Development of new PET probe for tumor imaging using I-124

Research Project

Project/Area Number	21591592
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	FUNAKI Yoshihito 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (50261491)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	ヨウ素124 / 腫瘍 / 小動物PET / ^<124>I / 抗体
Research Abstract	Labeled antibody and labeled modified antibody with I-124 were produced. Those labeled antibodies had specific bindings to cultured tumor cells. Labeled antibodies were not transported to the tumor in case of injection via tail vein but accumulated in urinary bladder. Moreover, it may be suggested that the hydrated electron that was high reductant produced in an aqueous solvent and the oxidized radioiodine was inhibited to generate.