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Elucidation of emotional regulation underlying metaplasticity during brain development

Research Project

Project/Area Number 21591530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

MATSUMOTO Machiko  北海道医療大学, 薬学部, 准教授 (70229574)

Co-Investigator(Kenkyū-buntansha) TOGASHI Hiroko  北海道医療大学, 薬学部, 教授 (20113590)
木村 真一  北海道医療大学, 薬学部, 講師 (90281287)
Co-Investigator(Renkei-kenkyūsha) KIMURA Shin-ichi  北海道医療大学, 薬学部, 講師 (90281287)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳機能発達 / 幼児期ストレス / 神経可塑性 / 臨界期 / ERK活性 / 恐怖記憶 / セロトニン / メタ可塑性 / 幼若期ストレス / 心的外傷後ストレス
Research Abstract

The present study demonstrated that early postnatal stress caused extinction deficit in adult rats, in which "critical period" exists during brain development. This extinction deficit appears to be associated with dysfunction of hippocampal CA1 field and/or medial prefrontal cortex(mPFC), because synaptic potentiation and ERK activation induced by extinction processes, in a brain specific manner, did not occur in juvenile stress model rats. This impaired synaptic plasticity and suppressed ERK activity, in addition to behavioral deficit were ameliorated by pretreatment with a NMDA receptor agonist D-cycloserine. These results suggest that the different phenotypes in adulthood result from neurodevelopmental perturbations of neural circuits of emotional regulation that elicited by early life stress.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009

All Journal Article (22 results) (of which Peer Reviewed: 20 results) Presentation (18 results) Book (2 results)

  • [Journal Article] Early postnatal stress alters extracellular s ignal-regulated kinase signaling in the corticoli mbic system modulating emotional circuitry in adult rats2011

    • Author(s)
      Ishikawa S, Saito Y, Yanagawa Y, Otani S, Hir aide S, Shimamura K, Matsumoto M, Togashi H.
    • Journal Title

      Eur J Neuroscience

      Volume: 35 Pages: 135-145

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin_<1A> receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress-in vivo and in vitro electrophysiological studies.2011

    • Author(s)
      Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A, Ishikawa S, Yamaguchi T, Yoshioka M, Shimamura K.
    • Journal Title

      Jpn. J. Neuropsychopharmacol

      Volume: 31 Pages: 9-15

    • NAID

      10029093883

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway2011

    • Author(s)
      Kamiyama H, Matsumoto M, Otani S, Kimura S, Shimamura K, Ishikawa S, Yanagawa Y, Togashi H.
    • Journal Title

      Neuroscience

      Volume: 177 Pages: 159-169

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenoceptor-mediated enhancement of interleukin-33 production by dendritic cells2011

    • Author(s)
      Yanagawa Y, Matsumoto M, Togashi H
    • Journal Title

      Brain Behav Immun

      Volume: 25 Pages: 1427-1433

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system modulating emotional circuitry in adult rats2011

    • Author(s)
      Ishikawa S, Saito Y, Yanagawa Y, Otani S, Hiraide S, Shimamura K, Matsumoto M, Togashi H
    • Journal Title

      Eur J Neurosci

      Volume: 35 Pages: 135-145

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E(2) enhances IL-33 production by dendritic cells2011

    • Author(s)
      Yanagawa Y, Suzuki M, Matsumoto M, Togashi H
    • Journal Title

      Immunol Lett

      Volume: 141 Pages: 55-60

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced dendritic cell antigen uptake via alpha2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline2010

    • Author(s)
      Yanagawa Y, Matsumoto M, Togashi H.
    • Journal Title

      J. Immunol

      Volume: 185 Pages: 5762-5768

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diazepam-induced increases of synaptic efficacy in the hippocampal-medial prefrontal cortex pathway are associated with its anxiolytic-like effect in rats2010

    • Author(s)
      Shikanai H, Izumi T, Matsumoto M, Togashi H, Yamaguchi T, Yoshida T, Yoshioka M.
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 114 Pages: 341-346

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT_<1A> receptor function in adult rats2010

    • Author(s)
      Matsuzaki H, Izumi T, Horinouchi T, Boku S, Inoue T, Yamaguchi T, Yoshida T, Matsumoto M, Togashi H, Miwa S, Koyama T, Yoshioka M.
    • Journal Title

      Psychopharmacology

      Volume: 214 Pages: 329-337

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early stress exposure impairs synaptic potentiation in the rat medial prefrontal cortex underlying contextual fear extinction2010

    • Author(s)
      Judo C, Matsumoto M, Yamazaki D, Hiraide S, Yanagawa Y, Kimura S, Shimamura K, Togashi H.
    • Journal Title

      Neuroscience

      Volume: 169 Pages: 1705-1714

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early stress exposure impairs synaptic potentiation in the rat medial prefrontal cortex underlying contextual fear extinction.2010

    • Author(s)
      Judo C, Matsumoto M, et al.
    • Journal Title

      Neuroscience

      Volume: 169 Pages: 1705-1714

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT(1A) receptor function in adult rats.2010

    • Author(s)
      Matsuzaki H, Izumi T, et al.
    • Journal Title

      Psychopharmacology(Berl)

      Volume: 214 Pages: 329-337

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced dendritic cell antigen-uptake via α_2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline.2010

    • Author(s)
      Yanagawa Y, Matsumoto M, et al
    • Journal Title

      Journal of Immunology.

      Volume: 15 Pages: 5762-5768

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress and neural circuit underlying emotional regulation2009

    • Author(s)
      Matsumoto M, Yoshioka M, Togashi H.
    • Journal Title

      International review of neurobiology

      Volume: 85 Pages: 95-107

    • Related Report
      2011 Final Research Report
  • [Journal Article] Corticotropin releasing factor enhances attentional function as assessed by the five-choice serial reaction time task in rats2009

    • Author(s)
      Ohmura Y, Yamaguchi T, Futami Y, Togashi H, Izumi T, Matsumoto M, Yoshid T, Yoshioka M.
    • Journal Title

      Behav Brain Res

      Volume: 198 Pages: 429-433

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress affects 5-HT_<1A> receptor function in the medial prefrontal cortex in adult rats2009

    • Author(s)
      Matsuzaki H, Izumi T, Matsumoto M, Togashi H, Yamaguchi T, Yoshida T, Watanabe M, Yoshioka M.
    • Journal Title

      Eur J Parmacol

      Volume: 615 Pages: 76-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible relationship between the stress-induced synaptic response and metaplasticity in the hippocampal CA1 field of freely moving rats2009

    • Author(s)
      Hirata R, Matsumoto M, Judo C, Yamaguchi T, Izumi T, Yoshioka M, Togashi H.
    • Journal Title

      Synapse

      Volume: 63 Pages: 549-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models2009

    • Author(s)
      Koseki H, Matsumoto M, Togashi H, Miura Y, Fukushima K, Yoshioka M.
    • Journal Title

      Synapse

      Volume: 63 Pages: 805-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models2009

    • Author(s)
      Koseki H., Matsumoto M., et al.
    • Journal Title

      Synapse 63

      Pages: 805-813

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible relationship between the stress-induced synaptic response and metaplasticity in the hippocampal CA1 field of freely moving rats.2009

    • Author(s)
      Hirata R, Matsumoto M, et al.
    • Journal Title

      Synapse 83

      Pages: 549-556

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats.2009

    • Author(s)
      Matsuzaki H, Izumi T, Matsumoto M, et al.
    • Journal Title

      European Journal of Pharmacology 615

      Pages: 76-82

    • NAID

      120001452160

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Matsumoto M, et al.
    • Journal Title

      Early postnatal stress and neural circuit underlying emotional regulation. International Review of Neurobiology(Academid Press)

      Pages: 95-107

    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス下の海馬シナプス応答に対する扁桃体の調節と幼若期ストレスの影響2011

    • Author(s)
      平出幸子、松本真知子、富樫廣子, 他
    • Organizer
      第41回日本神経精神薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 幼若期ストレスによる神経可塑的変化と精神疾患との関連性2011

    • Author(s)
      松本真知子、富樫廣子
    • Organizer
      第34回日本神経科学大会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 情動応答におけるToll-like receptor (TLR)の役割2011

    • Author(s)
      久保靖憲、柳川芳毅、松本眞知子、平出幸子、富樫廣子
    • Organizer
      第25回北海道薬物作用談話会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural plasticity and developmental stress2011

    • Author(s)
      松本真知子、富樫廣子
    • Organizer
      日・伊合同国際交流学術セミナー
    • Place of Presentation
      仙台
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] SHRSPの恐怖ストレスに対する皮質前頭前野シナプス応答2011

    • Author(s)
      平出幸子、松本真知子、柳川芳毅、山口拓、吉岡充弘、富樫廣子
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中枢神経系からみたSHR亜系と表現型の多様性」皮質-辺縁系シナプス応答とSHRSP/Ezo:第47回高血圧関連疾患モデル学会学術総会2011

    • Author(s)
      木村真一、松本真知子、富樫廣子、島村佳一:シンポジウム
    • Organizer
      第47回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system underlying emotional regulation in adult rats2010

    • Author(s)
      Ishikawa S, Matsumoto M, Togashi H., et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      SanDiego
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system underlying emotional regulation in adult rats2010

    • Author(s)
      Ishikawa S, Matsumoto M, et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      San Diego Convention center(U.S.A)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Context-dependent fear memory deficit accompanied with synaptic impairment in the rat medial prefrontal cortex2010

    • Author(s)
      Hiraide Y, Matsumoto M Togashi H., et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      SanDiego
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired fear extinction by exposure to early postnatal stress : evidence of altered neuronal processing in the rat hippocampus and medial prefrontal cortex network2010

    • Author(s)
      Saito Y, Matsumoto M, Togashi H., et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      SanDiego
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired fear extinction by exposure to early postnatal stress : evidence of altered neuronal processing in the rat hippocampus and medial prefrontal cortex network.2010

    • Author(s)
      Saito Y, Matsumoto M, et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      San Diego Convention center(U.S.A)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Context-dependent fear memory deficit accompanied with synaptic impairment in the rat medial prefrontal cortex.2010

    • Author(s)
      Hiraide Y, Matsumoto M, et al.
    • Organizer
      Society for Neuroscience 40^<th> annual meeting
    • Place of Presentation
      San Diego Convention center(U.S.A)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Early life stress and neural circuits underlying fear extinction in rats : translational approaches for psychotherapy of posttraumatic stress disorder2010

    • Author(s)
      Matsumoto M, Togashi H.
    • Organizer
      XXVII CINP World Congress
    • Place of Presentation
      香港
    • Year and Date
      2010-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Early life stress and neural circuits underlying fear extinction in rats : translational approaches for psychotherapy of posttraumatic stress Disorder2010

    • Author(s)
      Matsumoto M, Togashi H
    • Organizer
      XXVII CINP World Congress
    • Place of Presentation
      Hong-Kong Convention center(China)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ketamine-induced cortical dysfunction involved in dopaminergic and GABAergic mechanisms in rats2010

    • Author(s)
      Togashi H, Matsumoto M, et al.
    • Organizer
      XXVII CINP World Congress
    • Place of Presentation
      香港
    • Year and Date
      2010-06-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Ketamine-induced cortical dysfunction involved in dopaminergic and GABAergic mechanisms in rats2010

    • Author(s)
      Togashi H, Matsumoto M, et al.
    • Organizer
      XXVII CINP World Congress
    • Place of Presentation
      Hong-Kong Convention center(China)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Early postnatal stress alters fear extinction-associated prefrontal synaptic plasticity of adult rats2009

    • Author(s)
      松本真知子, 他
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early postnatal stress : Impact on neural circuits and relevance to psychophysiology2009

    • Author(s)
      松本真知子, 他
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      フランス(パリ)
    • Year and Date
      2009-06-28
    • Related Report
      2009 Annual Research Report
  • [Book] Early postnatal stress and emotional Vulnerability : Focus on neural circuits underlying fear memory in rats.(L. Sher and A. Vilens, eds.)2010

    • Author(s)
      Matsumoto M, Togashi H.
    • Publisher
      Nova Science Publishers
    • Related Report
      2011 Final Research Report
  • [Book] Neurobiology of Post-traumatic Stress Disorder : Early postnatal stress and emotional vulnerability : Focus on Neural circuits underlying fear memory in rats2010

    • Author(s)
      Matsumoto M, Togashi H
    • Publisher
      Nova Science Publishers, Inc.(New York)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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