Can inhaled oxygen be an MR contrast agent as a metabolic biosensor?
| Project/Area Number |
21591542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
TAMURA Hajime 東北大学, 大学院・医学系研究科, 教授 (20333817)
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| Co-Investigator(Kenkyū-buntansha) |
MUGIKURA Shunji 東北大学, 病院, 講師 (20375017)
MACHIDA Yoshio 東北大学, 大学院・医学系研究科, 教授 (30507083)
KINOSHITA Toshibumi 秋田県立脳血管研究センター, 放射線医学研究部, 部長 (70314599)
IBARAKI Masanobu 秋田県立脳血管研究センター, 放射線医学研究部, 研究員 (40360359)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生理学 / 脳神経疾患 / 医療福祉 / 酸素代謝 / 血流 / MRI / 緩和時間 / BOLD / 酸素 / 代謝 / 血流量 / BOLD効果 / 虚血 / 血液量 |
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| Research Abstract |
The effects of arterial pressure of oxygen(PaO2)on MRI T2* signal intensity, R1, and cerebral blood flow(CBF)were investigated to know if inhaled oxygen can be an MR contrast agent as a metabolic biosensor. The result showed that it is possible to measure changes in oxygen partial pressure of arterial blood and brain tissue noninvasively by measuring the change in longitudinal relaxation time. In addition, we found the possibility of estimating the amount of tissue oxygen metabolism by measuring simultaneously the end-tidal partial pressures of expired oxygen, the changes in the cerebral blood flow, and the changes in magnetic susceptibility effect.
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Report
(4 results)
Research Products
(22 results)
