Application of SPECT/CT system in diagnosis of ischemic heart disease

• Project/Area Number: 21591566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: TOMIGUCHI Seiji 熊本大学, 大学院・生命科学研究部, 教授 (20172182)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Akihiro 熊本大学, 生命資源研究・支援センター, 准教授 (20161903) ; SHIRAISHI Shinya 熊本大学, 助教 (50433008)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 虚血性心疾患 / SPECT/CT / 減弱補正 / 散乱線補正 / 分解能補正 / 空間分解能補正 / 拡張期変換画像 / SPECT / CT

Research Abstract

Fundamental and clinical usefulness of SPECT/CT in the diagnosis of ischemic heart disease was evaluated. Attenuation, scatter and resolution correction for myocardial perfusion SPECT were performed by using CT image. In phantom study, uniformity, defect contrast and count quantification improved with all corrections. In clinical study, sensitivity and specificity in the diagnosis of ischemic heart disease improved with all corrections except decrease in the specificity of LAD territory. However, improvement in the specificity was compensated by using a converted endodiastolic(CED) image. Furthermore,% myocardial radioactivity to the injected dose was considered to be the good index to evaluate the myocardial flow reserve.

Research Products

• [Journal Article] SPECT, PETの臨床における位置ずけ (2011)
  • Author(s): 冨口靜二
  • Journal Title: インナービジョン Volume: 26巻 Pages: 64-67
• [Journal Article] SPECTによる心筋虚血と梗塞評価 (2011)
  • Author(s): 冨口靜二
  • Journal Title: 心CT Volume: 8巻 Pages: 72-78
• [Journal Article] Clinical usefulness of a collimator distance dependent resolution recovery in myocardial perfusion SPECT : a clinical report from a single institute (2011)
  • Author(s): Tashiro K, Tomiguchi S, Shiraishi S, Yoshida M, Sakaguchi F, Yamashita Y
  • Volume: 25巻
  • Pages: 133-137
  • NAID: 10028999190
  • Peer Reviewed
• [Journal Article] SPECTによる心筋虚血と梗塞評価 (2011)
  • Author(s): 冨口静二
  • Journal Title: 心CT Volume: 8 Pages: 72-78
• [Journal Article] SPECT, PETの臨床における位置ずけ (2011)
  • Author(s): 冨口静二
  • Journal Title: インナービジョン Volume: 26 Pages: 64-67
• [Journal Article] Clinical usefulness of a collimator distance dependent resolution recovery in myocardial perfusion SPECT : a clinical report from a single institute. (2011)
  • Author(s): Tashiro Kuniyuki
  • Journal Title: Ann Nucl Med Volume: 25 Pages: 133-137
  • Peer Reviewed
• [Journal Article] SPECT-CT装置の画像再構成 (2010)
  • Author(s): 冨口靜二
  • Journal Title: PET journal Volume: 9巻 Pages: 16-18
• [Journal Article] 心筋SPECT検査におけるCDR補正とESSE法による散乱線補正の有用性 (2010)
  • Author(s): 中村裕也、冨口靜二、勝田昇
  • Journal Title: 日本放射線技術学会雑誌 Volume: 66巻 Pages: 609-617
  • Peer Reviewed
• [Journal Article] SPECT-CT装置の画像再構成 (2010)
  • Author(s): 冨口静二
  • Journal Title: PET journal Volume: 9 Pages: 16-18
• [Journal Article] 心筋SPECT検査におけるCDR補正とESSE法による散乱線補正の有用性 (2010)
  • Author(s): 中村祐也
  • Journal Title: 日本放射線技術学会雑誌(掲載確定)
  • Peer Reviewed
• [Journal Article] 補正組み込み型OS-EM法の再構成条件が左室内腔容積算出に及ぼす影響 (2009)
  • Author(s): 中村裕也、冨口靜二、勝田昇、鷹本慶子
  • Journal Title: 日本放射線技術学会雑誌 Volume: 65巻 Pages: 931-937
  • NAID: 10025977116
  • Peer Reviewed
• [Journal Article] 補正組み込み型OS-EM法の再構成条件が左室内腔容積算出に及ぼす影響 (2009)
  • Author(s): 中村祐也
  • Journal Title: 日本放射線技術学会雑誌 65 Pages: 931-937
  • Peer Reviewed
• [Presentation] New method for making 3D-fused image of SPECT-MPI with coronary CT angiography (2011)
  • Author(s): Tanaka Masayuki, Tomiguchi Seiji
  • Organizer: EANM 2011 Annual Congress
  • Place of Presentation: ICC & NIA Birmingham(united kingdom)
  • Year and Date: 2011-10-19
• [Presentation] New method for making 3D-fused image of SPECT-MPI with coronary CT angiography (2011)
  • Author(s): Tanaka Masayuki
  • Organizer: EANM 2011 Annual Congress
  • Place of Presentation: ICC&NIA Birmingham
  • Year and Date: 2011-10-19
• [Presentation] Tl^<201>心筋SPECT拡張末期変換投影像による心筋虚血の評価 (2010)
  • Author(s): 冨口靜二
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(大宮)
  • Year and Date: 2010-11-12
• [Presentation] ^<201>Tl心筋SPECT拡張末期変換投影像による心筋虚血の評価 (2010)
  • Author(s): 冨口静二
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-11-12
• [Presentation] Computerized method for converting ECG-gated projection data to end-diastolic projection data on 201Tl myocardial perfusion SPECT (2010)
  • Author(s): Ujihara Shintaro, Tomiguchi Seiji, Tashiro Kuniyuki, Yoshida Moriktsu, Shiraishi Shinya, Sakaguchi Fumi, Yasuyuki Yamashita, Katsuragawa Shigehiko
  • Organizer: EANM 2010 Annual Congress
  • Place of Presentation: Austria center Vienna(Austria)
  • Year and Date: 2010-10-11
• [Presentation] Computerized method for converting ECG-gated projection data to end-diastolic projection data on 201Tl myocardial perfusion SPECT. (2010)
  • Author(s): Ujihara Shintaro
  • Organizer: EANM 2010 Annual Congress
  • Place of Presentation: Austria Center Vienna, Austria
  • Year and Date: 2010-10-11
• [Presentation] 心臓の画像診断 (2009)
  • Author(s): 冨口靜二
  • Organizer: 第29回日本核医学技術学会学術大会
  • Place of Presentation: 旭川市民文化会館(旭川)
  • Year and Date: 2009-10-03
• [Presentation] 心臓の画像診断 (2009)
  • Author(s): 冨口静二
  • Organizer: 第29回日本核医学技術学会学術大会
  • Place of Presentation: 旭川市民文化会館(北海道)
  • Year and Date: 2009-10-03