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Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation with special attention to shunt volume in patients with pulmonary fibrosis using phase contrast MRI.

Research Project

Project/Area Number 21591570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

MURAYAMA Sadayuki  琉球大学, 大学院・医学研究科, 教授 (60239548)

Co-Investigator(Kenkyū-buntansha) KAKINOHANA Yasumasa  琉球大学, 大学院・医学研究科, 助教 (20185713)
KAMIYA Hisashi  琉球大学, 大学院・医学研究科, 助教 (60363678)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺高血圧 / MRI / Velocity-encoded cine MRI / 肺動脈血流 / cine MRA / 肺線維症 / 肺動脈血流量
Research Abstract

Using PC-MRI, we calculated various indexes of the pulmonary blood flow of the patients that pulmonary hypertension should have been suspected and examined correlation with the echocardiographic tricuspid gradient. As a result, an average area of the pulmonary artery truncus, minimum area, and a maximal area a were well correlated with tricuspid gradient. It was minimum area to have been the strongest in a correlation ;(coefficient of correlation 0. 772 ; p=0. 001). Secondly, an aortic and pulmonary arterial flow by PC-MRI for normal volunteers and patients with interstitial pneumonia were calculated both during free breathing and respiratory breath-holding. Both flow significantly decreased in normal volunteers and patients. However, in patients, no significant reduction under the breath-holding nor increase of bronchopulmonary shunt were observed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Estimation of pulmonary vascular resistance in patients with pulmonary fibrosis by phase-contrast magnetic resonance imaging2011

    • Author(s)
      Yuichiro Ayukawa
    • Journal Title

      Japanese Journal of Radiology

      Volume: 29 Pages: 563-569

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] phase-contrast MRIを用いた肺高血圧症の評価-心臓超音波検査による三尖弁圧較差との相関の検討-2012

    • Author(s)
      椿本真穂
    • Organizer
      第4回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      滋賀県琵琶湖ホテル
    • Year and Date
      2012-02-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phase-contrast MRIを用いた肺高血圧症の評価-心臓超音波検査による三尖弁圧較差との相関の検討-2012

    • Author(s)
      椿本真穂、土屋奈々絵、鮎川雄一郎、村山貞之、安隆則
    • Organizer
      第4回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      滋賀県,ピアザ淡海、琵琶湖ホテル
    • Related Report
      2011 Final Research Report
  • [Presentation] Phase-contrast MRIによる肺血流評価と肺動脈圧の関連性2011

    • Author(s)
      土屋奈々絵、鮎川雄一郎、村山貞之、安隆則
    • Organizer
      第112回沖縄県医師会医学会総会
    • Place of Presentation
      沖縄県,沖縄県医師会館
    • Year and Date
      2011-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation in patients with pulmonary fibrosis in relation to breathing methods using phase contrast MRI2011

    • Author(s)
      土屋奈々絵
    • Organizer
      5^<th> International Workshop of Pulmonary Functional Imaging
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Year and Date
      2011-01-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of Hemodynamic Changes in Pulmonary and Systemic Arterial Circulation in Patients with Pulmonary Fibrosis in Relation to Breathing Methods Using. Phase Contrast MRI2011

    • Author(s)
      Nanae Tsuchiya, Yuichiro Ayukawa, Sadayuki Murayama
    • Organizer
      Joint Meeting combining The 3rd meeting of the Japanese Society of Pulmonary Functional Imaging and 5th International Workshop for Pulmonary Functional Imaging
    • Place of Presentation
      兵庫県、兵庫県淡路夢舞台国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] PHASE CONTRAST MRIによる肺線維症患者の肺動脈圧の評価2010

    • Author(s)
      鮎川雄一郎
    • Organizer
      第12回沖縄血管病態研究会
    • Place of Presentation
      ラグナガーデンホテル(沖縄県)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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