Application of HIFU(High intensity focused ultrasound) to the treatment of liver cancer and evaluation of combined treatment of HIFU and RFA.

• Project/Area Number: 21591596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: SHIBATA Toshiya 京都大学, 医学研究科, 准教授 (60162632)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: HIFU / RFA / 肝癌

Research Abstract

The coagulation area obtained by HIFU and RFA was compared in ex vivo and in vivo animal livers. In both ex vivo and in vivo studies, RFA has gained larger, homogeneous coagulation area with shorter treatment time than HIFU. A shortcoming of HIFU has been demonstrated to be longer treatment time and insufficient penetration. There might be some problems for the clinical application of HIFU to human liver cancer.

Research Products

• [Journal Article] Standard of hepatic vein reconstruction with patch plasty using native portal vein in adult living donor liver transplantation (2012)
  • Author(s): Mori A, Kaido T, Ogura Y, Ogawa K, Hata K, Yagi S, Yoshizawa A, Isoda H, Shibata T, Uemoto S.
  • Journal Title: Liver Transpl Volume: 17巻(In press) Issue: 5 Pages: 602-607
  • DOI: 10.1002/lt.23387
  • Peer Reviewed
• [Journal Article] Stent angioplasty for a kink in the pulmonary artery anastomosis soon after living-donor lobar lung transplantation (2012)
  • Author(s): Chen F,---, Shibata T,--, et al
  • Journal Title: Ann Thorac Surg Volume: 92(5) Issue: 5 Pages: 105-106
  • DOI: 10.1016/j.athoracsur.2011.05.049
  • Peer Reviewed
• [Journal Article] Contrast behavior of high-spatial-resolution T1-weighted MR imaging at 3.0 T vs.1.5 T (2012)
  • Author(s): Isoda H,---, Shibata T,--, et al
  • Journal Title: Clin Imaging Volume: 35(2) Pages: 133-138
  • Peer Reviewed
• [Journal Article] Early evaluation of Tran catheter arterial chemoembolization-refractory hepatocellular carcinoma (2011)
  • Author(s): Yamanaka K, Hatano E, Kitamura K, Iida T, Ishii T, Machimito T, Taura K, Yasuchika K, Isoda H, Shibata T, Uemoto S.
  • Journal Title: J Gastroenterol Volume: (Epub ahead of print) Issue: 3 Pages: 343-346
  • DOI: 10.1007/s00535-011-0511-x
  • Peer Reviewed
• [Journal Article] Stent angioplasty for a kink in the pulmonary artery anastomosis soon after living-donor lobar lung transplantation. (2011)
  • Author(s): Chen F, Tazaki J, Shibata T, Miwa S, Yamazaki K, Ishii H, Shoji T, Fujinaga T, Bando T, Date H.
  • Journal Title: Ann Thorac Surg Volume: 92(5) Pages: 105-106
  • URL: http://dx.doi.org/10.1016/j.athoracsur.2011.05.049
  • Peer Reviewed
• [Journal Article] Contrast behavior of high-spatial-resolution T1-weighted MR imaging at 3. 0T vs. 1. 5T (2011)
  • Author(s): Isoda H, Arizono S, Shimada K, Hirokawa Y, Maetani YS, Kataoka M, Nakamoto Y, Shibata T, Togashi K.
  • Journal Title: Clin Imaging Volume: 35(2) Pages: 133-138
  • URL: http://dx.doi.org/10.1016/j.clinimag.2010.04.004
  • Peer Reviewed
• [Journal Article] Comparative study of cisplatin and epirubicin in Tran catheter arterial chemoembolization for hepatocellular carcinoma (2011)
  • Author(s): Yamanaka K, Hatano E, Narita M, Taura K, Yasuchika K, Nitta T, Arizono S, Isoda H, Shibata T, Ikai I, Sato T, Uemoto S.
  • Journal Title: Hepatol Res Volume: 41(4) Issue: 4 Pages: 303-309
  • DOI: 10.1111/j.1872-034x.2010.00770.x
  • Peer Reviewed
• [Journal Article] Non-contrast-enhanced hepatic MR angiography : do two-dimensional parallel imaging and short tau inversion recovery methods shorten acquisition time without image quality deterioration (2011)
  • Author(s): Shimada K, Isoda H, Okada T, Kamae T, Arizono S, Hirokawa Y, Shibata T, and Togashi K.
  • Journal Title: European Journal of Radiology Volume: 77(1) Pages: 137-142
  • Peer Reviewed
• [Journal Article] FDG PET for giant cavernous hemangioma : important clue to differentiate from a malignant vascular tumor in the liver (2010)
  • Author(s): Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K.
  • Journal Title: Clin Nucl Med Volume: 35(12) Pages: 924-926
  • Peer Reviewed
• [Journal Article] Hepatic venous outflow obstruction in pediatric living donor liver transplantation using left-sided lobe grafts : Kyo University experience (2010)
  • Author(s): Sakamoto S, Egawa H, Kanazawa H, Shibata T, Miyagawa-Hayashino A, Haga H, Ogura Y, Kasahara M, Tanaka K, Uemoto S.
  • Journal Title: Liver Transpl Volume: 16(10) Pages: 1207-1214
  • Peer Reviewed
• [Journal Article] Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases (2010)
  • Author(s): Shimada K, Isoda H, Hirokawa Y, Arizono S, Shibata T, Togashi K.
  • Journal Title: Eur Radiol Volume: 20(11) Pages: 2690-2698
  • Peer Reviewed
• [Journal Article] Improved Detection of Hepatic Metastases From Pancreatic Cancer Using Periodically Rotated Overlapping Parallel Lines With Enhanced Reconstruction(PROPELLER) Technique After SPIO Administration (2010)
  • Author(s): Hirokawa Y, Isoda H, Okada T, Arizono S, Shimada K, Yamamoto A, Shibata T, Togashi K.
  • Journal Title: Invest Radiol Volume: 45(3) Pages: 158-164
  • Peer Reviewed
• [Journal Article] Balloon-occluded retrograde Tran venous obliteration for duodenal varices complicated by intraprocedural rupture followed by sepsis (2010)
  • Author(s): Akasaka T, Shibata T, Isoda H, Arizono S, Shimada K, Taura K, Togashi K.
  • Journal Title: Cardiovasc Intervent Radiol Volume: 33(6) Pages: 1257-1261
  • Peer Reviewed
• [Journal Article] High spatial resolution 3D MR cholangiography with high sampling efficiency technique(SPACE): Comparison of 3. 0Tvs1. 5T (2010)
  • Author(s): Nakamoto Y, Shibata T, Togashi K.
  • Journal Title: Eur J Radiol Volume: 73(1) Pages: 114-118
  • Peer Reviewed
• [Journal Article] Septic complication after balloon-occluded retrograde transvenous obliteration of duodenal variceal bleeding. (2010)
  • Author(s): Akasaka T, Shibata T, (2番目, 他5名)
  • Journal Title: Cardiovasc Intervent Radiol. Volume: 33(6) Pages: 1257-1261
  • Peer Reviewed
• [Journal Article] Improved detection of hepatic metastases from pancreatic cancer using periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique after SPIO administration. (2010)
  • Author(s): Hirokawa Y, …, Shibata T, (7番目, 他6名)
  • Journal Title: Invest Radiol. Volume: 45(3) Pages: 158-169
  • Peer Reviewed
• [Journal Article] Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases. (2010)
  • Author(s): Shimada K, …, Shibata T, (5番目, 他4名)
  • Journal Title: Eur Radiol. Volume: 20(11) Pages: 2690-2698
  • Peer Reviewed
• [Journal Article] Hepatic venous outflow obstruction in pediatric living donor liver transplantation using left-sided lobe grafts : Kyoto University experience (2010)
  • Author(s): Sakamoto S, …, Shibata T, (4番目, 他8名)
  • Journal Title: Liver Transpl. Volume: 16(10) Pages: 1207-1214
  • Peer Reviewed
• [Journal Article] FDG PET for giant cavernous hemangioma : important clue to differentiate from a malignant vascular tumor in the liver (2010)
  • Author(s): Shimada K, …, Shibata T, (6番目, 他5名)
  • Journal Title: Clin Nucl Med. Volume: 35(12) Pages: 924-926
  • Peer Reviewed
• [Journal Article] Comparative study of cisplatin and epirubicin in transcatheter arterial chemoembolization for hepatocellular carcinoma. (2010)
  • Author(s): Yamanaka K, …, Shibata T, (9番目, 他10名)
  • Journal Title: Hepatol Res. Volume: 41(4) Pages: 303-309
  • NAID: 10031144094
  • Peer Reviewed
• [Journal Article] Contrast behavior of high-spatial-resolution Tl-weighted MR imaging at 3.0T vs.1.5T. (2010)
  • Author(s): Isoda H, …, Shibata T, (8番目, 他7名)
  • Journal Title: Clin Imaging. Volume: 35(2) Pages: 133-138
  • Peer Reviewed
• [Journal Article] Improved Detection of Hepatic Metastases From Pancreatic Cancer Using Periodically Rotated Overlapping Parallel Lines With Enhanced Recon struction (PROPELLER) Technique After SPIO Administration. (2010)
  • Author(s): Hirokawa Y, Shibata T, (7番目、他6名)
  • Journal Title: Invest Radiol. Epub ahead of print
  • Peer Reviewed
• [Journal Article] Balloon-occluded retrograde transvenous obliteration for duodenal varices complicated by intraprocedural rupture followed by sepsis. (2009)
  • Author(s): Akasaka T, Shibata T, (2番目、他5名)
  • Journal Title: Cardiovasc Intervent Radiol Epub ahead of print
  • Peer Reviewed
• [Journal Article] Non-contrast-enhanced hepatic MR angiography : do two-dimensional parallel imaging' and short tau inversion recovery methods shorten acquisition time without image quality deterioration? (2009)
  • Author(s): Shimada K, Shibata T, (7番目、他6名)
  • Journal Title: European Journal of Radiology Epub ahead of print
  • Peer Reviewed
• [Journal Article] Small hepatocellular carcinoma : Is radiofrequency ablation combined with transcatheter arterial chemoembolization more effective than radiofreq uency ablation alone for treatment? (2009)
  • Author(s): Shibata T, (1番目、他5名)
  • Journal Title: Radiology 252(3) Pages: 905-913
  • Peer Reviewed
• [Journal Article] Improved MR Image quality and detection of hepatic lesions with periodically rotated overlapping parallel lines with enhanced reconstruction technique : evaluation of SPIO contrast enhanced T2-weighted images. (2009)
  • Author(s): Hirokawa Y, Shibata T, (5番目、他4名)
  • Journal Title: Radiology 251(2) Pages: 388-397
  • Peer Reviewed
• [Journal Article] Non-contrast-enhanced MR portography with time-spatial labeling inversion pulses : comparison of imaging with three-dimensional half-fourier fast spin-echo and true steady-state free-precession sequences. (2009)
  • Author(s): Shimada K, Shibata T, (7番目、他6名)
  • Journal Title: J Magn Reson Imaging 29(5) Pages: 1140-1146
  • Peer Reviewed
• [Journal Article] Non-contrast-enhanced MR angiography for selective visualization of the hepatic vein and inferior vena cava with true steady-state free-precessi on sequence and time-spatial labeling inversion pulse : preliminary results. (2009)
  • Author(s): Shimada K, Shibata T, (8番目、他7名)
  • Journal Title: J Magn Reson Imaging 29(2) Pages: 474-479
  • Peer Reviewed
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles(Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T, Yabuta M, Shibata T, Isoda H, Togashi K.
  • Organizer: the 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-27
• [Presentation] Multichannel radiofrequency excitation upper abdominal MR imaging at 3T : challenges and their solutions (2011)
  • Author(s): Shimizu H, Isoda H, Kawahara S, Shimada T, Shibata T, Togashi K.
  • Organizer: the 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-27
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles(Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T, Shibata T, Yabuta M, Isoda H, Togashi K.
  • Organizer: Electronic Posters
  • Place of Presentation: Munich
  • Year and Date: 2011-09-10
• [Presentation] IVR達人への道(1) S-12小肝細胞癌に対するソナゾイド造影USガイドRFAの有用性 (2011)
  • Author(s): 柴田登志也、芝田豊通、薮田実、磯田裕義、富樫かおり
  • Organizer: 第40回日本IVR学会総会
  • Place of Presentation: 於青森市文化会館
  • Year and Date: 2011-05-19
• [Presentation] 小肝細胞癌に対するソナゾイド造影USガイドRFAの有用性 (2011)
  • Author(s): 柴田登志也、---
  • Organizer: 第40回日本IVR学会総会
  • Place of Presentation: 青森市文化会館
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles (Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T,---
  • Organizer: the 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles (Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T,---
  • Organizer: CIRSE 2011
  • Place of Presentation: Munich
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2011)
  • Author(s): Yabuta M, Shibata T,---
  • Organizer: CIRSE 2011
  • Place of Presentation: Munich
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2010)
  • Author(s): Shibata T, Isoda H, Shimada K, Togashi K.
  • Organizer: the 96th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2010-12-01
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2010)
  • Author(s): Shibata T, …, (1番目, 他3名)
  • Organizer: RSNA2010
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-12-01
• [Presentation] Percutaneous transhepatic angioplasty for anastomotic stenosis of portal vein in patients with living donor liver transplantation : long-term results (2010)
  • Author(s): Shibata T, Isoda H, Togashi K.
  • Organizer: FP1204-TIPS and portal vein intervention
  • Place of Presentation: Valencia
  • Year and Date: 2010-10-03
• [Presentation] Percutaneous transhepatic angioplasty for anastomotic stenosis of portal vein in pattients with lwing donor Ifiver transplantation : long-term results (2010)
  • Author(s): Shibata T, …, (1番目, 他2名)
  • Organizer: CIRSEZOIO
  • Place of Presentation: Valencia, Spain
  • Year and Date: 2010-10-03
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2010)
  • Author(s): Yabuta M, Shibata T, Shibata T, Isoda H, Togashi K.
  • Organizer: Electronic Posters
  • Place of Presentation: Munich
  • Year and Date: 2010-09-10
• [Presentation] 肝移植後合併症に対するIVRS-29生体肝移植後肝静脈狭窄に対するIVR (2010)
  • Author(s): 柴田登志也、磯田裕義、富樫かおり
  • Organizer: 第39回日本IVR学会総会
  • Place of Presentation: 於浅草ビューホテル
  • Year and Date: 2010-05-21
• [Presentation] シンポジウム6肝移植後合併症に対するIVR;生体肝移植後肝静脈狭窄に対するIVR (2010)
  • Author(s): 柴田登志也, …, (1番目, 他2名)
  • Organizer: 第39回日本IVR学会総会
  • Place of Presentation: 浅草ビューホテル
  • Year and Date: 2010-05-21
• [Presentation] Current development of liver RFA procedure : Combination of TAE with RFA. (2009)
  • Author(s): Shibata T
  • Organizer: 1st Japan Korea Image Guided Tumor Ablation Meeting
  • Place of Presentation: Villa Shiodome Conference Center, Tokyo
  • Year and Date: 2009-09-12
• [Presentation] パネルディスカッション1.「凝固療法の適応と限界及び合併症」-対策と工夫- PD1-07小肝細胞癌に対するREAとTACE併用療法の有用性・限界 (2009)
  • Author(s): 柴田登志也, (1番目、他4名)
  • Organizer: 第45回日本肝癌研究会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-07-03