| Project/Area Number |
21591577
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Keio University (2010-2011)
Dokkyo Medical University (2009) |
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Principal Investigator |
MURAKAMI Koji 慶應義塾大学, 医学部, 教授 (50200267)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Keiichi 獨協医科大学, 医学部, 教授 (70260388)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Positron CT / PET/CT / 11C-メチオニン / 肝機能 / 融合画像 / 造影CT / 呼吸同期 / 核医学 / PET |
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| Research Abstract |
11C-methyonine is one of the amino-acid radiopharmaceuticals using in PET study that shows strong physiological accumulation to the liver. It is said that deposit of 11C-methyonine to liver reflects its function. We examined clinical usefulness of segmental liver function analysis using 11C-methyonine PET/CT before hepatic surgery. Appropriate condition for image acquisition was confirmed at first. We next try to use respiratory gating image acquisition system for improving the precision of image fusion. Development of new software for image analysis was completed by collaboration with a private enterprise. In conclusion, by means of analyzing 11C-methyonine uptake in each liver segment based on anatomical map obtained by CT data, we can validate our new software for evaluating segmental liver function. We have a plan to confirm clinical usefulness of this method to apply various patients who will be performed hepatic surgery.
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