| Project/Area Number |
21591602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Niigata University (2010-2013)
Hokkaido University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERAE Satoshi 北海道大学, 大学病院, 准教授 (40240634)
SHIGA Toru 北海道大学, 医学(系)研究科, 准教授 (80374495)
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| Co-Investigator(Renkei-kenkyūsha) |
ONODERA Shunsuke 北海道大学, 医学(系)研究科, 特任助教 (30374458)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 放射線治療 / 認知機能 / 脳腫瘍 / 拡散テンソル画像 / 神経イメージング / 転移性脳腫瘍 / 全脳照射 / 定位放射線照射 |
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| Research Abstract |
Adverse radiation effect after brain radiation may cause severe deterioration of neurocognitive function (NCF). The lack of standardized objective scale to determine the severity of the decline of NCF has been an obstacle to investigate the way to prevent and/or treat this condition. We assorted Japanese version of neurocognitive battery which is compatible to those used in Western countries. In a prospective study, this NCB demonstrated deterioration of NCF 4 months after whole-brain radiation therapy (WBRT), recovery at 8 months, and decline at 12 months. In the examination of diffusion tensor imaging, mean diffusivity (MD), which could be a potential index to determine the damage to white matter, continued to increase overtime. At 8 months after radiation, the magnitude of %difference of MD compared with baseline was greatest at corpus callosum followed by cingulate. The correlation of findings in DTI and NCB is a matter of further investigation.
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