Simultaneous fMRI-EEG-DTI Recording of MMN in Schizophrenia.
| Project/Area Number |
21591532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Juntendo University |
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Principal Investigator |
KIRINO Eiji 順天堂大学, 医学部, 准教授 (90276460)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | functional MRI / 事象関連電位 / 統合失調症 / 同時計測 / 拡散テンソルイメージング / 精神生理学 / ｆＭＲＩ / 拡散テンソルイメージ / LORETA / 拡散テンソル |
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| Research Abstract |
We simultaneously recorded Mismatch Negativity (MMN) during event-related functional MRI (fMRI) followed by diffusion tensor imaging (DTI) in healthy volunteers and schizophrenic patients. The correlation analysis on SPM revealed significant correlation between FA of the right uncinate fasciculus and BOLD activity in the left Insula. BOLD activity of the right anterior cingulate, the right corpus callosum and right insula significantly correlated with PANSS scores.
The dysfunction of Insula, the uncinate fasciculus and the corpus callosum, as well as the temporal lobe and the anterior cingulate gyrus, may specifically contribute to MMN aberration of schizophrenic patients and clinical manifestations reflecting their impaired MMN generation.
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Report
(6 results)
Research Products
(49 results)
