| Project/Area Number |
21591583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMADA Tsutomu 川崎医科大学, 医学部, 准教授 (40278932)
YAMASHITA Takenori 川崎医科大学, 医学部, 講師 (30299200)
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| Co-Investigator(Renkei-kenkyūsha) |
UMETANI Keiji 高輝度光科学研究センター, 利用研究促進部門, 主幹研究員 (50344396)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エックス線・CT / 肝血流イメージング / 単色放射光 / 肝血流 / イメージング / 門脈血流 / 門脈血液 |
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| Research Abstract |
3D analysis of regional hepatic blood flow was performed by means of hepatic flow imaging using monochromatic synchrotron radiation. Our results showed that micro-CT enables the evaluation of microanastomosis between small arteries and portal veins as well as the degree of neovascularization. This fact may help elucidate the cause of early enhancing hepatic pseudolesions observed in contrast-enhanced dynamic CT or MRI. Intrahepatic distribution of Gd-EOB-DTPA as a hepatocyte-specific contrast agent was also assessed by using normal and NASH model mouse. In normal mouse, predominant uptake of Gd-EOB-DTPA in the hepatocyte was observed. In NASH model mouse, uptake of Gd-EOB-DTPA gradually decreased, according to the progression of hepatic fibrosis, suggesting the relationship between hepatocyte function and dynamic changes of hepatic blood flow. Regarding the Gd deposition in the liver, Gd deposition in renal dysfunction model rat was minimal. However, Gd deposition was increased in hepatorenal dysfunction model rat, indicating the increased risk of deterioration of liver function.
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