| Project/Area Number |
21591578
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUJI Ichiei 埼玉医科大学, 医学部, 准教授 (90283142)
IMABAYASHI Etsuko 埼玉医科大学, 医学部, 講師 (30406491)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 核磁気共鳴画像 / 核医学 / 放射性医薬品・造影剤 / 医用画像工学 / 神経科学 / 認知症 / 脳神経疾患 / 放射線 / 解剖学 |
|---|
| Research Abstract |
Noninvasive cerebral blood flow measurements using arterial spin labeling(ASL) in MRI and amyloid PET imaging using^<11> C-PiB corrected for partial volume effects were investigated as novel methods for imaging diagnosis of Alzheimer's disease. A software program was developed to statistically analyze an ASL image for a patient as compared with normal database constructed from healthy volunteers. Partial volume correction of amyloid PET image led to accurate quantification of amyloid accumulation in atrophied cerebral cortex in Alzheimer's disease.
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