Cerebral perfusion and metabolism study of brain ischemia using an integrated PET/ MR system.

• Project/Area Number: 21591561
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: SHIMOSEGAWA Eku 大阪大学, 大学院・医学系研究科, 准教授 (30370258)
• Co-Investigator(Kenkyū-buntansha): HATAZAWA Jun 大阪大学, 大学院・医学系研究科, 教授 (70198745)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 脳・神経 / 神経科学 / 放射線 / 脳神経 / PET / MRI

Research Abstract

We investigated quantitative cerebral perfusion and oxygen metabolism measurement and neuro-inflammation imaging in the rat model of brain ischemia using an original integrated PET/ MR system. By the simultaneous scanning of PET and MR images, PET findings were accurately comparable with the infarcted areas on MR T_2-weighted images.

Research Products

• [Journal Article] Simultaneous PET/ MR body imaging in rats : initial experiences with an integrated PET/ MRI scanner (2012)
  • Author(s): Tatsumi M, Yamamoto S, Imaizumi M, Watabe T, Kanai Y, Aoki M, Kato H, Shimosegawa E, Hatazawa J.
  • Journal Title: Ann Nucl Med
  • NAID: 10030788685
  • Peer Reviewed
• [Journal Article] Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/ MRI system (2012)
  • Author(s): Yamamoto S, Watabe T, Watabe H, Aoki M, Sugiyama E, Imaizumi M, Kanai Y, Shimosegawa E, Hatazawa J.
  • Journal Title: Phys Med Biol Volume: 57(2)
  • Peer Reviewed
• [Journal Article] Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MEI system (2012)
  • Author(s): Yamamoto S, Watabe T, Watabe H, Aoki M, Sugiyama E, Imaizumi M, Kanai Y, Shimosegawa E, Hatazawa J
  • Journal Title: Phys Med Biol Volume: 57-2 Issue: 2 Pages: N1-N13
  • DOI: 10.1088/0031-9155/57/2/n1
  • Peer Reviewed
• [Journal Article] Simultaneous PET/MR body imaging in rats : initial experiences with an integrated PET/MRI scanner (2012)
  • Author(s): Tatsumi M, Yamamoto S, Imaizumi M, et al
  • Journal Title: Ann Nucl Med. Volume: Feb 23(in press) Issue: 5 Pages: 444-449
  • DOI: 10.1007/s12149-012-0581-8
  • Peer Reviewed
• [Journal Article] Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/ MRI system (2011)
  • Author(s): Yamamoto S, Watabe H, Kanai Y, Aoki M, Sugiyama E, Watabe T, Imaizumi M, Shimosegawa E, Hatazawa J.
  • Journal Title: Phys Med Biol Volume: 56(13) Pages: 4147-4159
  • Peer Reviewed
• [Journal Article] Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/MRI system (2011)
  • Author(s): Yamamoto S, Watabe H, Kanai Y, Aoki M, Sugiyama E, Watabe T, Imaizumi M, Shimosegawa E, Hatazawa J
  • Journal Title: Phys Med Biol Volume: 56-13 Issue: 13 Pages: 4147-59
  • DOI: 10.1088/0031-9155/56/13/026
  • Peer Reviewed
• [Journal Article] Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer. (2011)
  • Author(s): Kobayashi S, et al.
  • Journal Title: J Surg Oncol Volume: 103(3) Pages: 223-229
  • Peer Reviewed
• [Journal Article] Design and performance from an integrated PET/ MRI system for small animals (2010)
  • Author(s): Yamamoto S, Imaizumi M, Kanai Y, Tatsumi M, Aoki M, Sugiyama E, Kawakami M, Shimosegawa E, Hatazawa J.
  • Journal Title: Ann Nucl Med Volume: 24(2) Pages: 89-98
  • NAID: 10026390630
  • Peer Reviewed
• [Journal Article] A compact and high sensitivity positron detector using dual-layer thin GSo scintillators for a small PET blood sampling system. (2010)
  • Author(s): Yamamoto S, et al.
  • Journal Title: Phys Med Biol Volume: 55(13) Pages: 3813-3826
  • Peer Reviewed
• [Journal Article] Development of a Si-PM-based high-resolution PET system for small animals. (2010)
  • Author(s): Yamamoto S, et al.
  • Journal Title: Phys Med Biol Volume: 55(19) Pages: 5817-5831
  • Peer Reviewed
• [Journal Article] Global cerebral hypoperfusion in preclinical stage of idiopathic normal pressure hydrocephalus. (2010)
  • Author(s): Takaya M, et al.
  • Journal Title: J Neurol Sci Volume: 298(1-2) Pages: 35-41
  • Peer Reviewed
• [Journal Article] Design and performance from an integrated PET/MRI system for small animals. (2010)
  • Author(s): Yamamoto S, et al.
  • Journal Title: Ann Nucl Med. 24 Pages: 89-98
  • Peer Reviewed
• [Journal Article] Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET : a validation study in ex vivo rat brain (2009)
  • Author(s): Imaizumi M, Yamamoto S, Kawakami M, Aoki M, Sugiyama E, Kanai Y, Shimosegawa E, Hatazawa J.
  • Journal Title: Jpn J Radiol Volume: 27(6) Pages: 252-256
  • NAID: 50007286615
  • Peer Reviewed
• [Journal Article] Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber based PET : a validation study in ex vivo rat brain (2009)
  • Author(s): Imaizumi M, et al.
  • Journal Title: Jpn J Radiol 27 Pages: 252-256
  • Peer Reviewed
• [Presentation] PET/MRI一体型装置によるラット脳血流定量評価 (2011)
  • Author(s): 渡部直史、下瀬川恵久、渡部浩司, 他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2011-10-28
• [Presentation] Development of a flexible optical fiber based high resolution integrated PET/MRI system : iPET/MRI II (2011)
  • Author(s): Yamamoto S, Aoki M, SugiyamaE, et al
  • Organizer: Society of Nuclear Medicine's 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center, U.S.A.
  • Year and Date: 2011-06-07
• [Presentation] Imaging of cerebral oxygen metabolism in the rat brain : An integrated PET/MRI study with ^<15>O-labelled gas (2011)
  • Author(s): Watabe T, Shimosegawa E, Kanai Y, et al
  • Organizer: Society of Nuclear Medicine's 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center, U.S.A.
  • Year and Date: 2011-06-06
• [Presentation] PET/ MRI一体型装置によるラット脳血流定量評価 (2011)
  • Author(s): 渡部直史、下瀬川恵久、渡部浩司、他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば市、つくば国際会議場
• [Presentation] Development of a flexible optical fiber based high resolution integrated PET/ MRI system : iPET/ MRI II (2011)
  • Author(s): Yamamoto S, Aoki M, Sugiyama E, Watabe H, Watabe T, Kanai Y, Imaizumi M, Shimosegawa E, Hatazawa J.
  • Organizer: Society of Nuclear Medicine' s 58th Annual Meeting
  • Place of Presentation: San Antonio, Texas, USA
• [Presentation] Imaging of cerebral oxygen metabolism in the rat brain : An integrated PET/ MRI study with^15<O>-labelled gas (2011)
  • Author(s): Watabe T, Shimosegawa E, Kanai Y, Watabe H, Imaizumi M, Yamamoto S, Kato H, Tatsumi M, Hatazawa J.
  • Organizer: Society of Nuclear Medicine' s 58th Annual Meeting
  • Place of Presentation: San Antonio, Texas, USA
• [Presentation] Validation of CT attenuation correction for the quantitative SPECT-CBF image reconstruction : A comparative study with O-15 water PET. (2010)
  • Author(s): Shimosegawa E, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] Validation of zero and 1% residual cerebral blood flow measurement by means of SPECT and Tc-99m pertechnetate solution : A phantom study. (2010)
  • Author(s): Fujino K, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] Cerebral glucose metabolism immediately after traumatic brain injury in rats : An integrated PET/MRI study. (2010)
  • Author(s): Imaizumi M, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] Astrocyte specific energy metabolism in humans studied with C-11 acetate and PET : A comparison with F-18 fluoro-deoxy-glucose (FDG). (2010)
  • Author(s): Hatazawa J, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] Pharmacokinetic study of C-11 donepezil in rats measured by planar positron imaging system : A correlation between micro-dose and therapeutic dose distribution. (2010)
  • Author(s): Shimosegawa E, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, Utah, USA
• [Presentation] Integrated PET/ MRI(iPET/ MRI) for small animals : Performance characteristics and initial experiences (2009)
  • Author(s): Shimosegawa E, Yamamoto S, Imaizumi M, Kanai Y, Tatsumi M, Masaaki Aoki, Sugiyama E, Hatazawa J
  • Place of Presentation: Barcelona, Spain
• [Presentation] Simultaneous 11C-methionine (MET) PET and contrast-enhanced (CE) MR rat imaging with an integrated PETIMRI system : Initial experience (2009)
  • Author(s): Tatsumi M, et al.
  • Organizer: Society of Nuclear Medicine's 56th Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] Development of an integrated PET/MRI (iPET/MRI) system for small animals (2009)
  • Author(s): Yamamoto S, et al.
  • Organizer: Society of Nuclear Medicine's 56th Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] In vivo small animal simultaneous measurements using integrated PET/MRI (iPET/MRI) system with ^<18>F-FDG (2009)
  • Author(s): Imaizumi M, et al.
  • Organizer: Society of Nuclear Medicine's 56th Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] Integrated PET/MRI (iPET/MRI) for small animals : Performance characteristics and initial experiences (2009)
  • Author(s): Shimosegawa E, et al.
  • Organizer: European Association of Nuclear Medicine 2009
  • Place of Presentation: Barcelona, Spain
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/tracer/index-jp.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/tracer/index-jp.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/tracer/index-jp.htm