| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
In accordance with the progression of multi-step hepatocarcinogenesis, the drainage vessels from the tumor changed from hepatic vein to hepatic sinusoids, and then portal vein, and this can be diagnosed by dynamic CT. There was an intensely significant correlation between OATP8 expression and signal intensity on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI. In addition, the expression of OATP8 was decreased from very early stage of hepatocarcinogenesis in accordance with the elevation of grade of malignancy of the tumors. Therefore, EOB-MRI was proved to be extremely useful in the diagnosis of early HCC
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