Radifrequency ablation for resectable colorectal lung metastasis: A prospective clinical trial

• Project/Area Number: 21591595
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: YAMAKADO Koichiro 三重大学, 医学部附属病院, 准教授 (20263022)
• Co-Investigator(Kenkyū-buntansha): YASUHIRO Inoue 三重大学, 医学部附属病院, 講師 (20324535) ; MOTOSHI Takao 三重大学, 医学部附属病院, 准教授 (30263007) ; HARUYUKI Takaki 三重大学, 医学部, 医員 (30378377)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大腸癌 / 転移性肺がん / ラジオ波焼灼術 / 転移性肺癌 / ラジオ波凝固療法 / 肺転移

Research Abstract

This prospective clinical trial was undertaken to evaluate the clinical utility of lung radiofrequency ablation (RFA) used for the treatment of resectable colorectal ling metastases. The primary endpoint of this study was the 3-year overall survival. Seventy patients were enrolled in April 2014. The results will be opened in 2019.

Research Products

• [Journal Article] Radiofrequency ablation versus radical nephrectomy:clinical outcomes for stage T1b renal cell carcinoma (2014)
  • Author(s): Takaki H, Soga N, Kanda H, Nakatsuka A, Uraki J, Fujimori M, Yamanaka T, Hasegawa T, Arima K, Sugimura Y, Sakuma H, Yamakado K
  • Journal Title: Radiology Volume: 270(1)(Epub 2013 Oct 28. PMID:23925272, PubMed - indexed for MEDLINE) Issue: 1 Pages: 292-9
  • DOI: 10.1148/radiol.13130221
• [Journal Article] Limited expression of cancer-testis antigens in renal cell carcinoma patients (2013)
  • Author(s): Soga N, Hori Y, Yamakado K, Ikeda H, Imai N, Kageyama S, Nakase K, Yuta A, Hayashi N, Shiku H, Sugimura Y
  • Journal Title: Mol Clin Oncol Volume: 1(2), (Epub, PMID:24649170) Pages: 326-330
• [Journal Article] Radiofrequency ablation for the treatment of recurrent bone and soft-tissue sarcomas in non-surgical candidates (2013)
  • Author(s): Yamakado K, Matsumine A, Nakamura T, Nakatsuka A, Takaki H, Matsubara T, Asanuma K, Sudo A, Sugimura Y, Sakuma H
  • Journal Title: Int J Clin Oncol Volume: (Epub ahead of print, PMID:24287606, PubMed - as supplied by publisher)
• [Journal Article] Rib fractures after radiofrequency and microwave ablation of lung tumors (2013)
  • Author(s): Yamakado K, Takaki H, Nakatsuka A
  • Journal Title: Radiology Volume: 269(3) Issue: 3 Pages: 946-946
  • DOI: 10.1148/radiol.13131612
• [Journal Article] Radiofrequency Ablation After Arterial Injection of Miriplatin-Iodized Oil Suspension Into Swine Liver:Ablative Zone Size and Tissue Platinum Concentration (2013)
  • Author(s): Yamanaka T, Takaki H, Nakatsuka A, Uchida K, Junji U, Fujimori M, Hasegawa T, Yoneda M, Shiraishi T, Sakuma H, Yamakado K
  • Journal Title: Cardiovasc Intervent Radiol Volume: (Epub ahead of print, PMID:24232037, PubMed - as supplied by publisher)
• [Journal Article] Clinical significance of radiofrequency ablation and metastasectomy in elderly patients with lung metastases from musculoskeletal sarcomas (2013)
  • Author(s): Nakamura T, Matsumine A, Yamakado K, Takao M, Uchida A, Sudo A
  • Journal Title: J Cancer Res Ther Volume: 9(2)(PMID:23771362, PubMed - indexed for MEDLINE) Issue: 2 Pages: 219-23
  • DOI: 10.4103/0973-1482.113358
  • Peer Reviewed
• [Journal Article] Impact of 18F-FDG-PET/CT on treatment strategy in colorectal cancer lung metastasis before lung radiofrequency ablation (2013)
  • Author(s): Kodama H, Yamakado K, Takaki H, Suzawa N, Yamada T, Takeda K
  • Journal Title: Nucl Med Commun Volume: 34(7)(PMID:23636294, PubMed - indexed for MEDLINE) Issue: 7 Pages: 689-93
  • DOI: 10.1097/mnm.0b013e328361cd28
  • Peer Reviewed
• [Journal Article] Response to "the use of radiofrequency ablation in gastrointestinal stromal tumor" (2013)
  • Author(s): Yamanaka T, Takaki H, Nakatsuka A, Uraki J, Fujimori M, Hasegawa T, Sakuma H, Yamakado K
  • Journal Title: J Vasc Interv Radiol Volume: 24(5), (PMID:23622045) Issue: 5 Pages: 751-751
  • DOI: 10.1016/j.jvir.2013.02.025
• [Journal Article] Outcome for pulmonary metastases from malignant osteogenic and soft tissue sarcomas (2013)
  • Author(s): Tempaku H, Takao M, Shimamoto A, Murashima S, Yamakado K, Nakamura T, Matsumine A, Shimpo H
  • Journal Title: Kyobu Geka Volume: 66(4), (PMID:23575184, PubMed - indexed for MEDLINE) Pages: 311-4
  • NAID: 40019637420
• [Journal Article] Frequency of and risk factors for complications after liver radiofrequency ablation under CT fluoroscopic guidance in 1500 sessions:single-center experience (2013)
  • Author(s): Takaki H, Yamakado K, Nakatsuka A, Yamada T, Shiraki K, Takei Y, Takeda K
  • Journal Title: AJR Am J Roentgenol Volume: 200(3), (PMID:23436859, PubMed - indexed for MEDLINE) Issue: 3 Pages: 658-64
  • DOI: 10.2214/ajr.12.8691
• [Journal Article] Detection of local tumor progression by (18)F-FDG PET/CT following lung radiofrequency ablation:PET versus CT (2013)
  • Author(s): Suzawa N, Yamakado K, Takao M, Taguchi O, Yamada T, Takeda K
  • Journal Title: Clin Nucl Med Volume: 38(4), (PMID:23429399, PubMed - indexed for MEDLINE) Issue: 4 Pages: 166-170
  • DOI: 10.1097/rlu.0b013e31828166f6
  • Peer Reviewed
• [Journal Article] Survival with up to 10-year follow-up after combination therapy of chemoembolization and radiofrequency ablation for the treatment of hepatocellular carcinoma:single-center experience (2013)
  • Author(s): Fujimori M, Takaki H, Nakatsuka A, Uraki J, Yamanaka T, Hasegawa T, Shiraki K, Takei Y, Sakuma H, Yamakado K
  • Journal Title: J Vasc Interv Radiol Volume: 24(5), (Epub 2013 Feb 18. PMID:23428356) Issue: 5 Pages: 655-66
  • DOI: 10.1016/j.jvir.2012.12.009
• [Journal Article] Hyaluronic acid gel injection to prevent thermal injury of adjacent gastrointestinal tract during percutaneous liver radiofrequency ablation (2013)
  • Author(s): Hasegawa T, Takaki H, Miyagi H, Nakatsuka A, Uraki J, Yamanaka T, Fujimori M, Sakuma H, Yamakado K
  • Journal Title: Cardiovasc Intervent Radiol Volume: 36(4), (Epub 2013 Jan 25. PMID:23354960, PubMed - indexed for MEDLINE) Issue: 4 Pages: 1144-6
  • DOI: 10.1007/s00270-013-0546-x
• [Journal Article] Radiofrequency ablation for liver metastasis from gastrointestinal stromal tumor (2013)
  • Author(s): Yamanaka T, Takaki H, Nakatsuka A, Uraki J, Fujimori M, Hasegawa T, Sakuma H, Yamakado K
  • Journal Title: J Vasc Interv Radiol Volume: 24(3), (PMID:23352855, PubMed - indexed for MEDLINE) Issue: 3 Pages: 341-6
  • DOI: 10.1016/j.jvir.2012.11.021
• [Journal Article] Renal cell carcinoma:radiofrequency ablation with a multiple-electrode switching system--a phase II clinical study (2013)
  • Author(s): Takaki H, Nakatsuka A, Uraki J, Yamanaka T, Fujimori M, Hasegawa T, Arima K, Sugimura Y, Yamakado K
  • Journal Title: Radiology Volume: 267(1), (PMID:23315660) Issue: 1 Pages: 285-92
  • DOI: 10.1148/radiol.12121070
• [Journal Article] CT-fluoroscopy in chest interventional radiology: sliding scale of imaging parameters based on radiation exposure dose and factors increasing radiation exposure dose. (2013)
  • Author(s): Yamao Y, Yamakado K, Takaki H, Yamada T, Kodama H, Nagasawa N, Nakatsuka A, Uraki J, Takeda K.
  • Journal Title: Clin Radiol Volume: ６８ Issue: 2 Pages: 162-166
  • DOI: 10.1016/j.crad.2012.05.020
  • Peer Reviewed
• [Journal Article] Outcome for pulmonary metastases from malignant osteogenic and soft tissue sarcomas]. (2013)
  • Author(s): Tempaku H, Takao M, Shimamoto A, Murashima S, Yamakado K, Nakamura T, Matsumine A, Shimpo H.
  • Journal Title: Kyobu Geka Volume: 66 Pages: 311-314
  • NAID: 40019637420
  • Peer Reviewed
• [Journal Article] Combination therapy of chemoembolization and radiofrequency ablation for the treatment of hepatocellular carcinoma in the caudate lobe (2012)
  • Author(s): Fujimori M, Takaki H, Nakatsuka A, Uraki J, Yamanaka T, Hasegawa T, Shiraki K, Takei Y, Yamakado K
  • Journal Title: J Vasc Interv Radiol Volume: 23(12), (PMID:23177108) Issue: 12 Pages: 1622-8
  • DOI: 10.1016/j.jvir.2012.09.005
• [Journal Article] Ablative zone size created by radiofrequency ablation with and without chemoembolization in small hepatocellular carcinomas. (2012)
  • Author(s): Takashi Yamanaka
  • Journal Title: Japanese journal of RAdiology Volume: 30 Issue: 7 Pages: 553-559
  • DOI: 10.1007/s11604-012-0087-2
  • Peer Reviewed
• [Journal Article] Incidence and cause of hypertension during adrenal radiofrequency ablation. (2012)
  • Author(s): Koichiro Yamakado
  • Journal Title: Cardiovascular and interventional radiology Volume: 35 Issue: 6 Pages: 1422-1427
  • DOI: 10.1007/s00270-012-0348-6
• [Journal Article] Adrenal radiofrequency ablation in swine : change in blood pressure and histopathologic analysis (2011)
  • Author(s): Yamakado K, 他
  • Journal Title: Cardiovasc Intervent Radiol Volume: 34 Pages: 839-844
  • Peer Reviewed
• [Journal Article] Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic guided radiofrequency ablation : preliminary results (2011)
  • Author(s): Iwamoto Y, Kanda H, Yamakado K, 他
  • Journal Title: Fam Cancer Volume: 10 Pages: 529-534
  • Peer Reviewed
• [Journal Article] Percutaneous radiofrequency ablation for pulmonary metastases from hepatocellular carcinoma : results of a multicenter study in Japan (2011)
  • Author(s): Hiraki T, Yamakado K, 他
  • Journal Title: J Vase Interv Radiol Volume: 22 Pages: 741-748
  • Peer Reviewed
• [Journal Article] Optimal scan parameters for CT fluoroscopy in lung interventional radiologic procedures : relationship between radiation dose and image quality. (2010)
  • Author(s): Yamao Y, Yamakado K, 他
  • Journal Title: Radiology Volume: 255(1): Pages: 233-241
  • Peer Reviewed
• [Journal Article] Midterm results of radiofrequency ablation versus nephrectomy for T1a renal cell carcinoma. (2010)
  • Author(s): Takaki H, Yamakado K, 他
  • Journal Title: Jpn J Radiol Volume: 28 Pages: 460-468
  • NAID: 50007723506
  • Peer Reviewed
• [Journal Article] Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation. (2010)
  • Author(s): Beppu T, Yamakado K, 他
  • Journal Title: Int J Mol Med. Volume: 26 Pages: 425-433
  • Peer Reviewed
• [Journal Article] Adrenal metastasis from hepatocellular carcinoma: radiofrequency ablation combined with adrenal arterial chemoembolization in six patients (2009)
  • Author(s): Yamakado K, Takaki H, 他5名
  • Journal Title: Am J Roentgenol. 192 Pages: 300-305
  • Peer Reviewed
• [Journal Article] Long-term results of radiofrequency ablation in colorectal lung metastases : single center experience (2009)
  • Author(s): Yamakado K, Inoue Y, Takao M, Takaki H, 他6名
  • Journal Title: Oncol Rep. 22 Pages: 885-891
  • Peer Reviewed
• [Journal Article] Subphrenic versus nonsubphrenic hepatocellular carcinoma : combined therapy with chemoembolization and radiofrequency ablation (2009)
  • Author(s): Yamakado K, Takaki H, 他6名
  • Journal Title: Am J Roentgenol. 194 Pages: 530-535
  • Peer Reviewed
• [Presentation] 肺腫瘍に対するRFA (2013)
  • Author(s): 山門亨一郎
  • Organizer: 2013ミッドウインターセミナー
  • Place of Presentation: 福岡
• [Presentation] クッシング症候群に対するIVR:RFA (2013)
  • Author(s): 山門亨一郎
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 仙台
• [Presentation] 肺RFA (2013)
  • Author(s): 山門亨一郎
  • Organizer: ミッドウィンターセミナー
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Combination of TACE and RFA (2012)
  • Author(s): Yamakado K
  • Organizer: APCCVIR
  • Place of Presentation: Kobe
• [Presentation] この症例をどう治療するか?消化管に近接した肝被膜下HCC症例 (2012)
  • Author(s): 山門亨一郎
  • Organizer: 第7回肝癌治療シミュレーション研究会
  • Place of Presentation: 熊本
• [Presentation] 肝RFA-最近の進歩 (2011)
  • Author(s): 山門亨一郎
  • Organizer: 日本医学放射線学会秋季大会
  • Place of Presentation: 山口県下関市(招待講演)
  • Year and Date: 2011-10-22
• [Presentation] Radiofrequency ablation for lung tumors (2010)
  • Author(s): Yamakado K
  • Organizer: Radiology Society Republic of China
  • Place of Presentation: 台湾、台北(招待講演)
  • Year and Date: 2010-12-17
• [Presentation] Radiofrequency ablation for lung metastasis (2010)
  • Author(s): Yamakado K
  • Organizer: 第96回北米放射線学会(シカゴ)
  • Place of Presentation: 米国、シカゴ(招待講演)
• [Presentation] Presentation of a scientific paper in English : A nonnative English speaker's experience (2010)
  • Author(s): Yamakado K
  • Organizer: 第4回Society of gastrointestinal intervention
  • Place of Presentation: 韓国、ソウル(招待講演)
• [Presentation] RFA装置 (2010)
  • Author(s): 山門亨一郎
  • Organizer: 第39回日本IVR学会総会
  • Place of Presentation: 東京(招待講演)
• [Presentation] シンポするアブレーション:その他のRFA (2010)
  • Author(s): 山門亨一郎
  • Organizer: 第39回日本IVR学会総会
  • Place of Presentation: 東京(招待講演)
• [Presentation] Therapeutic strategy for stage IA non-small cell lung cancer : Radiofrequency ablation (2009)
  • Author(s): 山門亨一郎
  • Organizer: 50th JSLC/IASLC joint workshop on Advances in Lung Cancer
  • Place of Presentation: 東京
  • Year and Date: 2009-11-14
• [Book] IVRマニュアル第2版:ラジオ波凝固療法(腎) (2011)
  • Author(s): 栗林幸夫、増田裕、似鳥俊明、中村健治、吉岡哲也、廣田省三、早川克己、橋本統、福田哲也、東浦渉、田中良一、高山勝年、吉川公彦、石口恒男、杉本幸司、南口博紀、佐藤守男、田島康之、加地辰美、三村秀文、金澤右、古井滋、神武裕、岩田美郎、齋藤拓郎、成松芳明、古川顕、井隼孝司、西田典史、勝盛哲也、大須賀慶悟、坂口浩、羽室雅夫、宮山士朗、山上卓士、佐藤修、藤田正人、井上祐喜、今井茂樹、阿部等思、山本聡、山下寛高、西巻博、磯部義憲、橋本一樹、淀野啓、松岡利幸、堺幸正。前田弘彰、荒井保明、松尾国弘、松本真一、興梠征典、掛田伸吾、井上正義、森田壮二郎、齋藤博哉、山本孝信、小川晋久、滝澤謙治、田頭周一、神納敏夫、穴井洋、山門亨一郎、谷川昇、最上拓児、原田潤太、中塚誠之、蘆田浩、古市欣也、新槙剛、熊野玲子、山内栄五郎、高菜健寛、稲葉吉隆、前田宗宏、下山恵司、丹呉惠理、野宮香織、松田麻衣子、米山美和子、も井山萬秀、市田隆雄、鈴木滋、米虫敦、水沼仁孝.
  • Publisher: 医学書院
• [Book] ガイドラインサポートハンドブック 大腸癌 大腸癌治療ガイドライン2009年版 (2009)
  • Author(s): 山門亨一郎
  • Total Pages: 239
  • Publisher: 医薬ジャーナル