| Project/Area Number |
21591533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMURA Sunao 東邦大学, 医学部, 准教授 (90287748)
MORITA Keiko 東邦大学, 医学部, 助教 (20449242)
NEMOTO Takahiro 東邦大学, 医学部, 准教授 (20296693)
KATAGIRI Naoyuki 東邦大学, 医学部, 助教 (70459759)
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳・神経 / 精神医学 / 統合失調症 / 早期発見 / 予防 / MRI / ARMS / 早期精神病 / 精神病 |
|---|
| Research Abstract |
To investigate the biological changes in the brain of individuals with an at-risk mental state, we compared the differences between ARMS subjects and healthy control subjects using MRI. The main findings were:
Reduction of the white matter integrity in corpus callosum and cingulum of ARMS subjects compared to healthy control subjects.
Volume reduction of the entorhinal cortex after a year of follow-up among ARMS subjects who developed psychosis compared to subjects those who did not.
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