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Measurement of cardiac energy efficiency using PET

Research Project

Project/Area Number 21591551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNagasaki University (2010-2011)
University of Fukui (2009)

Principal Investigator

KUDO Takashi  長崎大学, 大学院・医歯薬学総合研究科, 教授 (20330300)

Co-Investigator(Kenkyū-buntansha) NAKANO Akira  福井大学, 医学部, 助教 (20334815)
ARAKAWA Kenichirou  福井大学, 医学部, 助教 (80401967)
OKAZAWA Hidehiko  福井大学, 高エネルギー医学研究センター, 教授 (50360813)
Co-Investigator(Renkei-kenkyūsha) OKAZAWA Hidehiko  福井大学, 高エネルギー医学研究センター, 教授 (50360813)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords核医学(PETを含む) / 炭素11標識酢酸 / 心筋エネルギー効率 / ポジトロン断層撮影 / 心筋燃費 / エネルギー消費効率 / 心電図同期収集
Research Abstract

Using positron emission tomography(PET), especially C-11 acetate PET, we performed simultaneous measurement of myocardial perfusion, metabolism and cardiac function. We proved that the simultaneous measurement of these three parameters is possible. We can calculate the myocardial energy efficiency using this technique. The measurement of myocardial energy efficiency is useful tool for the evaluation of cardiac pathology such as mitochondrial cardiomyopathy, etc.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (19 results) Remarks (1 results)

  • [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson' s disease using[^<62> Cu] ATSM PET2011

    • Author(s)
      Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
    • Journal Title

      Nucl Med Biol

      Volume: 38 Pages: 945-51

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of indocyanine green retention rate at 15 minutes by correlated liver function parameters before hepatectomy2011

    • Author(s)
      Nanashima A, Abo T, Tobinaga S, Nonaka T, Fukuoka H, Hidaka S, Takeshita H, Sawai T, Yasutake T, Nagayasu T, Kudo T
    • Journal Title

      J Surg Res

      Volume: 16

    • NAID

      120006985073

    • URL

      http://naosite.lb.nagasaki-u.ac.jp/dspace/handle/10069/25521

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo functional brain imaging and a therapeutic trial of l-arginine in MELAS patients2011

    • Author(s)
      Yoneda M, Ikawa M, Arakawa K, Kudo T, Kimura H, Fujibayashi Y, Okazawa H
    • Journal Title

      Biochim Biophys Acta

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of^<62> Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease2011

    • Author(s)
      Isozaki M, Kiyono Y, Arai Y, Kudo T, Mori T, Maruyama R, Kikuta K, Okazawa H
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 1075-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo functional brain imaging and a therapeutic trial of 1-arginine in MELAS patients2011

    • Author(s)
      米田誠、荒川健一郎、工藤崇, 他
    • Journal Title

      Biochimica et Biophysica Acta (BBA) General Subjects

      Volume: (電子媒体) Issue: 5 Pages: 615-618

    • DOI

      10.1016/j.bbagen.2011.04.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET2011

    • Author(s)
      井川正道、岡沢秀彦、工藤崇, 他
    • Journal Title

      Nuclear Medicine and Bioligy

      Volume: 38 Issue: 7 Pages: 495-951

    • DOI

      10.1016/j.nucmedbio.2011.02.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease2011

    • Author(s)
      磯崎誠、工藤崇、岡沢秀彦, 他
    • Journal Title

      European Jounal of Nuclear Medicine and Molecular Imaging

      Volume: 38 Issue: 6 Pages: 1075-1082

    • DOI

      10.1007/s00259-011-1734-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of hepatic functional parameters with changes of functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization : a follow-up report2010

    • Author(s)
      Nanashima A, Tobinaga S, Abo T, Sumida Y, Araki M, Hayashi H, Sakamoto I, Kudo T, Takashita H, Hidaka S, Sawai T, Hatano K, Nagayasu T
    • Journal Title

      J Surg Res

      Volume: 164 Pages: 235-242

    • NAID

      120006984887

    • URL

      http://naosite.lb.nagasaki-u.ac.jp/dspace/handle/10069/24552

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Automatic labeling method for injectable^<15> O-oxygen using hemoglobin-containing liposome vesicles and its application for measurement of brain oxygen consumption by PET2010

    • Author(s)
      Tiwari VN, Kiyono Y, Kobayashi M, Mori T, Kudo T, Okazawa H, Fujibayashi Y
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 77-83

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiologic evaluation of MELASstrokes by serially quantified MRS and CASL perfusion images2010

    • Author(s)
      Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H, Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H
    • Journal Title

      Brain Dev

      Volume: 32 Pages: 143-149

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implication and prognosis of normal baseline cerebral blood flow with impaired vascular reserve in patients with major cerebral artery occlusive disease2010

    • Author(s)
      Isozaki M, Arai Y, Kudo T, Kiyono Y, Kobayashi M, Kubota T, Kikuta K, Okazawa H
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 371-377

    • NAID

      10027658838

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion. C-11 acetate kinetics revealed by positron emission tomography2010

    • Author(s)
      Arakawa K, Kudo T, Ikawa M, Morikawa N, Kawai Y, Sahashi K, Lee JD, Kuriyama M, Miyamori I, Okazawa H, Yoneda M
    • Journal Title

      Circ J

      Volume: 74 Pages: 2702-2711

    • NAID

      10027424699

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomy opathy and acute response to L-arginine infusion.C-11 acetate kinetics revealed by positron emission tomography.2010

    • Author(s)
      荒川健一郎, 工藤崇, 他
    • Journal Title

      Circulation Journal

      Volume: 74 Pages: 2702-2011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the calculation of the clearance rate constant(kmono) of[^<11> C] acetate using parametric kmono image for myocardial oxidative metabolism2009

    • Author(s)
      Hussain R, Kudo T, Tsujikawa T, Kobayashi M, Fujibayashi Y, Okazawa H
    • Journal Title

      Nucl Med Biol

      Volume: 36 Pages: 877-882

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow : a PET study with^<15> O-water2009

    • Author(s)
      Hussain R, Tsuchida T, Kudo T, Kobayashi M, Tsujikawa T, Kiyono Y, Fujibayashi Y, Okazawa H
    • Journal Title

      Ann Nucl Med

      Volume: 23 Pages: 717-723

    • NAID

      10026099251

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS2009

    • Author(s)
      Ikawa M, Okazawa H, Arakawa K, Kudo T, Kimura H, Fujibayashi Y, Kuriyama M, Yoneda M
    • Journal Title

      Mitochondrion

      Volume: 9 Pages: 144-148

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in early-phase tracer distribution in lung between^<11> C-acetate and 13N-ammonia2009

    • Author(s)
      Kudo T, Hata T, Kagawa S, Kishibe Y, Iwasaki J, Okazawa H
    • Journal Title

      Nucl Med Commun

      Volume: 30 Pages: 343-349

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiologic correlation between 62Cu-ATSM and 18F-FDG in lung cancer2009

    • Author(s)
      Lohith TG, Kudo T, Demura Y, Umeda Y, Kiyono Y, Fujibayashi Y, Okazawa H
    • Journal Title

      J Nucl Med

      Volume: 50 Pages: 1948-1953

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of microwave-based automated nucleophilic[^<18> F] fluorination systemand its application to the production of[^<18> F] flumazenil2009

    • Author(s)
      Mandap KS, Ido T, Kiyono Y, Kobayashi M, Lohith TG, Mori T, Kasamatsu S, Kudo T, Okazawa H, Fujibayashi Y
    • Journal Title

      Nucl Med Biol

      Volume: 36 Pages: 403-409

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional images reflect aggressiveness of endometrial carcinoma : estrogen receptor expression combined with^<18> F-FDG PET2009

    • Author(s)
      Tsujikawa T, Yoshida Y, Kudo T, Kiyono Y, Kurokawa T, Kobayashi M, Tsuchida T, Fujibayashi Y, Kotsuji F, Okazawa H
    • Journal Title

      J Nucl Med

      Volume: 50 Pages: 1598-1604

    • NAID

      120001658181

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia : the possible function in tumor acetyl-CoA/ acetate metabolism2009

    • Author(s)
      Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, Yonekura Y, Fujibayashi Y
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 821-827

    • NAID

      10025145355

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase : implications for the mechanism of acetate PET2009

    • Author(s)
      Yoshii Y, Waki A, Furukawa T, Kiyono Y, Mori T, Yoshii H, Kudo T, Okazawa H, Welch MJ, Fujibayashi Y
    • Journal Title

      Nucl Med Biol

      Volume: 36 Pages: 771-777

    • NAID

      120001871547

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of hemodynamic parameter measurement for cerebrovascular disease using positron emission tomography and^<15> O-labeled tracers2009

    • Author(s)
      Okazawa H, Kudo T
    • Journal Title

      Ann Nucl Med

      Volume: 23 Pages: 217-227

    • NAID

      10025135879

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 超短時間心電図同期Acetate PETによる心筋血流・代謝・機能同時測定の試み2011

    • Author(s)
      工藤崇
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 超短時間心電図同期Acetate PETによる心筋血流・代謝・機能同時測定の試み2011

    • Author(s)
      工藤崇
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Radiation risk associated with advanced diagnostic imaging : Preliminary report of comparative study on pediatric CT in Japan and Germany, and other studies2011

    • Author(s)
      Kudo T
    • Organizer
      Meeting of the Mainz-Nagasaki Radiation Research Initiative
    • Place of Presentation
      ドイツマインツ
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] PETの定量からSPECTの定量へ2011

    • Author(s)
      工藤崇
    • Organizer
      第21回日本心臓核医学会
    • Place of Presentation
      博多
    • Year and Date
      2011-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] PETの定量からSPECTの定量へ2011

    • Author(s)
      工藤崇
    • Organizer
      第21回日本心臓核医学会
    • Place of Presentation
      福岡国際会議場(博多)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Is ultra-short ECG gated acquisition of C-11 Acetate PET reliable for simultaneous MBF2011

    • Author(s)
      Kudo T
    • Organizer
      oxidative metabolism and myocardial function assessment? The SNM 58th Annual Meeting
    • Place of Presentation
      サンアントニオ、米国
    • Year and Date
      2011-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Is ultra-short ECG gated acquisition of C-11 Acetate PET reliable for simultaneous MBF, oxidative metabolism and myocardial function assessment?2011

    • Author(s)
      工藤崇
    • Organizer
      Society of Nuclear Medicine 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center(サンアントニオ、米国)
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] C-11酢酸PET超短時間心電図同期収集による心筋代謝・血流・心機能同時評価2011

    • Author(s)
      工藤崇
    • Organizer
      第70回日本医学放射線学会学術集会
    • Place of Presentation
      震災のためWeb開催
    • Related Report
      2011 Final Research Report
  • [Presentation] C-11酢酸PET超短時間心電図同期収集による心筋代謝・血流・心機能同時評価2011

    • Author(s)
      工藤崇
    • Organizer
      第70回日本医学放射線学会学術集会
    • Place of Presentation
      (震災のためWeb開催)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 急性期心筋梗塞におけるFDG/血流逆ミスマッチと酸素代謝の関係2010

    • Author(s)
      工藤崇
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      さいたま
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 急性期心筋梗塞におけるFDG/血流逆ミスマッチと酸素代謝の関係2010

    • Author(s)
      工藤崇、中野顯、岡沢秀彦, 他
    • Organizer
      第50回日本核医学会学術集会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] PETと心臓核医学~Known, Unknown, Misunderstood~2010

    • Author(s)
      工藤崇
    • Organizer
      福岡RIカンファレンス
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] PET・核医学の現在と展望2010

    • Author(s)
      工藤崇
    • Organizer
      長崎医学会
    • Place of Presentation
      佐世保
    • Year and Date
      2010-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 11C-acetate PETを用いた心筋梗塞発症早期の血流代謝機能の測定2010

    • Author(s)
      皿澤克彦, 工藤崇
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] C-11 Acetate PET超短時間心電図同期収集による心筋代謝・血流・機能同時イメージングの試み2010

    • Author(s)
      工藤崇
    • Organizer
      第5回日本分子イメージング学会学術集会
    • Place of Presentation
      大津
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] C-11 Acetate PET超短時間心電図同期収集による心筋代謝・血流・機能同時イメージングの試み2010

    • Author(s)
      工藤崇
    • Organizer
      第5回日本分子イメージング学会学術集会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血流・代謝・心機能同時評価Acetate PETを行うことができたAMIの一例2010

    • Author(s)
      工藤崇
    • Organizer
      第45回福岡RIカンファレンス
    • Place of Presentation
      福岡市 国際会議場
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム「次世代の腫瘍トレーサー」頭頚部腫瘍におけるCu-ATSMとFDGの対比検討2009

    • Author(s)
      工藤崇
    • Organizer
      第49回日本核医学会学術集会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] hANP treatment on acute myocardial infarction patients improves myocardial perfusion of risked myocardium : Measured with N-13 ammonia PET2009

    • Author(s)
      Kudo T
    • Organizer
      The SNM 56th Annual Meeting
    • Place of Presentation
      トロント、カナダ
    • Year and Date
      2009-06-15
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ等研究機関ホームページ(長崎大学原爆後障害医療研究施設)

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/index-sjis.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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