author(s): Nagata, T. et al
  • Organizer: Eating Disorders Research Society 16th Annual Meeting
  • Place of Presentation: Cambridge, Massachusetts, USA
• [Presentation] 自傷と弁証法的行動療法 (2009)
  • Author(s): 永田利彦
  • Organizer: 第9回日本外来精神医療学会
  • Place of Presentation: 第9回日本外来精神医療学会(大阪国際会議場)
  • Year and Date: 2009-08-08
• [Book] 摂食障害治療ガイドライン (2012)
  • Author(s): 永田利彦
  • Publisher: 医学出版
• [Book] 病理と病態(p15-18)「摂食障害治療ガイドライン」 (2012)
  • Author(s): 永田利彦(分担執筆)
  • Total Pages: 303
  • Publisher: 医学書院
• [Book] 摂食障害 (2011)
  • Author(s): 永田利彦
  • Publisher: 医学書院
• [Book] 摂食障害の入院治療-より現実的な着地点を目指して (2010)
  • Author(s): 永田利彦
  • Publisher: 中山書店
• [Book] 精神科臨床リュミエール28 摂食障害の治療 (2010)
  • Author(s): 永田利彦
  • Publisher: 中山書店
• [Book] 不安障害(パニック障害、社交不安障害)、摂食障害、パーソナリティ障害への対応 (2009)
  • Author(s): 永田利彦
  • Publisher: 中山書店
• [Book] 弁証法的行動療法 (2009)
  • Author(s): 永田利彦
  • Publisher: 診断と治療社