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MRI位相差情報を用いた無侵襲脳血流定量計測法の開発と臨床応用

Research Project

Project/Area Number 21591575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

工藤 與亮  Iwate Medical University, 医学部, 講師 (10374232)

Co-Investigator(Kenkyū-buntansha) 佐々木 真理  岩手医科大学, 医学部, 教授 (80205864)
小笠原 邦昭  岩手医科大学, 医学部, 教授 (00305989)
寺江 聡  北海道大学, 大学病院, 准教授 (40240634)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords核磁気共鳴画像 / 脳血流 / 位相画像
Research Abstract

本研究の目的は超高磁場MRI装置による位相画像を用いて、非侵襲的で定量的な脳脊髄血流解析法を開発・臨床応用することである。
既存の複数の3T-MRI装置(GE社、Philips社)を用いた磁化率強調画像の位相画像から酸素飽和度を算出するプログラムを作成し、酸素飽和度の定量値算出及び脳血流変化のマップ化を行った。さらに、酸素飽和度から酸素摂取率(OEF)を算出するプログラムを作成し、呼吸負荷や薬物負荷によりOEFが有意に変化することが確認された。これらの研究成果は国際学会での発表を行い、論文投稿中である。また、内頚動脈狭窄患者でも脳の位相画像を撮像し、安静時でもOEFの上昇が観察されたが、さらにOEFマップ作成のアルゴリズム改良を行っている。今までは2回のMRI撮像を行って位相変化から酸素飽和度やOEFの変化率を算出できていたが、それを1回のMRI撮像で絶対値として値を算出できるようにプログラム・アルゴリズムを改変中である。患者群ではDiamox負荷での経時的変化の撮像も行っており、PETでのOEFマップとの比較や、MRIのASL法による脳血流マップとの比較を行っている。
また、同時に脳血流解析の基礎的検討として数値ファントムを開発し、解析プログラムの精度検証を行っているが、市販ソフトウェアでの解析結果がまとまったので論文作成中である。さらに、各市販ソフトウェアメーカへの結果のフィードバックも行っている。

Report

(2 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (9 results)

  • [Journal Article] Non-Invasive Measurement of Oxygen Saturation in the Spinal vein using SWI : Quantitative Evaluation under Conditions of Physiological and Caffeine Load2011

    • Author(s)
      Fujima N, Kudo K, Terae S, Ishizaka K, Yazu R, Zaitsu Y, Tha KK, Yoshida K, Tsukahara A, Haacke EM, Sasaki M, Shirato H
    • Journal Title

      Neuroimage

      Volume: 54 Pages: 344-349

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility of Tmax to Tracer Delay on Perfusion Analysis : Quantitative Evaluation of Various Deconvolution Algorithms Using Digital Phantoms2010

    • Author(s)
      Kudo K, Sasaki M, Ostergaard L, Christensen S, Uwano I, Suzuki M, Ogasawara K, Shirato H, Ogawa A
    • Journal Title

      JCBFM

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility-Weighted Imaging of Cerebral Fat Embolism2010

    • Author(s)
      Zaitsu Y, Terae S, Kudo K, Tha KK, Hayakawa M, Fujima N, Yoshida D, Tsukahara A, Shirato H
    • Journal Title

      J Comput Assist Tomogr

      Volume: 34 Pages: 107-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain Temperature Measured by Proton Magnetic Resonance Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy2010

    • Author(s)
      Murakamki T, Ogasawara K, Yoshioka Y, Ishigaki D, Sasaki M, Kudo K, Aso K, Nishimoto H, Kobayashi M, Yoshida K, Ogawa A
    • Journal Title

      Radiology

      Volume: 256 Pages: 924-931

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of infarct volume and neurologic outcome by using automated multiparametric perfusion-weighted magnetic resonance imaging in a primate model of permanent middle cerebral artery occlusion2010

    • Author(s)
      Sasaki M, Kudo K, Honjo K, Hu JQ, Wang HB, Shintaku K
    • Journal Title

      JCBFM

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution diffusion tensor imaging for the detection of diffusion a bnormalities in the trigeminal nerves of patients with trigeminal neuralgia caused by neurovascular compression.2010

    • Author(s)
      Fujiwara S, Sasaki M, Wada T, Kudo K, Hirooka R, Ishigaki D, Nishikawa Y, Ono A, Yamaguchi M, Ogasawara K
    • Journal Title

      J Neuroimaging

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility-Weighted Imaging and Magnetic Resonance Angiography during Migraine Attack : A Case Report2010

    • Author(s)
      Shimoda Y, Kudo K, Kuroda S, Zaitsu Y, Fujima N, Terae S, Sasaki M, Houkin K
    • Journal Title

      Magnetic Resonance in Medical Science

      Volume: (In press)

    • NAID

      10029698098

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in CT Perfusion Maps Generated by Different Commercially Available Software : Analysis Using Identical Source Data of Acute Stroke Patients2010

    • Author(s)
      Kudo K, Sasaki M, Yamada K, Momoshima S, Utsunomiya H, Shirato H, Ogasawara K
    • Journal Title

      Radiology 254

      Pages: 200-209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Change in Venous Oxygenation by Susceptibility-Weighted Imaging in Patients with Spinal Arterio-Venous Malformations after Treatment2010

    • Author(s)
      Fujima N, Kudo K, Terae S, Hida K, Ishizaka K, Zaitsu Y, Asano T, Yoshida D, Tha KK, Sasaki M, Shirato H
    • Journal Title

      Radiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging2010

    • Author(s)
      Sasaki M, Shibata E, Ohtsuka K, Endoh J, Kudo K, Narumi S, Sakai A
    • Journal Title

      Neuroradiology 52

      Pages: 83-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo topographic illustration of microstructural white matter abnorm ahties of multiple system atrophy by diffusion tensor imaging2010

    • Author(s)
      Tha KK, Terae S, Yabe I, Miyamoto T, Soma H, Zaitsu Y, Fujima N, Kudo K, Sasaki H, Shirato H
    • Journal Title

      Radiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in the Tracer Delay-Induced Effect among Deconvolution Algorithms in CT Perfusion Analysis : Quantitative Evaluation by using Digital Phantoms2009

    • Author(s)
      Kudo K, Sasaki M, Ogasawara K, Terae S, Ehara S, Shirato H
    • Journal Title

      Radiology 251

      Pages: 241-249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detectability of Normal Spinal Veins by Using Susceptibility Weighted Imaging2009

    • Author(s)
      Ishizaka K, Kudo K, Fujima N, Zaitsu Y, Yazu R, Tha KK, Terae S, Sasaki M, Shirato H
    • Journal Title

      J Magn Reson Imaging 31

      Pages: 32-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility-weighted magnetic resonance imaging detects impaired cerebral hemodynamics in the superior sagittal sinus thrombosis-case report2009

    • Author(s)
      Kawabori M, Kuroda S, Kudo K, Terae S, Kaneda M, Nakayama N, Iwasaki Y
    • Journal Title

      Neurol Med Chir (Tokyo) 49

      Pages: 248-251

    • NAID

      10025947920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenu ated inversion recovery images of the brain. Part I : pathological conditions.2009

    • Author(s)
      Tha KK, Terae S, Kudo K, Miyasaka K.
    • Journal Title

      Br J Radiol 82

      Pages: 426-434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part II : non-pathological conditions.2009

    • Author(s)
      Tha KK, Terae S, Kudo K, Miyasaka K
    • Journal Title

      Br J Radiol 82

      Pages: 610-614

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry2009

    • Author(s)
      Yamashita F, Sasaki M, Takahashi S, Matsuda H, Kudo K, Narumi S, Terayama Y, Asada T
    • Journal Title

      Neuroradiology 22(Epub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective study on the mismatch concept in acute stroke patients within the first 24h after symptom onset-1000Plus study2009

    • Author(s)
      Hotter B, Pittl S, Ebinger M, Oepen G, Jegzentis K, Kudo K, Rozanski M, Schmidt WU, Brunecker P, Xu C, Martus P, Endres M ; Jungehulsing GJ, Villringer A, Fiebach JB
    • Journal Title

      BMC Neurology 9

      Pages: 60-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ACCURACY AND RELIABILITY OF POST-PROCESSING SOFTWARE FOR CT PERFUSION : QUANTITATIVE ANALYSIS BY DIGITAL PHANTOM2010

    • Author(s)
      Kudo K, Christensen S, Sasaki M, Uwano I, Sasaki T, Ogasawara K, Ostergaard L
    • Organizer
      World Stroke Congress
    • Place of Presentation
      Seoul
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuro Applications of Echelon 1.5T MRI2010

    • Author(s)
      Kudo K
    • Organizer
      MRI Seminar in Singapore
    • Place of Presentation
      Singapore
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢神経:CT/MRIのピットフォール 脳血管障害2010

    • Author(s)
      工藤與亮
    • Organizer
      日本放射線科専門医会・医会ミッドサマーセミナー
    • Place of Presentation
      神戸
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Accuracy and Reliability of Post-Processing Software for DSC MR Perfusion : Quantitative Analysis by Digital Phantom Data2010

    • Author(s)
      Kudo K, Christensen S, Sasaki M, Straka M, Fujiwara S, Ishizaka K, Zaitsu Y, Fujima N, Terae S, Ogasawara K, Ostergaard L
    • Organizer
      ISMRM
    • Place of Presentation
      Stockholm
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Improved Quantification of cerebral blood flow change using phase information of SWI, corrected by arterial oxygen saturation2010

    • Author(s)
      Zaitsu Y, Kudo K, Yazu R, Ishizaka K, Fujima N, Terae S, Sasaki M, Shirato H
    • Organizer
      ISMRM
    • Place of Presentation
      Stockholm
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳卒中の日常臨床における脳循環代謝画像:有用性と限界「CT灌流画像」2010

    • Author(s)
      工藤與亮
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] デジタルファントムを用いたCT灌流画像解析ソフトの精度検証2010

    • Author(s)
      工藤與亮、Soren Christensen、佐々木真理、笹木工、藤原俊朗、小笠原邦昭、Leif Ostergaard
    • Organizer
      日本神経放射線学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] MR灌流画像解析の標準化に向けたデジタルファントムの作成と応用2009

    • Author(s)
      工藤與亮、Soren Christensen、佐々木真理、藤原俊朗、Leif Ostergaard
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] SWI of the Spinal Veins2009

    • Author(s)
      Kudo K
    • Organizer
      ISMRM (International Society for Magnetic Reso nance in Medicine)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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