Investigation of decline of neurocognitive function after cranial radiation therapy for brain tumors and exploring early diagnostic method
Project/Area Number |
21591602
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Niigata University (2010-2013) Hokkaido University (2009) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TERAE Satoshi 北海道大学, 大学病院, 准教授 (40240634)
SHIGA Toru 北海道大学, 医学(系)研究科, 准教授 (80374495)
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Co-Investigator(Renkei-kenkyūsha) |
ONODERA Shunsuke 北海道大学, 医学(系)研究科, 特任助教 (30374458)
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Project Period (FY) |
2009-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 放射線治療 / 認知機能 / 脳腫瘍 / 拡散テンソル画像 / 神経イメージング / 転移性脳腫瘍 / 全脳照射 / 定位放射線照射 |
Research Abstract |
Adverse radiation effect after brain radiation may cause severe deterioration of neurocognitive function (NCF). The lack of standardized objective scale to determine the severity of the decline of NCF has been an obstacle to investigate the way to prevent and/or treat this condition. We assorted Japanese version of neurocognitive battery which is compatible to those used in Western countries. In a prospective study, this NCB demonstrated deterioration of NCF 4 months after whole-brain radiation therapy (WBRT), recovery at 8 months, and decline at 12 months. In the examination of diffusion tensor imaging, mean diffusivity (MD), which could be a potential index to determine the damage to white matter, continued to increase overtime. At 8 months after radiation, the magnitude of %difference of MD compared with baseline was greatest at corpus callosum followed by cingulate. The correlation of findings in DTI and NCB is a matter of further investigation.
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Report
(6 results)
Research Products
(80 results)
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[Journal Article] Response Assessment in Neuro-Oncology (RANO) group. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group2013
Author(s)
Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge DR, Chang SM, Dancey J, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Lamborn KR, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Wen PY
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Journal Title
Lancet Oncol
Volume: 14
Issue: 10
Pages: e396-e406
DOI
Related Report
Peer Reviewed
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[Journal Article] Response Assessment in Neuro-Oncology (RANO) group. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group2013
Author(s)
Lin NU, Wefel JS, Lee EQ, Schiff D, van den Bent MJ, Soffietti R, Suh JH, Vogelbaum MA, Mehta MP, Dancey J, Linskey ME, Camidge DR, Aoyama H, Brown PD, Chang SM, Kalkanis SN, Barani IJ, Baumert BG, Gaspar LE, Hodi FS, Macdonald DR, Wen PY
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Journal Title
Lancet Oncol
Volume: 14
Issue: 10
Pages: e407-e416
DOI
Related Report
Peer Reviewed
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[Presentation] A New Choice of Treatments for Invasive Superficial Esophageal Squamous Cell Carcinoma: Investigation of Efficacy of Prophylactic Chemoradiation Therapy After Endoscopic Submucosal Dissection2013
Author(s)
Kawaguchi G, Obinata M, Sasamoto R, Takeuchi M, Ohta A, Tanaka K, Sato H, Ayukawa F, Abe E, Kaidu M, Kobayashi M, Aoyagi Y, Aoyama H
Organizer
ASTRO 55th Annual Meeting
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] DVH-based Comparison Analyses of PTV-coverage and Doses to Organs at Risk (OARs) between Localized Cancers of Large and Regular Volume Prostate Treated with High Dose Rate Brachytherapy (HDR-BT)2013
Author(s)
Kaidu M, Ayukawa F, Tanaka K, Obinata M, Sato H, Yamana N, Kawaguchi G, Oota A, Abe E, Sasamoto R, Aoyama H
Organizer
99th RSNA
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Brain metastasis-What is the optimal radiotherapy?2011
Author(s)
Hidefumi Aoyama
Organizer
The 24^<th> International Symposium Foundation for Promotion of Cancer Research. Malignant Brain Tumors : The Present Status and Future Prospects
Place of Presentation
Tokyo, Japan,国立がん研究センター国際研究交流会館(招待講演)
Year and Date
2011-11-24
Related Report
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[Presentation] An Internationally Compatible2010
Author(s)
Onodera S, Aoyama H, et al
Organizer
Japanese Neurocognitive Function Test Battery for the Assessment of Radiation-induced Brain injury
Place of Presentation
San Diego, USA
Related Report
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