Integrative morphological & functioning imaging analysis in patients with neurodegenerative disease

• Project/Area Number: 21591589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: SATO Noriko 独立行政法人国立精神・神経医療研究センター, 放射線診療部, 部長 (10322017)
• Co-Investigator(Kenkyū-buntansha): ARIMA Kunimasa 独立行政法人 国立精神・神経医療研究センター病院, 第一精神診療部, 部長 (20250227)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 変性疾患 / MRI / 脳血流 / 拡散テンソル / ASL / 拡散テンソ / PSRCT

Research Abstract

Brain imaging examinations were performed in patients with neurodegenerative diseases causing parkinsonism or dementia, and multiple sclerosis. MR DTI showed damaged specific tracts which are supposed to correlated with cognition and a combination of structural brain measure can distinguish parkinsonian syndromes

Research Products

• [Journal Article] Automatic voxel-based morphometry of structural MRI by SPM8 plus DARTEL improves the diagnosis of probable Alzheimer's disease (2012)
  • Author(s): Matsuda H
  • Journal Title: Am J Neuroradiol AJNR Volume: (In press) Issue: 6 Pages: 1109-14
  • DOI: 10.3174/ajnr.a2935
  • Peer Reviewed
• [Journal Article] Postoperative Transient Reduced Diffusion in the Ipsilateral Striatum and Thalamus (2012)
  • Author(s): Kamiya K, Sato N, Nakata Y, Ito K, Kimura Y, Ota M, Takahashi A, Mori H, Kunimatsu A, Ohtomo K
  • Journal Title: AJNR Am J Neuroradiol Volume: 34(3) Issue: 3 Pages: 524-32
  • DOI: 10.3174/ajnr.a3242
• [Journal Article] SISCOM technique with a variable Z score improves detectability of focal cortical dysplasia: a comparative study with MRI (2012)
  • Author(s): Kimura Y, Sato N, Ito K, Kamiya K, Nakata Y, Saito Y, Matsuda H, Sugai K, Sasaki M, Sugimoto H
  • Journal Title: Ann Nucl Med Volume: 26 Issue: 5 Pages: 397-404
  • DOI: 10.1007/s12149-012-0585-4
  • NAID: 10030788534
• [Journal Article] SISCOM technique with a variable Z score improves detectability of focal cortical dysplasia: a comparative study with MRI (2012)
  • Author(s): Kimura Y, Sato N, Ito K, Kamiya K, Nakata Y, Saito Y, Matsuda H, Sugai K, Sasaki M, Sugimoto H.
  • Journal Title: Ann Nucl Med Volume: 2012 Mar 17 Pages: 397-404
  • NAID: 10030788534
  • Peer Reviewed
• [Journal Article] Parasellar T2 dark sign on MR imaging in patients with lymphocytic hypophysitis (2011)
  • Author(s): Nakata Y, Sato N, Masumoto T, Mori H, Akai H, Nobusawa H, Adachi Y, Oba H, Ohtomo K
  • Journal Title: AJNR Am J Neuroradiol Volume: 31 Issue: 10 Pages: 1944
  • DOI: 10.3174/ajnr.a2201
  • URL: https://pure.teikyo.jp/en/publications/e1bfaf03-e10b-42f3-8783-8fed1c85b797
  • Peer Reviewed
• [Journal Article] Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone (2011)
  • Author(s): Hiroshi Matsuda, Etsuko Imabayashi, Ichiei Kuji, Akira Seto, Kimiteru Ito, Daisuke Kikuta, Minoru Yamada, Yasumasa Shimano, Noriko Sato
  • Journal Title: BMC Medical Imaging Volume: Aug 11 Issue: 1 Pages: 10-17
  • DOI: 10.1186/1471-2342-10-17
  • Peer Reviewed
• [Journal Article] Tract-specific analysis for investigation of Alzheimer disease : a brief review. (2010)
  • Author(s): Yasuhiro Nakata, Shigeki Aoki, Noriko Sato, Hasina Yasmin, Yoshitaka Masutani, Kumi Ohtomo.
  • Journal Title: Japan Radiological Society Volume: April 28 Pages: 494-501
  • NAID: 50007671258
  • Peer Reviewed
• [Journal Article] Parasellar T2-dark sign on MRI in patients with lymphocytic hypophysitis. (2010)
  • Author(s): Nakata Y, Sato N, Masumoto T, Mori H, Akai H, Nobusawa H, Adachi Y, Oba H, Ohtomo K.
  • Journal Title: AJNR Am J Neuroradiol Volume: Nov31(10) Pages: 1944-1950
  • Peer Reviewed
• [Journal Article] Evaluation of both perfusion and atrophy in multiple system atropby of the cerebellar type using brain SPECT alone. (2010)
  • Author(s): Hiroshi Matsuda, Etsuko Imabayashi, Ichiei Kuji, Akira Seto, Kimiteru Ito, Daisuke Kikuta, Minoru Yamada, Yasumasa Shimano, Noriko Sato.
  • Journal Title: BMC Medical Imaging Volume: Aug 11 Pages: 10-17
  • Peer Reviewed
• [Presentation] トルコ鞍、傍鞍部領域のMRI (2012)
  • Author(s): 佐藤典子
  • Organizer: 第16回MR実践講座
  • Place of Presentation: ベルサール九段・東京
  • Year and Date: 2012-12-08
• [Presentation] Magnetic resonance imagings of sellar and parasellar regions (2011)
  • Author(s): 佐藤典子
  • Organizer: Neuroimaging 2011
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2011-09-10
• [Presentation] Magnetic resonance imagings of sellar and parasellar regions (2011)
  • Author(s): N.Sato
  • Organizer: Multimodality Seminars Neuroimaging
  • Place of Presentation: Tokyo, Tokyo station conference(招待講演)
  • Year and Date: 2011-09-10
• [Presentation] Alzheimer病および軽度認知機能障害における内側側頭部容積測定 (2011)
  • Author(s): 中田安浩、 松田博史、 山澤眞紀、 小薗実子、 舞草伯秀、 松井博史、 山下典生、 佐藤典子、 岩坪威
  • Organizer: 第70回日本医学放射線学会総会
  • Place of Presentation: Web開催
  • Year and Date: 2011-05-09
• [Presentation] リンパ球性下垂体炎と下垂体腺腫のMRIにおける鑑別診断 (2011)
  • Author(s): 中田安浩、 佐藤典子、 増本智彦、 森墾、 赤井宏行、 信澤宏、 安達木綿子、 大場洋、 大友邦
  • Organizer: 第40回日本神経放射線学会
  • Place of Presentation: 品川
  • Year and Date: 2011-02-27
• [Presentation] 国立精神・神経医療研究センターの既存サイクロトロンの解体作業報告 (2011)
  • Author(s): 伊藤公輝、 中田安浩、 松田博史、 佐藤典子
  • Organizer: 第74回日本核医学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-25
• [Presentation] 限局性皮質形成異常の画像診断におけるSISCOMの有用性 (2011)
  • Author(s): 木村有喜男、 伊藤公輝、 中田安浩、 齊藤祐子、 松田博史、 佐藤典子
  • Organizer: 第74回日本核医学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-22
• [Presentation] 片側扁桃核腫大を伴う側頭葉てんかん-切除2例の病理 (2011)
  • Author(s): 木村有喜男、齊藤祐子、伊藤公輝、中田安浩、鈴木衣子、佐藤典子
  • Organizer: 第52回日本神経病理学会総会
  • Place of Presentation: 京都
• [Presentation] Asymmetric interhemispheric fiber tracts in patients with hemimeg alencephaly on diffusion tensor MRI (2010)
  • Author(s): N.Sato, T.Takahashi, M.Ota, N.Yasuhiro, M.Sasaki.
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Stockholm International Fairs & Congress Center, Stockholm, Sweden
• [Book] 拡散テンソル画像(DTI)見て学ぶ認知症の画像診断 改訂第2版 (2010)
  • Author(s): 石川和宏、中田安浩、佐藤典子、松田博史、 朝田隆編,
  • Publisher: 永井書店
• [Book] 各論15腫瘍および腫瘍様病変 2髄膜の腫瘍. 大場洋編著:小児神経の画像診断 (2010)
  • Author(s): 佐藤典子
  • Publisher: 秀潤社
• [Book] 見て学ぶ認知症の画像診断(改訂第2版) (2010)
  • Author(s): 石川和宏, 中田安浩, 佐藤典子
  • Publisher: 永井書店