Analyses of regional brain biomechanics using fluctuation MR imaging and clinical application

• Project/Area Number: 21591550
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: MIYATI Tosiaki 金沢大学, 保健学系, 教授 (80324086)
• Co-Investigator(Kenkyū-buntansha): MASE Mitsuhito 名古屋市立大学, 医学研究科, 准教授 (60238920)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 医療・福祉 / 脳・神経 / 脳神経疾患 / 磁気共鳴画像(MRI) / バイオメカニクス

Research Abstract

We developed a fluctuation-magnetic resonance(MR) imaging, which was focused on the fluctuated water molecules in brain tissue due to the cerebral blood flow. We obtained regional biomechanical information of the brain using the fluctuation MR imaging, and applied that in clinical. We clarified that our method makes it possible to noninvasively assess the intracranial state, and to assist in the diagnosis of idiopathic normal-pressure hydrocephalus.

Research Products

• [Journal Article] Hemodynamic-independent analysis of water molecules fluctuation in brain using MRI (2012)
  • Author(s): Kan H, Miyati T, Mase M, Kasai H, Ohno N, Kawano M, Hara M, Shibamoto Y, Kitanaka A, Yorimitsu R
  • Journal Title: Medical Imaging and Information Sciences Volume: 27 Pages: 23-27
  • NAID: 130004876119
  • Peer Reviewed
• [Journal Article] Delta-ADC(apparent diffusion coefficient) analysis in patients with idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Osawa T, Mase M, Miyati T, Kan H, Demura K, Kasai K, Hara M, Shibamoto Y, Yamada K
  • Journal Title: Acta Neurochir Suppl Volume: 114 Pages: 197-200
• [Journal Article] Changes of fractional anisotropy and apparent diffusion coefficient in patients with idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Demura K, Mase M, Miyati T, Osawa T, Hattori M, Kasai H, Hara M, Shibamoto Y, Yamada K
  • Journal Title: Acta Neurochir Suppl Volume: 113 Pages: 29-32
• [Journal Article] Delta-ADC (apparent diffusion coefficient) analysis in patients with idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Osawa T
  • Journal Title: Acta Neurochir Suppl Volume: 114 Pages: 97-200
• [Journal Article] Idiopathic normal-pressure hydrocephalus : temporal changes in ADC during cardiac cycle (2011)
  • Author(s): Ohno N, Miyati T, Mase M, Osawa T, Kan H, Kasai H, Hara M, Shibamoto Y, Hayashi N, Gabata T, Matsui O
  • Journal Title: Radiology Volume: 261 Pages: 560-565
  • NAID: 120006370923
  • Peer Reviewed
• [Journal Article] Idiopathic normal pressure hydrocephalus : temporal changes in ADC during cardiac cycle (2011)
  • Author(s): Ohno N
  • Journal Title: Radiology Volume: 261 Issue: 2 Pages: 560-565
  • DOI: 10.1148/radiol.11101860
  • Peer Reviewed
• [Journal Article] Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Kan H
  • Journal Title: Proc.Intl.Soc.Mag.Reson.Med. Volume: 19 Pages: 4235-4235
• [Journal Article] Regional biomechanical property of intracranial tissue using dynamic diffusion MRI : a phantom study (2011)
  • Author(s): Kan H
  • Journal Title: Proc.Intl.Soc.Mag.Reson.Med. Volume: 19 Pages: 3978-3978
• [Journal Article] 心電同期拡散MRIによる脳のADC測定時の最適心時相 (2011)
  • Author(s): 菅博人
  • Journal Title: 日本放射線技術学会雑誌 Volume: 67 Pages: 661-672
  • Peer Reviewed
• [Journal Article] Imaging parameter effects in apparent diffusion coefficient determination of magnetic resonance imaging (2011)
  • Author(s): Akio Ogura
  • Journal Title: Eur J Radiol Volume: 77 Pages: 185-188
  • Peer Reviewed
• [Journal Article] Regional delta-diffusion analysis of the brain during cardiac cycle in idiopathic normal pressure hydrocephalus (2010)
  • Author(s): Ohno N
  • Journal Title: Proc.Intl.Soc.Mag.Reson.Med. Volume: 18 Pages: 2229-2229
• [Journal Article] Hemodynamic-independent analysis of fluctuated water molecules in brain using MRI (2010)
  • Author(s): Kan H
  • Journal Title: Int J CARS Suppl Volume: 5 Pages: 367-368
• [Journal Article] Imaging parameter effects in apparent diffusion coefficient determination of magnetic resonance imaging (2010)
  • Author(s): Akio Ogura
  • Journal Title: EUR J RADIOL (In press)
  • Peer Reviewed
• [Journal Article] Bulk motion independent analyses of water diffusion change in the brain during the cardiac cycle (2009)
  • Author(s): Nakamura T, Miyati T, Kasai H, Ohno N, Yamada M, Mase M, Hara M, Shibamoto Y, Suzuki Y, Ichikawa K
  • Journal Title: Radiol Phys Technol Volume: 2 Pages: 133-137
  • NAID: 120001591944
  • Peer Reviewed
• [Journal Article] Bulk motion independent analyses of water diffusion change in the brain during the cardiac cycle (2009)
  • Author(s): Tomoya Nakamura
  • Journal Title: Radiol Phys Technol 2 Pages: 133-137
  • Peer Reviewed
• [Presentation] Analyses of brain hydrodynamics and biomechanics using MRI (2012)
  • Author(s): Miyati T
  • Organizer: Invited special lecture in University of Miami
  • Place of Presentation: University of Miami(USA)
  • Year and Date: 2012-02-08
• [Presentation] Analyses of brain hydrodynamics and biomechanics using MRI (2012)
  • Author(s): Miyati T
  • Organizer: Special Lecture of University of Miami
  • Place of Presentation: Miami University (USA)(招待講演)
  • Year and Date: 2012-02-08
• [Presentation] Hemodynamically independent analysis of cerebral water fluctuation using diffusion and perfusion MRI (2011)
  • Author(s): Kitanaka A, Miyati T, Hayashi N, Gabata T, Matsui O, Alperin N, Takanaga M, Hamaguchi T, Ohno N, Kan H, Asano A
  • Organizer: 97th RSNA Meeting
  • Place of Presentation: McCormick Place(USA)
  • Year and Date: 2011-11-29
• [Presentation] Hemodynami cally independent analysis of cerebral water fluctuation using diffusion and perfusion MRI (2011)
  • Author(s): Kitanaka A
  • Organizer: 97th RSNA Meeting
  • Place of Presentation: McCormick Place Convention Center (USA)
  • Year and Date: 2011-11-29
• [Presentation] Temporal changes of the regional apparent diffusion coefficient of the brain during cardiac cycle in idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Mase M, Osawa T, Miyati T, Ohno N, Demura K
  • Organizer: Hydrocephalus 2011
  • Place of Presentation: Copenhagen University Hospital(Danmark)
  • Year and Date: 2011-09-06
• [Presentation] Temporal changes of the regional apparent diffusion coefficient of the brain during cardiac cycle in idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Mase M
  • Organizer: Hydrocephalus 2011
  • Place of Presentation: Copenhagen University Hospital (Danmark)
  • Year and Date: 2011-09-06
• [Presentation] Analyses of biomechanical properties of the brain using MRI (2011)
  • Author(s): Miyati T
  • Organizer: NeuroTalk 2011
  • Place of Presentation: Dalian World EXPO Center(China)
  • Year and Date: 2011-05-25
• [Presentation] Analyses of biomechanical properties of the brain using MRI (2011)
  • Author(s): Miyati T
  • Organizer: NeuroTalk 2011
  • Place of Presentation: Dalian World EXPO Center (China)(招待講演)
  • Year and Date: 2011-05-25
• [Presentation] Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Kan H, Miyati T, Ohno N, Mase M, Kasai H, Hara M, Shibamoto Y, Yamada K, Kawano M
  • Organizer: ISMRM 19th Scientific Meeting and Exhibition
  • Place of Presentation: Palais des Congres de Montreal Convention Center(Canada)
  • Year and Date: 2011-05-10
• [Presentation] Regional biomechanical property of intracranial tissue using dynamic diffusion MRI : a phantom study (2011)
  • Author(s): Kan H, Miyati T, Mase M, Hara M, Kawano M, Shibamot Y, Kasai H, Arai N, Kitanaka A, Yorimitsu R
  • Organizer: ISMRM 19th Scientific Meeting and Exhibition
  • Place of Presentation: Palais des Congres de Montreal Convention Center(Canada)
  • Year and Date: 2011-05-10
• [Presentation] Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Kan H
  • Organizer: ISMRM 18th Scientific Meeting and Exhibition
  • Place of Presentation: Palais des congres de Montreal (Canada)
  • Year and Date: 2011-05-10
• [Presentation] Regional biomechanical property of intracranial tissue using dynamic diffusion MRI : a phantom study (2011)
  • Author(s): Kan H
  • Organizer: ISMRM 18th Scientific Meeting and Exhibition
  • Place of Presentation: Palais des congres de Montreal (Canada)
  • Year and Date: 2011-05-10
• [Presentation] Analysis of diffusion tensor magnetic resonance images in patients with idiopathic normal pressure hydrocephalus before and after tap test (2010)
  • Author(s): Mase M, Demura K, Osawa T, Hattori M, Kasai H, Miyati T
  • Organizer: 14th International Conference On Intracranial Pressure And Brain Monitoring
  • Place of Presentation: University of Tuebingen(Germany)
  • Year and Date: 2010-09-13
• [Presentation] Analysis of diffusion tensor magnetic resonance images in patients with idiopathic normal pressure hydrocephalus before and after tap test (2010)
  • Author(s): Mase M
  • Organizer: 14th International Conference On Intracranial Pressure And Brain Monitoring
  • Place of Presentation: Tuebingen (Germany)
  • Year and Date: 2010-09-13
• [Presentation] Hemodynamic-independent analysis of fluctuated water molecules in brain using MRI (2010)
  • Author(s): Kan H, Miyati T, Alperin N, Lee SH, Kasai H, Mase M, Hara M, Shibamoto Y, Ohno N, Kawano M, Yamada K
  • Organizer: 24th International Congress and Exhibition(CARS 2010 Computer Assisted Radiology and Surgery)
  • Place of Presentation: University Medical Center(Switzeland)
  • Year and Date: 2010-06-23
• [Presentation] Hemodynamic-independent analysis of water molecules fluctuating in brain using MRI (2010)
  • Author(s): Kan H
  • Organizer: CARS 2010
  • Place of Presentation: Geneva (Switzeland)
  • Year and Date: 2010-06-23
• [Presentation] Changes of fractional anisotropy(FA) and apparent diffusion coefficient(ADC) in patients with idiopathic normal pressure hydrocephalus (2010)
  • Author(s): Mase M, Demura K, Osawa T, Hattori M, Kasai H, Miyati T, Yamada K
  • Organizer: 5th international hydrocephalus workshop
  • Place of Presentation: Creta Maris Convention & Golf Resort(Greece)
  • Year and Date: 2010-05-22
• [Presentation] Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in patients with idiopathic normal pressure hydrocephalus (2010)
  • Author(s): Mase M
  • Organizer: 5th international hydrocephalus workshop
  • Place of Presentation: Crete (Greece)
  • Year and Date: 2010-05-22
• [Presentation] Regional delta-diffusion analysis of the brain during cardiaccycle in idiopathic normal pressure hydrocephalus (2010)
  • Author(s): Ohno N
  • Organizer: ISMRM 17th Scientific Meeting and Exhibition
  • Place of Presentation: Stockholm (Sweden)
  • Year and Date: 2010-05-06
• [Presentation] Regional delta-diffusion analysis of the brain during cardiac cycle in idiopathic normal-pressure hydrocephalus (2009)
  • Author(s): Kan H, Miyati T, Mase M, Kasai H, Hara M, Shibamoto Y, Yamada K, Kawano M, Sakurai R
  • Organizer: 95th RSNA Meeting
  • Place of Presentation: McCormick Place(USA)
  • Year and Date: 2009-12-01
• [Presentation] Regional delta-diffusion analysis of the brain during cardiac cycle in idiopathic normal-pressure hydrocephalus (2009)
  • Author(s): Hirohito Kan
  • Organizer: 95th RSNA Meeting
  • Place of Presentation: McCormick Place (USA)
  • Year and Date: 2009-12-01
• [Remarks]
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/