| Project/Area Number |
21591587
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
ITO Hiroshi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (20360357)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Harumasa 放射線医学総合研究所, 分子イメージング研究センター, 室長 (30348792)
TAKAHASHI Hidehiko 放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (60415429)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKAWA Ryosuke 放射線医学総合研究所, 分子イメージング研究センター, 博士研究員 (40350095)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PET / 向精神薬 / 抗精神病薬 / ドーパミン / ドーパミン受容体 |
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| Research Abstract |
Effects of antipsychotic drugs have been considered to be mediated by modulation of postsynaptic dopamine D2 receptors. To investigate the effects of antagonist or partial agonist antipsychotics on presynaptic functions of dopaminergic neurotransmission, changes in dopamine synthesis capacity by antipsychotics, risperidone or aripiprazole, were measured by PET in healthy men. For both antipsychotics, significant negative correlations were observed between the baseline dopamine synthesis capacity and the changes in dopamine synthesis capacity by antipsychotics, indicating that these antipsychotics can be assumed to stabilize the dopamine synthesis capacity.
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