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Development of novel copper-64 labeled antibodies.

Research Project

Project/Area Number 21591593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

TOMINAGA Hideyuki  群馬大学, 大学院・医学系研究科, 寄附講座教員 (00393348)

Co-Investigator(Kenkyū-buntansha) ENDO Keigo  京都医療科学大学, 医療科学部, 学長 (10115800)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords銅-64 / PET / 抗体医薬 / 新規キレート / サイクロトロン / 放射性医薬品 / 診断薬 / 院内製剤 / 新規キレート剤
Research Abstract

In Gunma University, I was enabled in producing copper-64 which was a positron emitter by medical cyclotron. We stably synthesized SarAr cheleter, Sarcophagine, 3, 6, 10, 13, 16, 19-hexaazabicycle[6. 6. 6]-eicosane-1, 8-diamine, as novel chelator for copper-64 labeling. We hope that the application by various labeling antibodies comes to be a new diagnosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (12 results)

  • [Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy2012

    • Author(s)
      Yoshioka H, Tominaga H, Endo K, et al.
    • Journal Title

      Cancer Immunol. Immunother.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography.2012

    • Author(s)
      Achmad A, Tominaga H, Endo K, et al.
    • Journal Title

      Cancer Sci.

      Volume: Vol.103、No.3 Pages: 600-605

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmuno- therapy2012

    • Author(s)
      Yoshioka H
    • Journal Title

      Cancer Immunol Immunother

      Volume: 61(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography2012

    • Author(s)
      Achmad A
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 3 Pages: 600-605

    • DOI

      10.1111/j.1349-7006.2011.02166.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and biological evaluation of 3-[(76)Br]bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors.2011

    • Author(s)
      Ohshima Y, Tominaga H, Endo K, et al.
    • Journal Title

      Nucl. Med. Biol.

      Volume: Vol.38、No.6 Pages: 857-865

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography imaging and biodistribution of vascular endothelial growth factor with 64Cu-labeled bevacizumab in colorectal cancer xenografts.2011

    • Author(s)
      Paudyal B, Tominaga H, Endo K, et al.
    • Journal Title

      Cancer Sci.

      Volume: Vol.102、No.1 Pages: 117-121

    • NAID

      10029288704

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and biological evaluation of 3-[(76)Br]bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors2011

    • Author(s)
      Ohshima Y
    • Journal Title

      Nucl.Med.Biol

      Volume: 38 Pages: 857-865

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography imaging and biodistribution of vascular endothelial growth factor with 64Cu-labeled bevacizumab in colorectal cancer xenografts.2011

    • Author(s)
      Paudyal B
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 117-121

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.2010

    • Author(s)
      Imai H, Tominaga H, et al.
    • Journal Title

      Anticancer Res.

      Volume: Vol.30、No.12 Pages: 4819-4828

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of L-type amino acid transporter 1 expression and L-[3-18F]-α-methyl tyrosine uptake in outcome of non-small cell lung cancer2010

    • Author(s)
      Kaira K, Tominaga H, et al.
    • Journal Title

      Nucl. Med. Biol.

      Volume: Vol.37、No.8 Pages: 911-916

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 18^F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma : comparative study with 18^F-FDG PET and immunohistochemistry.2010

    • Author(s)
      Miyashita G, Tominaga H, Endo K, et al.
    • Journal Title

      Ann. Nucl. Med.

      Volume: Vol.24、No.8 Pages: 579-584

    • NAID

      10027659232

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.2010

    • Author(s)
      Kaira K, Tominaga H, et al.
    • Journal Title

      J. Clin. Oncol.

      Volume: Vol.28、No.23 Pages: 3746-3753

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with Cu-labeled trastuzumab PET.2010

    • Author(s)
      Paudyal P, Tominaga H, Endo K, et al.
    • Journal Title

      Cancer Sci.

      Volume: Vol.101、No.4 Pages: 1045-1050

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual functional molecular imaging probe targeting CD20 with PET and optical imaging.2010

    • Author(s)
      Paudyal B, Paudyal P, Oriuchi N, Hanaoka H, Tominaga H, Endo K, et al.
    • Journal Title

      Oncol. Rep.

      Volume: Vol.22、No.1 Pages: 115-119

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.2010

    • Author(s)
      Imai H
    • Journal Title

      Anticancer Res.

      Volume: 30 Pages: 4819-4828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of L-type amino acid transporter 1 expression and L-[3-18F]-α-methyl tyrosine uptake in outcome of non-small cell lung cancer.2010

    • Author(s)
      Kaira K
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 911-916

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ^<18>F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma : comparative study with ^<18>F-FDG PET and immunohistochemistry.2010

    • Author(s)
      Miyashita G
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 579-584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomoaraohy in thymic epithelial tumors.2010

    • Author(s)
      Kaira K
    • Journal Title

      J Clin Oncol.

      Volume: 28 Pages: 13764-13753

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer.2009

    • Author(s)
      Kaira K, Tominaga H, Endo K
    • Journal Title

      J. Nucl. Med.

      Volume: Vol.50、No.11 Pages: 1770-1776

    • Related Report
      2011 Final Research Report
  • [Journal Article] Evaluation of (64)Cu-labeled DOTA-D-Phe(1)-Tyr (3)-octreotide ((64)Cu-DOTA-TOC) for imaging somatostatin receptor-expressing tumors2009

    • Author(s)
      Hanaoka H, Tominaga H, Endo K, et al.
    • Journal Title

      Ann. Nucl. Med.

      Volume: Vol.23、No.6 Pages: 559-567

    • NAID

      10026390323

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral histamine H1 receptor binding potential measured with PET under a test dose of olopatadine, an antihistamine, is reduced after repeated administration of olopatadine.2009

    • Author(s)
      Senda M, Tominaga H, et al.
    • Journal Title

      J. Nucl. Med

      Volume: Vol.50、No.6 Pages: 887-892

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral histamine H1 receptor binding potential measured with PET under a test dose of olopatadine, an antihistamine, is reduced after repeated administration of olopatadine.2009

    • Author(s)
      Senda M
    • Journal Title

      J.Nucl.Med. 50

      Pages: 887-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of(64)Cu-labeled DOTA-D-Phe(1)-Tyr (3)-octreotide((64)Cu-DOTA-TOC)for imaging somatostatin receptor-expressing tumors.2009

    • Author(s)
      Hanaoka H
    • Journal Title

      Ann.Nucl.Med. 23

      Pages: 559-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual functional molecular imaging probe targeting CD20 with PET and optical imaging.2009

    • Author(s)
      Paudyal P
    • Journal Title

      Oncol.Rep. 22

      Pages: 115-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer.2009

    • Author(s)
      Kaira K
    • Journal Title

      J.Nucl.Med. 50

      Pages: 1770-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射性遷移金属(銅-64)含有製剤の品質管理のための遷移金属分析2011

    • Author(s)
      富永英之
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射性薬剤フルオロメチルチロシンの光学活性分析2011

    • Author(s)
      富永英之
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射性薬剤フルオロメチルチロシンの光学活性分析2011

    • Author(s)
      富永英之
    • Organizer
      日本分析化学会第60年会
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射性遷移金属(銅-64)含有製剤の品質管理のための遷移金属分析2010

    • Author(s)
      富永英之
    • Organizer
      第50回日本分析化学会学術総会
    • Place of Presentation
      埼玉県さいたま市
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射性遷移金属(銅-64)含有製剤に適したバイアルの開発2010

    • Author(s)
      富永英之
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射性遷移金属(銅-64)含有製剤に適したバイアルの開発2010

    • Author(s)
      富永英之
    • Organizer
      日本分析化学会第59年会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射性薬剤に適したバイアルの評価2010

    • Author(s)
      富永英之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター・岡山大学津島キャンパス他(岡山県)
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射性薬剤に適したバイアルの評価2010

    • Author(s)
      富永英之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗体標識を目的としたポリアミンSar誘導体の合成研究2010

    • Author(s)
      小井沼怜, 富永英之
    • Organizer
      第24回日本高分子学会
    • Place of Presentation
      群馬県
    • Year and Date
      2010-03-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗体標識を目的としたポリアミンSar誘導体の合成研究2010

    • Author(s)
      小井沼怜
    • Organizer
      第24回 日本高分子学会 群馬・栃木地区講演会
    • Place of Presentation
      群馬県桐生市
    • Year and Date
      2010-03-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] (64)Cu-DOTA-octreotideの有用性2009

    • Author(s)
      花岡宏史, 富永英之
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川市民文化会館・旭川グランドホテル(北海道)
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] (64)Cu-DOTA-octreotideの有用性2009

    • Author(s)
      花岡宏史
    • Organizer
      第49回 日本核医学会学術総会
    • Place of Presentation
      北海道旭川市
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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