Synthesis of a novel imaging agent aimed for preclinical diagnosis

• Project/Area Number: 21591555
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MATSUSHIMA Yoshitaka 浜松医科大学, 医学部, 准教授 (20282816)
• Co-Investigator(Kenkyū-buntansha): KINO Jun 浜松医科大学, 医学部, 教務員 (40262810) ; MAGATA Yasuhiro 浜松医科大学, 光量子医学研究センター, 教授 (20209399)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: アルツハイマー / 有機合成 / PET

Research Abstract

In the course of pursuing a novel imaging agent especially for central nicotinic acetylcholine receptorα7 subtype, the compound was synthesized as a non-radioactive candidate from via(quinuclidin-3-yl) methanol with the reaction.

Research Products

• [Journal Article] Genetic susceptibility to lung cancer (2011)
  • Author(s): H. Sugimura, H. Tao, M. Suzuki, H. Mori, M. Tsuboi, S. Matsuura, M. Goto, K. Shinmura, T. Ozawa, F. Tanioka, N. Sato, Y. Matsushima, S. Kageyama, K. Funai, P.-H. Chou, T. Matsuda
  • Journal Title: Front. Biosci Pages: 1463-1477
• [Journal Article] Novel Concise Synthesis of(±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Opening Reaction (2011)
  • Author(s): Y. Matsushima and J. Kino
  • Journal Title: SYNTHESIS Pages: 1290-1294
• [Journal Article] Genetic susceptibility to lung cancer (2011)
  • Author(s): H.Sugimura, H.Tao, M.Suzuki, H.Mori, M.Tsuboi, S.Matsuura, M.Goto, K.Shimnura, T.Ozawa, F.Tanioka, N.Sato, Yoshitaka Matsushima, S.Kageyama, K.Funai, P.-H.Chou, T.Matsuda
  • Journal Title: Front.Biosci.(Schol.Ed.) Volume: S3 Issue: 1 Pages: 1463-1477
  • DOI: 10.2741/237
  • Peer Reviewed
• [Journal Article] Novel Concise Synthesis of (±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Ooenine Reaction. (2011)
  • Author(s): Yoshitaka Matsushima, J.Kino
  • Journal Title: SYNTHESIS Pages: 1290-1294
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of new imaging agent for central nicotinic acetylcholine receptorα7 subtype (2010)
  • Author(s): M. Ogawa, S. Nishiyama, H. Tsukada, K. Hatano, T. Fuchigami, H. Yamaguchi, Y. Matsushima, K. Ito, Y. Magata
  • Journal Title: Nucl. Med. Biol Volume: 37 Pages: 347-355
• [Journal Article] Synthesis of N-Bz-Protected D-Daunosamine and D-Ristosamine by Silica Gel Promoted Intramolecular Conjugate Addition of Trichloroacetimidates obtained from Osmundalactone and its Epimer (2010)
  • Author(s): Y. Matsushima and J. Kino
  • Journal Title: Eur. J. Org. Chem Pages: 2206-2210
• [Journal Article] Crystal Structures of Two Vancomycin Complexes with Phosphate and N-Acetyl-D-Ala. Structural Comparison between Low-Affinity and High-Affinity Ligand Complexes of Vancomycin (2010)
  • Author(s): T. Kikuchi, S. Karki, I. Fujisawa, Y. Matsushima, Y. Nitanai, K. Aoki
  • Journal Title: Bull. Chem. Soc. Jpn Volume: 83 Pages: 391-400
  • NAID: 10027173418
• [Journal Article] Synthesis and evaluation of new imaging agent for central nicotinic acetylcholine receptor α7 subtype. (2010)
  • Author(s): M.Ogawa, S.Nishiyama, H.Tsukada, K.Hatano, T.Fuchigami, H.Yamaguchi, Yoshitaka Matsushima, K.Ito, Y.Magata
  • Journal Title: Nucl.Med.Biol. Volume: 37 Pages: 347-355
  • Peer Reviewed
• [Journal Article] Synthesis of N-Bz-Protected D-Daunosamine and D-Ristosamine by Silica Gel Promoted Intramolecular Conjugate Addition of Trichloroacetimidates obtained from Osmundalactone and its Epimer (2010)
  • Author(s): Y.Matsushima, J.Kino
  • Journal Title: Eur.J.Org.Chem. Pages: 2206-2201
  • Peer Reviewed
• [Journal Article] Crystal Structures of Two Vancomycin Complexes with Phosphate and N-Acetyl-D-Ala. Structural Comparison between Low-Affinity and High-Affinity Ligand Complexes of Vancomycin (2010)
  • Author(s): T.Kikuchi, S.Karki, I.Fujisawa, Y.Matsushima, Y.Nitanai, K.Aoki
  • Journal Title: Bull.Chem.Soc.Jpn. 83 Pages: 391-400
  • NAID: 10027173418
  • Peer Reviewed
• [Presentation] カーバマートのヨード環化反応を用いたデオキシアミノ糖類の新規合成法の開発 (2012)
  • Author(s): 松島芳隆、記野順
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-24
• [Presentation] カーバマートのヨード環化反応を用いたデオキシアミノ糖類の新規合成法の開発 (2012)
  • Author(s): 松島芳隆、記野順
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 京都(京都女子大学)
  • Year and Date: 2012-03-24
• [Presentation] アミノクマリン系抗生物質ノボビオシンの構成デオキシ糖ノビオースの効率的合成 (2011)
  • Author(s): 松島芳隆、記野順
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-26
• [Presentation] アミノクマリン系抗生物質ノボビオシンの構成デオキシ糖ノビオースの効率的合成 (2011)
  • Author(s): 松島芳隆、記野順
  • Organizer: 日本農芸化学会大会(東日本大震災の影響で直前に中止となったが、発表自体は成立している。)
  • Place of Presentation: 京都(京都女子大学)
  • Year and Date: 2011-03-26
• [Presentation] トリクロロアセトイミダートの分子内共役付加反応を用いたデオキシアミノ糖の合成 (2010)
  • Author(s): 松島芳隆、記野順
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-29
• [Presentation] トリクロロアセトイミダートの分子内共役付加反応を用いたデオキシアミノ糖の合成 (2010)
  • Author(s): 松島芳隆, 記野順
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 東京 (東京大学駒場キャンパス)
  • Year and Date: 2010-03-29