| Project/Area Number |
21591582
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Katsuyoshi 川崎医科大学, 医学部, 教授 (00274168)
YAMASHITA Takenori 川崎医科大学, 医学部, 講師 (30299200)
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| Co-Investigator(Renkei-kenkyūsha) |
SONE Teruki 川崎医科大学, 医学部, 教授 (90179383)
JO Yoshimasa 川崎医科大学, 医学部, 講師 (40319968)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 前立腺癌 / 核磁気共鳴画像 / MRI |
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| Research Abstract |
In our studies using multiparametric prostate MR imaging, the tumor detectability of prostate cancer before radiotherapy (high-dose-rate brachytherapy (HDR-BT)), the change of MR findings after HDR-BT and the detectability of locally recurrent prostate cancer after HDR-BT were investigated. As the results, multiparametric MRI showed the high detectability for a significant cancer with the treatment intervention. In addition, after radiotherapy, the MR findings in T2-weighted imaging such as zonal indistinctness and diffuse reduction of the signal intensity in the gland interfered with the diagnosis of recurrent tumor. Furthermore, our results indicated that a multiparametric MRI protocol that includes diffusion-weighted imaging provides a sensitive method to detect local recurrence after HDR brachytherapy.
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