| Project/Area Number |
21591529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UKAI Satoshi 和歌山県立医科大学, 医学部, 准教授 (80324763)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOSAKI Kazuhiro 和歌山県立医科大学, 医学部, 教授 (40215984)
TSUJI Tomikimi 和歌山県立医科大学, 医学部, 講師 (10347586)
KOSE Asami 和歌山県立医科大学, 医学部, 助教 (10405425)
SHOYAMA Masaru 和歌山県立医科大学, 医学部, 助教 (70364081)
OKUMURA Masatoshi 和歌山県立医科大学, 医学部, 助教 (00464678)
YAMAMOTO Masahiro 和歌山県立医科大学, 医学部, 助教 (80423937)
UEYAMA Eiko 和歌山県立医科大学, 医学部, 助教 (40405444)
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| Research Collaborator |
TAKAHASHI Shun 和歌山県立医科大学, 医学部, 学内助教 (10508021)
HASHIMOTO Tadahiro 和歌山県立医科大学, 医学部, 学内助教 (00438277)
IWATANI Jun 和歌山県立医科大学, 医学部, 学内助教 (60458057)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 統合失調症 / 早期精神病 / アットリスク精神状態 / 2連発磁気刺激検査 / プレパルス抑制 / 経頭蓋磁気刺激 |
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| Research Abstract |
We examined recent onset schizophrenic patients and ultra high risk subjects by using two neurophysiological methods to evaluate dysfunction of GABA and NMDA systems which is assumed to be related with pathophysiology of schizophrenia. The resent onset schizophrenic patients showed dysfunction of GABA system, and this dysfunction was correlated with working memory disturbance. The results suggest GABA-modulating interventions in the early course of schizophrenia. The ultra high risk subjects showed dysfunction of NMDA system as well as schizophrenic patients. The results support the hypothesis that dysfunction of NMDA system is involved in decrease of gray matter volume even before clinical onset of schizophrenia.
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