Longitudinal study of the relationship among psychiatric symptoms, social functioning and brain basis in individuals with an at-risk mental state(ARMS).

• Project/Area Number: 21591533
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Toho University
• Principal Investigator: MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589)
• Co-Investigator(Kenkyū-buntansha): MIZUMURA Sunao 東邦大学, 医学部, 准教授 (90287748) ; MORITA Keiko 東邦大学, 医学部, 助教 (20449242) ; NEMOTO Takahiro 東邦大学, 医学部, 准教授 (20296693) ; KATAGIRI Naoyuki 東邦大学, 医学部, 助教 (70459759)
• Co-Investigator(Renkei-kenkyūsha): HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳・神経 / 精神医学 / 統合失調症 / 早期発見 / 予防 / MRI / ARMS / 早期精神病 / 精神病

Research Abstract

To investigate the biological changes in the brain of individuals with an at-risk mental state, we compared the differences between ARMS subjects and healthy control subjects using MRI. The main findings were:
Reduction of the white matter integrity in corpus callosum and cingulum of ARMS subjects compared to healthy control subjects.
Volume reduction of the entorhinal cortex after a year of follow-up among ARMS subjects who developed psychosis compared to subjects those who did not.

Research Products

• [Journal Article] Cerebral blood flow changes in very-late-onset schizophrenia-like psychosis with catatonia before and after successful treatment : a case report (2011)
  • Author(s): Naohisa Tsujino, Takahiro Nemoto, Taiju Yamaguchi, Naoyuki Katagiri, Nao Tohgi, Ryu Ikeda ; Nobuyuki Shiraga, Sunao Mizumura, Masafumi Mizuno
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 600-613
  • Peer Reviewed
• [Journal Article] Lack of association between psychosis-like experiences and seeking help from professionals : A case-controlled study (2011)
  • Author(s): Hiroyuki Kobayashi, Takahiro Nemoto, Masaaki Murakami, Haruo Kashima, Masafumi Mizuno
  • Journal Title: Schizophrenia Research Volume: 132 Pages: 208-212
  • Peer Reviewed
• [Journal Article] Successful aging in individuals with schizophrenia dwelling in the community : A study on attitudes toward aging and preparing behavior for old age (2011)
  • Author(s): Niimura H, Nemoto T, Yamazawa R, Kobayashi H, Ryu Y, Sakuma K, Kashima H, Mizuno M
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 459-467
  • Peer Reviewed
• [Journal Article] Cerebral blood flow changes in very-late-onset schizophrenia-like psychosis with catatonia before and after successful treatment : a case report (2011)
  • Author(s): Naohisa Tsujino, Takahiro Nemoto, Taiju Yamaguchi, Naoyuki Katagiri, Nao Tohgi, Ryu Ikeda; Nobuyuki Shiraga, Sunao Mizumura, Masafumi Mizuno
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 600-603
  • Peer Reviewed
• [Journal Article] Reduced prefrontal cortex activation during divergent thinking in schizophrenia : A multi-channel NIRS study. (2010)
  • Author(s): Takeshi K., Nemoto T, Mizuno M, et al.
  • Journal Title: Prog Nuro-psychoph Volume: 34 Pages: 1327-1332
  • Peer Reviewed
• [Journal Article] Correlation between attenuated psychotic experiences and depressive symptoms among Japanese students. (2010)
  • Author(s): Kobayashi H, Mizuno M., et al.
  • Journal Title: Early Interv Psychia Volume: 4 Pages: 200-205
  • Peer Reviewed
• [Journal Article] Clinical and social determinants of a longer duration of untreated psychosis of schizophrenia in a Japanese population. (2010)
  • Author(s): Nishii H., Mizuno M., et al.
  • Journal Title: Early Interv Psychia Volume: 4 Pages: 182-188
  • Peer Reviewed
• [Journal Article] The effects of aripiprazole on insight and subjective experience in individuals with an at-risk mental state (2009)
  • Author(s): Hiroyuki Kobayashi
  • Journal Title: The Journal of Clinical Psychopharmacology 29 Pages: 421-425
  • Peer Reviewed
• [Journal Article] Subjective assessments of the quality of life, well-being and self-effficacy in patients with schizophrenia (2009)
  • Author(s): Bun Chino
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 521-528
  • Peer Reviewed
• [Journal Article] Cognitive training for divergent thinking in schizophrenia : A pilot study (2009)
  • Author(s): Takahiro Nemoto
  • Journal Title: Progress in Neuro-psychopharmacology and Biological Psychiatry 33 Pages: 1532-1536
  • Peer Reviewed
• [Presentation] Early psychosis in Asia : Insights from Japan (2012)
  • Author(s): Masafumi Mizuno
  • Organizer: International Conference on Early Psychosis in Asia Pacific
  • Place of Presentation: Hong Kong, China(招待講演)
  • Year and Date: 2012-01-14
• [Presentation] Fractional anisotropy reductions in ciugulum bundle and corpus callosum in at risk mental state (2012)
  • Author(s): Naoyuki Katagiri, Masaaki Hori, Takahiro Nemoto, Naohisa Tsujino, Keiko Morita, Junichi Saito, Keigo Shimoji, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
  • Organizer: 3rd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
• [Presentation] 教育講演精神疾患の早期発見・早期治療の進展 (2011)
  • Author(s): 水野雅文
  • Organizer: 第107回日本精神神経学会
  • Place of Presentation: ホテル・グラン・パシフィック・ルダイバ、ホテル日航東京(東京都)(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Early intervention development in Japan and its cultural background (2011)
  • Author(s): Masafumi Mizuno
  • Organizer: 3^<rd> World Congress of Asian Psychiatry
  • Place of Presentation: Melbourne, Australia(招待講演)
  • Year and Date: 2011-08-03
• [Presentation] Recognition and decisions regarding the treatment of early psychosis by Japanese psychiatrists. (2011)
  • Author(s): Naohisa Tsujino, Masafumi Mizuno, et al.
  • Organizer: 2nd Asian Society of schizophrenia Research
  • Place of Presentation: Seoul、Korea
• [Presentation] Management and rehabilitation in early psychosis intervention service.(invited lecture) (2011)
  • Author(s): Masafumi Mizuno
  • Organizer: SOPSI 2011
  • Place of Presentation: Roma、Italy
• [Presentation] At Risk Mental State(ARMS)における脳MRIの縦断的研究 (2010)
  • Author(s): 片桐直之
  • Organizer: 第5回日本統合失調症学会
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2010-03-27
• [Presentation] Longitudinal morphological changes of the brain in individuals with an at-risk mental state (ARMS). (2010)
  • Author(s): Naoyuki Katagiri, Masafumi Mizuno, et al.
  • Organizer: 7th International Conference on Early Psychosis
  • Place of Presentation: Amsterdam、The Netherlands
• [Presentation] Divergent thinking as a potential target for cognitive intervention in early psychosis (2010)
  • Author(s): Takahiro Nemoto, Masafumi Mizuno, et al.
  • Organizer: 2^<nd> Schizophrenia International Research Society Conference
  • Place of Presentation: Florence、Italy
• [Presentation] Examination regarding the effect of intervention to At Risk Mental State cases and the cases of false false-positive. (2010)
  • Author(s): Keiko Morita, Masafumi Mizuno, et al.
  • Organizer: 2^<nd> Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
• [Book] 精神病の早期診断実践ハンドブック (2011)
  • Author(s): 水野雅文監訳、小林啓之訳
  • Total Pages: 312
  • Publisher: 医学書院
• [Book] 精神科臨床倫理第4版 (2011)
  • Author(s): 水野雅文、藤井千代、村上雅昭、菅原道哉監訳
  • Total Pages: 721
  • Publisher: 星和書店
• [Book] サイコーシス・リスク シンドローム精神病の早期診断実践ハンドブック (2011)
  • Author(s): 水野雅文監訳、小林啓之訳
  • Total Pages: 312
  • Publisher: 医学書院
• [Book] 早期精神病の診断と治療 (2010)
  • Author(s): 水野雅文、鈴木道雄、岩田仲生(監訳)
  • Total Pages: 405
  • Publisher: 医学書院
• [Remarks]
  • URL: http://www.lab.toho-u.ac.jp/med/omori/mentalhealth/