Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation with special attention to shunt volume in patients with pulmonary fibrosis using phase contrast MRI.

• Project/Area Number: 21591570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of the Ryukyus
• Principal Investigator: MURAYAMA Sadayuki 琉球大学, 大学院・医学研究科, 教授 (60239548)
• Co-Investigator(Kenkyū-buntansha): KAKINOHANA Yasumasa 琉球大学, 大学院・医学研究科, 助教 (20185713) ; KAMIYA Hisashi 琉球大学, 大学院・医学研究科, 助教 (60363678)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺高血圧 / MRI / Velocity-encoded cine MRI / 肺動脈血流 / cine MRA / 肺線維症 / 肺動脈血流量

Research Abstract

Using PC-MRI, we calculated various indexes of the pulmonary blood flow of the patients that pulmonary hypertension should have been suspected and examined correlation with the echocardiographic tricuspid gradient. As a result, an average area of the pulmonary artery truncus, minimum area, and a maximal area a were well correlated with tricuspid gradient. It was minimum area to have been the strongest in a correlation ;(coefficient of correlation 0. 772 ; p=0. 001). Secondly, an aortic and pulmonary arterial flow by PC-MRI for normal volunteers and patients with interstitial pneumonia were calculated both during free breathing and respiratory breath-holding. Both flow significantly decreased in normal volunteers and patients. However, in patients, no significant reduction under the breath-holding nor increase of bronchopulmonary shunt were observed.

Research Products

• [Journal Article] Estimation of pulmonary vascular resistance in patients with pulmonary fibrosis by phase-contrast magnetic resonance imaging (2011)
  • Author(s): Yuichiro Ayukawa
  • Journal Title: Japanese Journal of Radiology Volume: 29 Pages: 563-569
  • Peer Reviewed
• [Presentation] phase-contrast MRIを用いた肺高血圧症の評価-心臓超音波検査による三尖弁圧較差との相関の検討- (2012)
  • Author(s): 椿本真穂
  • Organizer: 第4回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 滋賀県琵琶湖ホテル
  • Year and Date: 2012-02-10
• [Presentation] Phase-contrast MRIを用いた肺高血圧症の評価-心臓超音波検査による三尖弁圧較差との相関の検討- (2012)
  • Author(s): 椿本真穂、土屋奈々絵、鮎川雄一郎、村山貞之、安隆則
  • Organizer: 第4回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 滋賀県,ピアザ淡海、琵琶湖ホテル
• [Presentation] Phase-contrast MRIによる肺血流評価と肺動脈圧の関連性 (2011)
  • Author(s): 土屋奈々絵、鮎川雄一郎、村山貞之、安隆則
  • Organizer: 第112回沖縄県医師会医学会総会
  • Place of Presentation: 沖縄県,沖縄県医師会館
  • Year and Date: 2011-06-12
• [Presentation] Evaluation of hemodynamic changes in pulmonary and systemic arterial circulation in patients with pulmonary fibrosis in relation to breathing methods using phase contrast MRI (2011)
  • Author(s): 土屋奈々絵
  • Organizer: 5^<th> International Workshop of Pulmonary Functional Imaging
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
  • Year and Date: 2011-01-29
• [Presentation] Evaluation of Hemodynamic Changes in Pulmonary and Systemic Arterial Circulation in Patients with Pulmonary Fibrosis in Relation to Breathing Methods Using. Phase Contrast MRI (2011)
  • Author(s): Nanae Tsuchiya, Yuichiro Ayukawa, Sadayuki Murayama
  • Organizer: Joint Meeting combining The 3rd meeting of the Japanese Society of Pulmonary Functional Imaging and 5th International Workshop for Pulmonary Functional Imaging
  • Place of Presentation: 兵庫県、兵庫県淡路夢舞台国際会議場
• [Presentation] PHASE CONTRAST MRIによる肺線維症患者の肺動脈圧の評価 (2010)
  • Author(s): 鮎川雄一郎
  • Organizer: 第12回沖縄血管病態研究会
  • Place of Presentation: ラグナガーデンホテル(沖縄県)
  • Year and Date: 2010-11-12